Exam 2 - Ch. 21 Flashcards
Premature rupture of membranes (PROM)
Rupture of membranes prior to the start of contractions at or after 37 weeks
Risks associated with PROM
↑ risk of prolapsed cord, placental abruption, chorioamnionitis, cord compression, & neonatal ICU admissions
~ 90% of women with PROM go into labor within what time frame
Within 24 hours
Preterm premature rupture of membranes (PPROM)
Rupture of membranes prior to 37 weeks of gestation (≤36.6 weeks GA)
Risks of PPROM
↑ risk of infection (chorioamnionitis, endometritis, septicemia),
placental abruption
fetal malpresentation
cord prolapse, and precipitous labor
Risks that predispose a pregnant woman to PPROM
Most women with PPROM do not have identifiable risk factors, however, the incidence is higher in women who smoke, had a previous PPROM, and any vaginal bleeding during pregnancy.
PROM/PPROM Assessment
Sterile speculum exam
Nitrazine pH test
Arborization test (ferning)
Presence/absence of meconium-stained fluid
What percentage of women will go into labor w/in 24 hrs of PROM
90%
What percentage of women will go into labor within 24 hours of PPROM?
50%
**Active management of PPROM/PROM
Induction of labor w/in 24 hrs of ROM associated w/ ↓ chorioamnionitis and NICU admissions
**Expectant management of PPROM/PROM
Delay of induction >24 hrs of ROM (spontaneous labor w/in 72 hrs 95% of the time)
Considerations with PPROM or PROM
GBS + women treated with antibiotics
PPROM treatment
Corticosteroids in pregnancies under 34 weeks to promote fetal lung maturity
Prevent intraventricular hemorrhage
Necrotizing Enterocolitis and ↓ neonatal death by 30-60%.
Antibiotic therapy because PPROM may have been caused by infection OR result in infection (usually azithromycin, ampicillin, or amoxicillin)
Tocolytics used to prevent, suspend, or slow labor (off-label)
May be used for 48 hours to allow time for a full course of corticosteroids to be administered to the mother.
Use of tocolytics for PPROM is controversial
Magnesium sulfate between 24-34 weeks for fetal neuroprotection
(↓ cerebral palsy in neonate)
Bed rest – not found to improve outcomes, done anyway in many cases
Delivery – most women w/ PPROM will deliver w/in a week depending on risk/benefit assessment
Meds for PPROM
Antibiotic therapy because PPROM may have been caused by infection OR result in infection (usually azithromycin, ampicillin, or amoxicillin)
Tocolytics used to prevent, suspend, or slow labor (off-label). May be used for 48 hours to allow time for a full course of corticosteroids to be administered to the mother. Use of tocolytics for PPROM is controversial
Magnesium sulfate between 24-34 weeks for fetal neuroprotection
(↓ cerebral palsy in neonate)
Why are tocolytics used in PPROM?
Tocolytics used to prevent, suspend, or slow labor (off-label). May be used for 48 hours to allow time for a full course of corticosteroids to be administered to the mother. Use of tocolytics for PPROM is controversial
Preterm labor
Labor that causes cervical change at less than 37 weeks GA; may be spontaneous or induced
Is preterm labor spontaneous or induced?
Both
What is the leading cause of death for children under the age of 5?
Preterm birth
**Common reasons for preterm induction of labor
Placental problems
History of uterine scarring
Fetal growth restriction
Hypertension
Preclampsia
Poorly controlled gestational diabetes
Pregestational diabetes poorly controlled
PPROM
Preterm labor (PRL) four main causes
- HPA Axis (hypothalamic-pituitary-adrenal axis) - maternal stress)
- Inflammation – systemic, GU tract, chorioamnionitis
- Bleeding – hormonal cascade caused by the bleed, associated with inflammation
Uterine Overdistention – - Polyhydramnios, multiple gestation
PTL Symptoms
Irregular contractions, often mild
Report of “menstrual-like” cramping
Low back pain
Sensation of vaginal or pelvic pressure
Light bleeding, spotting, or bloody show
Diagnosis of PTL
Cervical dilation of 3 cm or more
Cervical shortening on ultrasound
Positive fetal fibronectin test (fFN): Evaluation of a protein concentrated between the placenta and the decidua of the uterus
Elevated levels associated with birth within 10 days (+ fFN: >50mg/mL)
Negative result is reassuring
Positive fetal fibronectin test (fFN)
Protein concentrated between the placenta and the decidua of the uterus
Elevated levels associated with birth within 10 days (+ fFN: >50mg/mL)
Negative result is reassuring
PTL interventions
- Suppression of Labor - Tocolytics – indomethacin, nifedipine, terbutaline, magnesium sulfate
Generally not used before 24 or after 34 weeks - Physical Activity Restriction - Common recommendation, lacks evidence base
- Sexual activity can stimulate contractions
- Progesterone Supplementation-Shortened cervix (PRE-labor) - progesterone to extend pregnancy, Not indicated when +fFN test result
- Medication Management - Corticosteroids from ~23 to 34 weeks, Antibiotics, Magnesium sulfate for fetal indications (as well as tocolytic indication)
What is chrioamnionitis
Infection of the amnion, chorion, or both
Common cause of chrioamnionitis
Commonly caused by the ascent of bacteria through the cervix
Risk factors for chorioamnionitis
PPROM, PROM, multiple digital vaginal exams, prolonged labor, preterm birth, HIV, invasive fetal/ctx monitoring, genital tract infx
Maternal Complications of chrioamnionitis:
Maternal: prolonged labor, postpartum hemorrhage, wound infection, endometritis, venous thrombus, sepsis
Neonatal Complications of chrioamnionitis:
Neonatal: sepsis/septic shock, perinatal death, asphyxia, CP, pneumonia, meningitis, IVH, neurodevelopmental delay, prematurity-related problems
Diagnostic criteria for chrioamnionitis
maternal fever greater than 38˚C (100.4° F) plus at least two of the following:
fetal tachycardia
maternal tachycardia
uterine tenderness
foul-smelling discharge
elevated white blood cell count (over 15,000 cells/mm3)
Treatment for chorioamnionitis
broad spectrum antibiotics – usually ampicillin and gentamicin