Exam 2 Genomics

Question 1

Metabolism of 6-MP pathway?

Answer 1

• 6-MP –> TPMT –> 6 methyl mercaptopurine

Question 2

Poor Metabolizer: Active & Pro drug?

Answer 2

• Pro drug: less drug gets converted into active drug
• Active: drug stays in system longer

Question 3

Rapid Metabolizer (CYP2D6*14) Pro drug & active drug?

Answer 3

• Pro drug: rapid onset/conversion of drug. Over time decreased effect
• Active: drug gets broken down faster. May need higher dose

Question 4

Purine Analogs
- Usage?
- How they work?
- side effect of high doses?

Answer 4

• Used for rapid growing cells such as in leukemia, IBS, etc
• Interfere with nucleic acid synthesis
• Too high doses could suppress immune system completely

Question 5

Warfarin
- 2 enzymes checked to check metabolism?
- Which enzymes slow down metabolism?

Answer 5

• CYP2C9 & VKORC1 used to test for Warfarin metabolism
• CYP2C92 & CYP2C93 slow down metabolism

Question 6

How does Herceptin work?

Answer 6

• Herceptin binds to growth factor receptor & blocks growth factor binding

Question 7

Herceptin is expensive when is it given?

Answer 7

if HER-2 + & ER & PR negative

Question 8

Delineate the pathway of Tylenol in the gut before and after biotransformation.

Answer 8

• Into intestine –> absorbed –> liver metabolized via glucuronidation –> bile –> ABCC pumps it back into intestine –> feces