Exam 2 Flashcards
Palliative Care, altered presentation
Palliative Care
Care for patients with serious, life limiting illness
“To cloak”
To make less severe or intense, to relieve or sooth the symptoms of a disease or disorder
Frailty
State of increased vulnerability to poor resolution of homeostasis after a stressor event which increases risk of adverse outcomes.
Gradual decreases in physiological reserve occurs with aging, but in frailty decrease is accelerated & homeostatic mechanisms start to fail.
3 common things seen with frailty
Falls
Delirium
Fluctuating disability
Altered presentation risk factors
at greatest risk for atypical presentation
- Over age 85
- Multiple co-morbidities
- Multiple medications
- Cognitive or functional impairment
INDICATORS of frailty
Presence of 3 or more:
- Self-reported exhaustion
- Unintentional weight loss >10lbs/yr
- Muscle weakness
- Walking slowly
- Low physical activity
Geriatric Syndromes
MOST COMMON:
- Falls
- Dehydration
- Pain
- Decrease in appetite
- Dizziness
- Loss of functional ability
- Incontinences
Other
- Adverse drug reactions
- Skin breakdown
- Sleep disorders
Pharmacokinetics
How BODY acts on DRUG
how drugs move thru body & how quickly this occurs. Gradual progressive decline in organ function affects pharmacokinetics
Pharmacokinetics - Elements
- Absorption
- Distribution
- Metabolism
- Excretion
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Absorption
Movement of drug from site of administration into general circulation
Rate of absorption may be slowed due to:
- Delayed gastric emptying
- Reduced blood flow
- Substances such as food & inert drug ingredients
Distribution
-Movement from plasma into cells
Four factor that alter distribution
- Increased % body fat
- Decreased lean body mass
- Decreased total body water
- Reduced concentration serum albumin
Metabolism
Hepatic metabolism declines due to:
- reduced blood flow to liver
- decreased liver mass, decreased enzyme activity
How many half-lives to eliminate a given drug
5 half-lives