Exam 2 Flashcards
Mood Disorders
- Depressive Disorders
- ______ _________ disorder.
- _________ _________ disorder.
- Bipolar and related disorders
- ________ disorder __.
- ________ disorder __.
- ___________ disorder.
Major depressive disorder
Persistent depressive disorder.
Biopolar disorder I
Bipolar disorder II
Cyclothymic disorder
Types of moods:
*_________: extreme sadness and gloominess.
*_____/__________: intense/unrealistic feelings of excitement and euphoria.
*_____-moods: symptoms of both mania AND depression.
Depression
Mania/hypomania
Mixed
Major Depressive Episode
- Criterion A: __ of the following criteria, lasting for at least a __ week period, change from ________ functioning.
- Depressed mood
- Anhedonia (i.e, loss of interest or pleasure)
- Appetite/weight disturbance
- Sleep disturbance
- Psychomotor agitation or retardation
- Fatigue/loss of energy
- Worthlessness or excessive/inappropriate guilt
- Difficulty concentrating/indecisiveness
- Suicidal ideation
- The episode must cause clinically significant distress/impairment.
- Episode not attributable to the effects of a ________ or other medical condition.
5
2
previous
substance
Manic Episode
*Criterion A: distinct period with abnormally elevated or irritable mood and goal-directed activity lasting ≥ __ week.
- Criterion B: __ or more of:
- Inflated self-esteem/grandiosity
- Decreased need for sleep
- Talkativeness, pressured speed
- Flight of ideas, racing thoughts
- Distractibility
- Increased goal directed activity or psychomotor agitation
- Excessive involvement in pleasurable and risky behaviors
- Clinically significant distress, impairment, hospitalization, or psychotic features.
- Not due to the physiological effects of a substance or another medical condition.
1
3
True or false:
-You can have an episode without having the disorder.
True
Hypomanic Episode
- Same as manic episode except:
- At least __ days.
- Noticeable by others, but not severe enough to cause marked impairment in functioning.
4
Mixed Episodes
*Meets criteria for BOTH _____ episode and ______ ___________ episode (except in ________).
manic episode ( at least 3 criteria) + major depressive episode (at least 5 criteria)
duration
Postpartum vs. Baby Blues
*Is giving birth a risk factor for Major Depression?
- Pospartum “Blues”
- [positive/negative] stressor
- Emotional lability, crying easily, irritability, intermixed with happy feelings.
-50-70% often experience these symptoms within 10 days after giving birth.
No, most studies do not uphold this common belief.
positive
- ________ ________ disorder
- Characterized by persistent down or depressed mood (i.e., sadness and/or loss of interest in pleasurable activities) occurring more days than not.
Major depressive disorder
Major Depressive Disorder
- Criterion A: __ of the following criteria, lasting for at least a __ week duration, change from previous functioning.
- DEPRESSED MOOD*
- ANHEDONIA* (i.e, loss of interest or pleasure)
- Appetite/weight disturbance
- Sleep disturbance
- Psychomotor agitation or retardation
- Fatigue/loss of energy
- Worthlessness or excessive/inappropriate guilt
- Difficulty concentrating/indecisiveness
- Suicidal ideation
*MUST have at least __ of the first two criteria + __ more criteria to have MDD. If not, then it’s just an _________.
5
2
1, +4 more
episode
Major Depressive Disorder
- Criterion A: presence of a ______ __________ _______.
- Single (initial) episode
- Recurrent episode
- Criterion B: clinically significant distress/impairment.
- Criterion C: episode not attributable to the effects of a substance or other medical condition.
- Criterion D: MDE not better accounted for by another disorder.
***Criterion E: NO HISTORY OF _____ or __________ EPISODES.
major depressive episode (MDE)
manic or hypomanic episodes
When diagnosing someone for MDD, if they have _______ or __________, they are not longer eligible for MDD.
mania or hypomania
Major Depressive Disorder
- Depressive episodes are often time-limited
- __ -__ months on average
- Greater than 2 years –> chronic MDD (10-20% of diagnoses)
- Remission of Symptoms
- Greater than 2 months w/o clinically significant symptoms
- Inter-episode recovery (i.e, experiencing NO symptoms?)
- Recurrence
- 25-40% within 2 years
- 60% within 5 years
- 75% within 10 years
- 87% within 15 years
6-9
Major Depressive Disorder
- Prevalence
- 20.9% lifetime, 8.6% 1-year
- Gender
- 1 in __ females vs 1 in __ males (adults)
- 1:1 male to female during childhood
- 1:__ male to female by adulthood
- Age of onset
- Late adolescences-early adulthood
- Later onset (≥60 years old) - difficult to determine due to other health related illnesses (e.g., dementia).
- Comorbidity
- _______ disorders, _________ use disorders, eating disoders, personality disorders
–So if you meet criteria for MDD, there’s a high chance that you’ll likely meet criteria for another disorder as well ( around 56% chance)
1 in 4 females vs 1 in 10 males (adults)
1:2 male to female by adulthood
Anxiety, substance
_________ _______ Disorder:
-Characterized by persistent down or depressed mood occurring more than not for greater than 2 years.
Persistent Depressive
Persistent Depressive Disorder
*Criterion A: ________ mood, more days than not, for __ years.
- Criterion B: __ or more:
- Poor appetite or overeating
- Sleep disturbance
- Low energy or fatigue
- Low self-esteem
- Poor concentration/indecisiveness
- Feelings of hopelessness
- Criterion C: never w/o symptoms for more than __ months at a time.
- Criterion D: symptoms of MDD may be continuously present for 2 years.
- Criterion E: NO HISTORY of _____/________ episode.
depressed, 2 years
2 or more
2
manic/hypomanic
Persistent Depressive Disorder
- Prevalence
- 18.0% lifetime
- Age of Onset
- Adolescences-early adulthood
- > 50% presenting for treatment have an onset before age 21
- Course
- Average duration is __-__ years, but can persist for 20+ years
- Chronic stress increases severity of symptoms
- 10 year period – 74 percent recover, but 71% of those relapse
- Double depression
4-5
Double depression = _________ ________ disorder + ______ _________episode.
Persistent depressive disorder + major depressive episode
MDD: Causal Factors
*Biopsychosocial Model
- Biological factors
- Genetic influences
- Neurochemical
- Hormonal
Yuh
MDD: Biological Factors
*Genetic Factors
- Family Studies
- -Individuals who are first degree relatives of individuals w/ depression have a __-__x increased risk of developing MDD themselves
- -These individuals tend to develop ______ first.
- -Earlier onset
-Twin studies
–__________ twins 2x as like to develop MDD as
________ twins twins
–But, most variance accounted for by
non-shared environment
-Adoption studies
–More depression in biological relatives
of depressed adoptees
3-5
anxiety
Monozygotic (identical), dizygotic
VERY IMPORTANT
*As a biological vulnerability, having two [long/short] _________-________ genes [increases/decreases] your risk of developing depression, if you’ve experienced _________ life events.
two short serotonin-transporter genes
increases
stressful
MDD: Biological Factors
- Neurochemical Factors
- _________ Hypothesis
- -Low _________ as biological risk factor
- -Levels of __________ and ________ determine direction of mood disorder.
**Low serotonin + low norepinephrine and low dopamine
= depression
- Hormonal Factors
- -Cortisol – signal for response to medication?
Permissive
serotonin
norepinephrine and dopamine
Low _______ + low __________ and low ________
= depression
serotonin, norepinephrine, dopamine
People with depression tend to have [higher/lower] levels of cortisol.
higher
MDD: Causal Factors
- Psychological/environmental factors
- Stressful life events
- Cognitive theories
- Interpersonal factors
Yuh
MDD: Psychological factors
- Stressful life events
- -Stronger association with initial depressive episode
- -Long-term stress –> abnormal nucleus accumbens functioning.
Explanation:
- Stressful live events are associated with that first onset of depression, they’re less associated with recurrent episodes.
- Long term stress is associated with increased _______, and what we see is that over time, the stress makes the nucleus accumbens _________.
- The nucleus accumbens is associated with producing _________ in response to pleasure, and what we see in stress and cortisol levels overtime, is that it makes the nucleus accumbens not respond in terms of pleasurable events, and in fact, it can make things worse, and we see this non-response to acute stress.
cortisol
malfunction
dopamine
MDD: Cogntive Theories
*_____’s Cogntive Model - Negative Cognitive Triad
- You have negative views about the _____, the ______, and _______.
- This series of thoughts feed into each other, and feed into depression.
- You can imagine that having negative views about the self (I’m worthless) + negative views about the world (everyone hates me b/c I’m worthless) + negative views about the future (I’ll never be good at anything b/c everyone hates me) would lead to feeling pretty bad.
- Depression is maintained by these thoughts.
- All or non thinking, selective abstraction
- Leads to depressive schemas
Beck’s
world, future, yourself
People w/ depression perceive the world more __________.
accurately.
MDD: Cognitive Theories
- ________:
- The process by which individuals explain the causes of behavior and events in a negative manner.
- ________ _________:
- Sense of powerlessness
- The idea that people don’t have any power or control to change what’s going on around them, and that they’re making all these negative attributions.
- They can’t do anything about all these negative events around them and it’s their fault to the extent that they cannot change.
- ___________ theory:
- Pessimistic attributional style
- We go from this learned helplessness component, to when you add in this “why?” component, we get hopelessness.
- Simply feeling hopeless enough can lead people to depression.
Attribution
Learned helplessness
Hopelessness theory
MDD: Interpersonal Factors
- Interpersonal Factors
- Lack of ______ ______
- Poor social skills
- Relationship distress
- -Excessive-__________ seeking (trying to solicit that you are worthy).
- -________ feedback seeking (I’m so dumb, that was stupid of me…saying these things to get people to say positive things about them).
- These factors both _______ onset of depression and are _________ by depression.
- Related to high rates of relapse/recurrence
social support
reassurance
Negative
precede, worsened
MDD: Evolutionary Approach
- Resource conservation:
- Perceived loss leads to in-the-moment _________ and energy _________ for later
- Stay stuck in same situation without reward
- _______ __________ hypothesis:
- De-escalating approach (withdraw, give up power)
- Social dominance…there is always a loser, and that person always has to withdraw. The way to maintain this social hierarchy, sometimes you have to submit to being the loser, and these depressive symptoms/behaviors can be a de-escalation or signal of submission.
- ______ risk hypothesis
- Interpersonal disruption
- Protects against future losses by withdrawing
- Attachment:
- Experience of loss
protection, conservation (Dr. R doesn’t buy this theory too much)
Social competition
Social
Depressive Disorders: Biologically-Based Treatments
*Medications
- __________ Oxidase ________ (MAOIs)
- -Inhibits the enzyme responsible for breakdown of _________ and __________
- -Used for atypical depression
- _______ Antidepressants
- -Increases monamines (norepinephrine)
- -50% do not respond
- Selective Serotonin Reuptake Inhibitor (SSRIs)
- -Prozac, Zoloft, Paxil
- -Takes up to 6 weeks to work
-Newer generation drugs – Effexor (SNRI) and Wellbutrin (NDRI)
Monoamine Oxidase Inhibitors
serotonin, norepinephrine
Tricyclic
What is the primary medication for depression?
Selective Serotonin Reuptake Inhibitors (SSRIs)
Depressive Disorders: Biologically-Based Treatments
- ___________ Therapy (ECT)
- Severe depression, non-responders
*Transcranial Magnetic Stimulation
-Pulsating magnetic fields stimulate certain regions in the
cortex (5 days/week 2-6 weeks)
-Recent review supports effectiveness
- Light therapy
- Originally used for seasonal affective disorder
Electroconvulsive
Depressive Disorders: Psychotherapy Treatments
- _________ _________ (BA)
- Refers to increasing activities and interactions - behavioral scheduling
- Getting people to do the things they’re used to doing again.
- Very effective, maybe as effective as CBT
*_________-________ therapy (CBT)
-10-12 sessions
-Focus on ____ and ____, what’s maintaining the disorder right now?
-Identify dysfunctional thoughts and challenge them
-Engage in behavioral activation
-As effective as medications, and BETTER at preventing
relapses and recurrences.
Behavioral Activation
Cognitive-behavioral
here and now
If you use medication and CBT simultaneously, vs medication vs CBT, anything with CBT has better outcomes. Why?
- People don’t have the same coping skills who went through CBT
- Learned skills on how to identify thoughts and behavior
Depressive Disorders: Psychotherapy Treatments
- __________ Therapy (IPT)
- Identify and change maladaptive interaction patterns with others
- As effective as medications and CBT, but still early in the research
- Comes out of the psychodynamic model.
- -Idea behind this is that as depression is maintained by these problematic interpersonal relationships, IPT is focusing on helping you figure out how to have better, stronger, more fulfilling interpersonal relationships and getting rid of those ‘excessive-reassurance seeking’ and ‘negative feedback seeking’ issues.
Interpersonal
Manic Episode - Review
*Criterion A: distinct period with abnormally elevated or _______ mood and goal‐directed activity lasting≥ __ week
- Criterion B: __ or more of:
- Inflated self‐esteem/grandiosity
- Decreased need for sleep
- Talkativeness, pressured speech
- Flight of ideas, racing thoughts
- Distractibility
- Increased goal directed activity or psychomotor agitation
- Excessive involvement in pleasurable and risky behaviors
- Clinically significant distress, impairment, hospitalization, or psychotic features
- Not due to the physiological effects of a substance or another medical condition
irritable
1
3
Hypomania and Mixed Episode - Review
- Hypomanic Episode
- Same as Manic except:
- At least __ days
- -Noticeable by others, but not severe enough to cause marked impairment in functioning
- Mixed Episodes
- Meets criteria for both _____ Episode and _____ ________ Episode (except duration).
4
Manic
Major Depressive
________ Disorders
-Characterized by a cycling of manic (hypomanic) and depressive episodes.
Bipolar
Bipolar I Disorder:
- Criterion A: At least one ______ episode
- Criterion B: Manic and major depressive episode(s) not better accounted for by another disorder.
- Remember:
- History of major depressive episode(s) [not required]
- Symptoms must represent a major change from an individual’s normal mood or behavior.
manic (chances are, if you’ve had a manic episode, it is likely you will have a depressive episode –> you will cycle from up (mania) to down (depression))
Bipolar II Disorder:
- Criterion A: Presence or history of ≥ 1 __________ episode AND ≥ 1 _____ _________ episode
- Criterion B: Never experienced a _____ or _____ episode
- Remember:
- Hypomanic + depressive episodes
- Symptoms must represent a major change from an individual’s normal mood or behavior
hypomanic, major depressive (think, Bipolar II need II things)
manic, mixed
If you have ever had a manic episode, you CANNOT get a ________ __ diagnosis.
If you’ve had a manic episode = bipolar __.
bipolar II (this is b/c manic trumps hypomanic)
I
Cyclothymic Disorder
*Criterion A: numerous periods of sub‐clinical __________ symptoms and __________ symptoms for __ years
*Criterion B: No symptom‐free periods of __ months, and
symptoms present more than half the time during 2 years
*Criterion C: No ________, _____, or _________ episodes
- Not better accounted for by another disorder
- Not the result of a substance or other medical condition
- Clinically significant distress, impairment
**Hint: Think of it as the Bipolar equivalent to Persistent
Depressive Disorder
hypomanic, depression, 2 years
2
depressive, manic, hypomanic
Cyclothymic Disorder
*Criterion A: numerous periods of sub‐clinical __________ symptoms and __________ symptoms for __ years
*Criterion B: No symptom‐free periods of __ months, and
symptoms present more than half the time during 2 years
*Criterion C: No ________, _____, or _________ episodes
- Not better accounted for by another disorder
- Not the result of a substance or other medical condition
- Clinically significant distress, impairment
**Hint: Think of it as the Bipolar equivalent to Persistent
Depressive Disorder
hypomanic, depression, 2 years
2
depressive, manic, hypomanic
MDD is also known as ________ depression.
unipolar
Unipolar mania = you’re meeting criteria for _____ but not quite meeting everything for _________.
mania, depression
Bipolar Disorder: Prevalence and Course
- Prevalence
- Bipolar I‐ ~1%
- Bipolar II‐ ~1.1%
- Cyclothymia ‐ ~2.4%
- Gender Ratio
- __:__ women to men
- Average age of onset
- Late adolescence‐early adulthood – average 22
- Course
- Episodic (swings in moods/typical functioning)
- Comorbidity
- Substance use disorders
1:1 (unlike depression)
Bipolar (mania + depressive) vs. Unipolar (just depressive)
- Manic Episodes
- Tend to be much [longer/shorter] than depressive episodes
- Depressive Episodes (within a Bipolar diagnosis)
- Tend to be [less/more] severe than unipolar depression and often have:
- -Greater mood lability
- -More psychotic features
- -More substance abuse
- -Greater psychomotor retardation
- Overall episodes shorter than MDD, but greater number of episodes during their lifetime.
- Rapid cycling – 3‐4 episodes within one year
*Prognosis? Bipolar disorder: MANAGEMENT of the symptoms.
shorter
more
Mood episodes within bipolar disorder going to be [more/less] severe and dysfunctional.
more
_______ disorder is one of the most heritable disorders.
Bipolar
Bipolar: Biological Factors
- Genetic Factors
- One of the most _______ disorders
- No single ____ responsible
- Neurochemical Factors
- _________ Hypothesis
- -LOW serotonin + HIGH norepinephrine and HIGH dopamine = bipolar disorder
- Hormonal factors
- Elevated _______ levels during depressive episodes
- Thyroid hormone can precipitate manic episodes
- Biological rhythms
- Disruptions in _____ patterns can trigger manic episodes
- Seasonal patterns also common
heritable
gene
Permissive
cortisol
sleep
What is the permissive hypothesis for bipolar disorder?
_____ serotonin + _____ norepinephrine and ______ dopamine = bipolar disorder
LOW, HIGH, HIGH
Bipolar: Psychological Factors
- Similar to unipolar disorders
- Stressful life events
- Personality
- Cognitive patterns
*Interpersonal processes very important
-Dysfunctional family interactions often linked to onset
of _____ episodes
–High expressed emotion
manic
Cultural Considerations
*Prevalence rates of unipolar depression _____ across
countries
- Less variability in rates of bipolar disorder
- Due to stronger genetic vs. environment component?
*Differences in symptom ________
-E.g., depression manifests as physical symptoms in
Asian cultures
differ
expression
Treatment Medications
- Mood stabilizers: to keep people from fluctuating too much
- _______ (incredibly effective, but very toxic)
- Anti_________ (e.g., Depakote)
- -Effective, but not as effective for suicidal ideation
- Antidepressants
- SSRIs
- However, antidepressants can trigger manic episode
Lithium
convulsants
Bipolar disorder does not ____. It’s more about how we manage and keep people _______ over time.
remit, stable
Treatment - Other
- Electro_________ Therapy (ECT)
- Has been show to help with _____ episodes
*Cognitive‐Behavior Therapy (CBT)
-Good for ________ symptoms, not as effective for
_____ symptoms
*Interpersonal and ______ Rhythm Therapy
-Taught how to recognize the effect of interpersonal
events on their social and circadian rhythms and to
regularize these rhythms
Electrconvulsive
manic
depressive, manic
Social
Suicide
*One of top __ leading causes of death
-__th leading cause of death overall
-3rd among 15‐19 y.o.
-However, rates vary considerable across different
countries
- Gender
- Attempts: [men/women] > [men/women] (3X)
- Completions: [men/women] > [men/women]
*Elevated rates in depressed individuals and other
mentally ill
-15% of those diagnosed with recurrent MDD
10
10th
women > men
men > women
Interpersonal Theory of Suicide
1) ________ to commit suicide
“Fearlessness and pain tolerance.”
2) Perceived ____________
“Others would be better off without me.”
3) Thwarted __________
“Idea of isolation, part of a group/not accepted
Capability
burdensomeness
belongingness