exam 2 lecture 12 Flashcards
T/F CPCRs are the most targeted human protein family for drug development
True
GPCR signal termination is cause by
phosphorylation by G protein-coupled receptor kinases GRKs
binding of beta arrestin in GPCRs causes what
desensitization
recruitment to Clathrin coated pits in GPCR termination causes what
internalization
G protein inactivation uses what to covert active form to inactive form
intrinsic GTPase activity
G protein inactivation is facilitated by
regulators of G protein signaling proteins RGSs
alpha i leads to
ion channels, inhibition cAMP, phospholipase, phosphodiesterases
alpha s leads to
increases cAMP
alpha q leads to
phospholipase C
alpha 12 leads to
Rho GEFs activation
G alpha has how many subtypes
20
what is Gs
dopamine D1 beta adrenergic receptors
what is Gi
dopamine D2 alpha adrenergic receptors
what does Gas do in cAMP mediated signaling
stimulates adenylate cyclase in response to a variety of hormones or neurotransmitters
what does adenylate cyclase do in cAMP mediated signaling
catalyzes conversion of ATP to cAMP