EXAM #2: CV PHARM VII

Question 1

What is Baroreflex activation therapy used to treat?

Answer 1

Resistive HTN

Question 2

How does Baroreflex activation therapy work?

Answer 2

Increased baroreceptor firing=

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Question 3

List the drugs that are safe for use in pregnancy for HTN.

Answer 3

Methyldopa 
Labetalol 
Nifedipine 
Hydralzine
Metoprolol

Question 4

What is the disadvantage of methyldopa as an anti-HTN in pregnancy?

Answer 4

Short duration of action requires dosing BID or TID

Question 5

Why is Labetalol preferred over other B-blockers for anti-HTN in pregnancy?

Answer 5

Alpha-blockade on uteroplacental blood flow

Question 6

What is the advantage of Nifedipine as an anti-HTN in pregnancy?

Answer 6

A slow release preparation exists

Question 7

What is the advantage of Hydralazine as an anti-HTN in pregnancy?

Answer 7

Extensive clinical application

Question 8

What is the disadvantage of Hydralazine as an anti-HTN in pregnancy?

Answer 8

Risk of maternal hypotension

Question 9

What drugs are generally avoided as anti-HTN in pregnancy?

Answer 9

Diuretics
Atenolol
Nitroprusside

Question 10

What drug classes are contraindicated as anti-HTN in pregnancy?

Answer 10

ACE inhibitors
ARB

Both are shown to cause multiple fetal abnormalities