Exam 2-2 Flashcards
Effects of which Norepinephrine: FAM
F ight or flight
A ttention or Arousal
M ood
Effects of which Dopamine? (HEMD)
H hypothalamus hormones
E motions and thoughts
M uscle movement
D ecision making
Effects of Serotonin: MASHH
M ood A ggression S sleep and sex H unger H ormones
Effects of Histamine: IGA
I nflammatory response
G astric secretion
A lternest
Effects of GABA: MIAIAEA
M uscle-relaxant I nhibition A ggression reduced I mpair cognition and psychomotor function A nxiety E citation A nticonvulsant
Effects of Glutamate: LAME
L earning
A MPA
M emory
E xcitatory
Effects of Acetylcholine: LMMMPS
L earning M emory M ood M ania P arasympathetic S exual aggression
Part of the brain that plays role in emotional status and psychological function
Limbic system
Regulates the entire sleep/wake cycle
RAS- reticular activating system
Neurotransmitters associated with depression
**Deficiency of Serotonin and Norepinephrine
Dopamine decrease, acetylcholine increase)
Neurotransmitters associated with schizophrenia
**Increase of dopamine
Increase of norepinephrine, Decrease of GABA
Neurotransmitters associated with anxiety
**GABA decrease
Increase of norepinephrine and seratonin
Biochemical and physiological effects of drugs on the body
Pharmacodynamics
The action of the person on the drug
Pharmacokinetics
5 neurotransmitters associated with psychiatric illnesses:
Dopamine Serotonin Norepinephrine Glutamate GABA
Antianxiety drugs are associated with which neurotranmitter?
GABA-A
Diazepam (Valium) drug class
Benzodiazepine
Clonazepam (Klonopin) Drug class
Benzodiazepine
Benzodiazepines are known to be __________.
Sedative
Common side effects of benzodiazepines include:
Interference with motor ability, attention and judgement
Muscle relaxers
Falls and broken bones
Ataxia
Anticonvulsant
Should not be taken with other CNS depressants
Alprazolam (Xanax) drug class
Benzodiazepine without sedative response
Lorazepam (Ativan) drug class
Benzodiazepine without sedative response
flurazepam (Dalmane), temazepam (Restoril), triazolam (Halcion)0, estazolam (Prosom), and quazepam (Doral) are all….
Hypnotic benzodiazepines used for insomnia
Z-drugs are _________.
Hypnotics
Zolpidem (Ambien), zaleplon (Sonata), and eszopiclone (Lunesta) are all…
Z-drugs (hypnotics)
-Sedative effects without anti-anxiety, anticonvulsant, or muscle relaxing effects
Doxepin (Silenor) is used for… and should be avoided….
treatment of insomnia: difficulty maintaining sleep
Avoided with severe urinary retention or on MAOIs and CNS sedatives
Ramelteo (Rozerem) is what drug class? side effects?
Melatonin receptor agonists
*headaches, dizziness, increased prolactin
Buspirone (BuSpar) has what effect? side effects?
Reduces anxiety without sedation
Dizziness and insomnia
*can be used with other CNS depressants (including alcohol)
*No addiction
What neurotransmitters is the target for antidepressants?
Norepinephrine and Serotonin
Fluoxetine (Prozac), Sertraline (Zoloft), Paroxetine (Paxil), Citalopram (Celexa), escitalopram (Lexapro), Fluvoxaine (Luvox) are all…
SSRIs
Nortiptyline (Pamelor), Amitriptyline (Elavil), and Imipramine (Tofranil) are all…
TCAs
Side effects of TCAs
Sedation
Drowsiness
Fatal Overdose (cardiac)
AntiCholinergic effects
Side effects of SSRIs
Anorexia Apathy Low libido Nausea/vomiting ** Low anticholinergic effects for patients with narrow angle glaucoma
Venlafaxine (Effexor), Desvenlafaxine (Pristiq), and Duloxetine (Cymbalta) are all…
SNRIs
SNRIs side efefcts
Hypertension
** Used to treat GAD, diabetic peripheral neuropathy, fibromyalgia pain
Mirtazapine (Remeron) is a…
SNDI
Side effects of Remeron/ SNDI
Sedation Weight Gain POSITIVE: Antiemetic (for nauseated patients) Minimal sexual dysfunction and improved sleep
MAOIs target which neurotransmitters?
ALL Monoamines: Norepinephrine, epinephrine, dopamine, and serotonin
**Tyramine
Isocarboxazid (Marplan), Phenelzine (Nardil), Selegiline (EMSAM), and Tranylcypromine (Parnate) are all…
MAOIs
Bupropion (Wellbutrin, Zyban) is used for… side effects…. contraindications…
Smoking cessation
- side effects: insomnia, tremor, anorexia, weight loss
- Contraindicated in seizures, abrupt discontinuation of sedatives, and bulimia/anorexia
Vilazodone (Viibryd) and Trazodone (Oleptro) both can cause….
Insomnia
This drug has serious toxic effects including sinus bradycardia and convulsions
Lithium