Exam 2

Question 1

MOA Anti-Arrhythmias CLAS ONE

Answer 1

Na+ Channel Blockers

Question 2

Class 1A Anti-Arrhythmias

Answer 2

Quinidine
Procainamide
Disopyramide

Question 3

Class 1B Anti-Arrhythmias

Answer 3

Lidocaine
Mexilietine
Tocainide

Question 4

Class 1C Anti-Arrhythmias

Answer 4

Flecainide
Propafenone
Moricizine(Ethmozine)

Question 5

What phase of action potential do Class one Anti-Arrhythmia’s effect?

Answer 5

Phase 0

Question 6

Class 1 Anti-arrhythmic Acronym

Answer 6

Double Quarter Pounder
Lettuce Mayo Pickle
Fries Please

Question 7

Contraindication for the entire class one

Answer 7

• 2nd/3rd degree block unless pt has functional pacemaker

- Increased QT

Question 8

What is preload?

Answer 8

End diastolic volume (EDV) at the BEGINNING of Systole

Question 9

What is afterload?

Answer 9

Ventricular pressure at the END OF SYSTOLE

Question 10

What determines the End-Systolic-Volume?

Answer 10

The Afterload

Question 11

Glyceryl Trinitrate

Answer 11

Nitroglycerin

Question 12

Glyceryl Trinitrate is metabolized by what if it is administered orally?

Answer 12

Glutathione-S-transferase

to produce active NO

Question 13

Isosorbide is metabolized to what two metabolites?

Answer 13

Isosorbide-2-mononitrate

Isosorbide-5-mononitrate

Question 14

Which isosorbide metabolite has the longest half life?

Answer 14

Isosorbide-5-mononitrate

Question 15

What are the 3 ways that ON’s cause their effect?

Answer 15

1-Dilation on venous capacitance vessels(decrease Preload)
2-Mildly dilate arteriolar resistance vessels(decrease afterload)
–These 2 decrease myocardial oxygen demand
3-Dilate large epicardial arteries (Increase Myocardial O2supply)

Question 16

IN SHORT-ON’s do what?

Answer 16

Decrease Demand, Increase Supply

Question 17

ON’s exert the majority of their effect by doing what…

Answer 17

Dilating the Venous Capacitance Vessels

Question 18

MOA of CCBs

Answer 18

Inhibit voltage gated L-type Ca2+ channels that lead to a decrease in Ca2+ influx causing relaxation of the vascular smooth muscle.

Question 19

Amlodipine

Answer 19

Norvasc

Question 20

Nifedipine

Answer 20

Procardia

Question 21

Nicardipine

Answer 21

Cadene

Question 22

Diltiazem

Answer 22

Cardizem

Question 23

Verapamil

Answer 23

Isopten

Question 24

CCBs that act on the HR

Answer 24

Diltiazem, Verapamil

Question 25

Which CCBs cause a decrease in Myocardial O2 DEMAND

Answer 25

Diltiazem, Verapamil

Question 26

How do CCBs increase the Myocardial O2 Supply?

Answer 26

By decreasing the peripheral resistance which increases Coronary blood flow, which increases myocardial O2 supply

Question 27

CCBs that increase the myocardial O2 SUPPLY

Answer 27

Amlodipine, Nifedipine, Nicardipine

Question 28

Do CCBs reduce Preload or Afterload?

Answer 28

REDUCE AFTERLOAD

Question 29

How do Beta Blockers help reduce Myocardial O2 demand?

Answer 29

They decrease HR and contractility, and enhance diastolic relaxation

Question 30

Beta Blockers that are used for treating MIschemia?

Answer 30

Timolol, Propranolol, Metoprolol

Question 31

Why are Timolol, Propranolol, and Metoprolol the only BB used for MIschemia?

Answer 31

Because they do no have the intrinsic sympathomimetic activity

Question 32

Timolol

Answer 32

Blocadren

Question 33

Timolol is usually used for

Answer 33

Intraoccular eye pressure---Glaucoma

Question 34

Propranolol

Answer 34

Inderal

Question 35

Metoprolol

Answer 35

Lopressor