exam 2 lecture 15 Flashcards
macrophage release of chemokines induced
neutrophil migration
innate immunity
recruitment of activated immune cells to sites of infection
cytokines involved in proinflammation
IL-1B, TNFalpha, IL-6, CXCL8(chemokine) and IL-2
rolling adhesion
glycoproteins that exhibit weak reversible binding to sialyl-Lewis X
T/F neutrophils are the first wave of cells recruited to the site of infection
true
tight binding
ICAM-1 is induced by TNFalpha to a LFA-1 integrin on neutrophils
diapdedisis
the neutrophil can now cross the endothelium
how does CXCL8 direct neutrophils to cross the endothelium and subsequent migration
concentration gradient
what recruits monocytes in the bloodstream
CCL2
CXCL8 is called a chemokine because
it promotes movement of various immune cells in a certain direction
what do lymphocytes and monocytes release when infection is detected
TNFalpha, IL-1, IL-6 and interferon gamma
what are the TNFalpha receptors
cysteine rich domains, TNFR1 and TNFR2
both the TNFR1 and TNFR2 pathways lead to what
apoptosis and inflammation and survival
what chain do IL-2, IL-4, IL-7, IL-9, IL-15, IL-21 have in common
gamma chain
what chain do GM-CSF, IL-3 and IL-5 have in common
beta chain