Exam 2 Flashcards
Depressive disorders all share symptoms of
Sadness, loneliness, emptiness, irritability, somatic (body) concerns like back/neck pain, and impairment of thinking
All impact a person’s ability to function
Can get agitated or delusional
Disruptive mood dysregulation disorder
Children being diagnosed with bipolar, temper tantrums, violence, recognized this as a mood dysregulation. Predominantly seen in adolescents up to 18, less bipolar being diagnosed now
More of a childhood disorder
Persistent depressive disorder
Happens for years, symptoms are all the time
Can work, function, be social, have friends, but having a difficult time. Pure depression can’t do this
Dysthymic disorder
Premenstrual dysphoric disorder
More than physical changes like PMS
Uncomfortable in their own skin, feel better when menses starts (symptoms go)
Medication usually works for them
Substance-induced depressive disorder
Cocaine use makes you high, the opposite bottoms you out
Relaxants can make you depressed (alcohol)
Depressive disorders due to another medical condition
Open heart surgery makes you more likely to have depression (95%)
Parkinson’s, cancer, end-stage terminal illness like cardiac, respiratory, renal
Genetics and depression
37% incidence if a monozygotic twin is depressed, also genetic influences linked to earlier onset and recurrence
Biochemical etiology of depression
serotonin (affects mood, makes us feel good) and norepinephrine (behavior and attention, produced more when stressed, low in depression), dopamine, glutamate, acetylcholine
Hormones in depression
hypothalamic-pituitary-adrenocortical axis involvement
Inflammation in depression
c reactive protein and interleukin-6
Tests for depression (hormone)
Dexamethasone suppression test and high cortisol in urine tests for depression
Inflammation plays huge role in these illnesses, inflammatory biomarkers show this
Cognitive theory of depression
See a helpless situation, think helpless thoughts, world is hopeless, can’t get out of this circle (triad)
Changing negative thought and working it through to realize it’s not so bad (cognitive behavioral theory)
Learned helplessness
Happens when someone feels powerless over a situation, they learn to continue to function that way. If they’re stuck in traffic they don’t get over it
Patient health questionnaire
2 first questions ask about little interest in things. If yes, do you feel depressed and hopeless. If yes, automatically answer other 7 questions which are more serious like appetite or thoughts of hurting self, may be on constant observation. Med surg or other units ask the two questions. Psych unit uses Columbia screening tool
Assessment of depression
Questionnaire
Anergia
Anxiety
Psychomotor agitation or retardation
Vegetative signs
Chronic pain
Religious beliefs and spirituality
Mental status exam
Affect
Thought process (can’t problem solve, memory and concentration problems, maybe delusional)
Mood/feelings (hopeless and helpless!!)
Communication (can’t get point across, don’t belong, inattention)
Hygiene and dress
Sleep habits
Bowel habits
Decreased libido from low serotonin and norepi
Number one predictor of suicide
hopelessness
Recovery model with depression
Focus on patient’s strengths (have you ever experienced this before, gives idea of where they’re at)
Treatment goals mutually developed (patients need to be involved in meetings and treatment plan)
Based on patient’s personal needs and values
Planning
Phases of treatment and recovery
1.Acute– 6-12 weeks
2.Continuation–4-9 months
3.Maintenance–1 year and beyond
When do people w depression see improvement
Clinical benefits at least 1-3 weeks after initiation. Some people have response in 8-10 days but it’s usually 3 weeks which is a long time.
Trial of meds for depression
Adequate trial of meds is 6-9 months. Doctor says you need to stay on meds for 6-9 months even if you feel well after 3 weeks. Sometimes they get off the med or lower the dose after the 9 months, some eventually come off in 12 months. Some people stay on it
How are antidepressants chosen?
Family history, genetics, the Es of taking it (easy bc side effects, eat [watch what you eat])
Sometimes people are so used to being in depressive body state and the meds make you jittery and anxious and you stop taking them. Need to go through this to make you feel better. Not all meds do this though, but the ones that do are pretty severe
SSRIs
Selective serotonin reuptake inhibitors
First-line therapy
block uptake of serotonin so more is available at synapses, other indications such as OCD, and Panic Disorder
Came out third
SNRIs
Serotonin norepinephrine reuptake inhibitors
SSRIs may be tolerated better
Came out last
Tricyclic antidepressants
Anticholinergic adverse reactions
Came out in like ‘59
inhibit reuptake norepinephrine and serotonin (makes mood better)
Monoamine oxidase inhibitors
Came out in 50s, first to come out
Effective for unconventional depression
Breaks down neurotransmitters (dopamine, norepinephrine, and serotonin)
Monoamine oxidase breaks them down so they can’t attach and get synapse connection to make them feel better. MAOIs prevent the breaking down
Used to be first-line therapy but not anymore because of cardiac effects Now it’s a last resort. It’s good if you can commit to diet
Side effects of SSRIs
agitation, sleep disturbance, tremor, sexual dysfunction (causes med inherence), headache, autonomic effects
Toxic effect of SSRIs
serotonin syndrome!!
Abdominal pain, diarrhea, increased
BP, HR, temp; delirium, muscle spasm, irritable, may lead to shock/death
caution when use 2 antidepressants or herbal supplement (Esp. MAOI)
Washout period between two antidepressants (2 weeks)
Therapeutic dose reached after how long with tricyclics
Therapeutic dose reached 2-8 weeks (will have some effect sooner)
Side effects of tricyclics
anticholinergic, postural hypotension, tachycardia
Toxic effects of tricyclics
cardiac rhythm, heart block, MI (lots of elderly pts got this med, cardiac effects seen. Doesn’t happen with everyone but still serious
Drug interactions with tricyclics
MAOI, barbiturates, disulfiram, oral contraceptives and estrogen, alcohol, antihypertensives (clonidine, reserpine)
Contraindications of tricyclics
Cardiac issues but tiny amounts help with back pain (neuropathic response instead of antidepressant
MAOI diet
Adhere to a restrictive diet of foods and drugs (tyramine free)
Tyramine involved which can cause HTN crisis, can’t eat pickled foods, herrings, pickles, chocolate, aged cheeses/wines/beers
Indications of MAOIs
Those individuals with atypical depressions, all other meds and nothing worked for them (hypersomnia and overeating, anxiety disorders)
Side effects of MAOIs
orthostatic hypotension, weight gain, cardiac rhythm changes, insomnia, fatigue, anticholinergic
Toxic effects of MAOIs
hypertensive crisis (tyramine), need to monitor vital signs
Don’t use MAOIs if you have cardiac history and can’t adhere to diet
How to get esketamine and what r we watching
Have to go to an esketamine center where licensed practitioners administer the nasal spray. Pt comes in, kind of like OR setup, monitored for HTN every 30 mins. Someone has to drive them home. Used for people with acute suicide, helps very much with symptoms
no food 2 hrs before and no liquid 30 mins before treatment
Side effects of esketamine
high BP, dissociation, dizziness, vertigo, sedation, numbness, anxiety, and feeling drunk, out of body experience with ketamine so esketamine isnt as bad, they feel outward though
Dosing of esketamine
twice weekly for 4 weeks, tapering once a week for 4 weeks, week 9 and after once every week or two
Brexanolone
Zulresso
antidepressant
1st and only FDA approved med for ppd- schedule II drug
Neuroactive steroid 60 hour IV infusion. It is a one time infusion
Side effects of brexanolone
hypoxia, excessive sedation, and potential LOC. patients are continuously monitored
Antidepressants in pregnancy
inconclusive some preterm esp with bipolar manic phase
congenital malformations MAOI and TCA
SSRI in first trimester some risk
Antidepressants in children/adolescents
black box warning suicidal risk, despite less prescriptions suicide increased. What are the implications?
Ages 15-25, brain doesn’t stop growing until 25
Weren’t being given these because of black box and ended up suiciding even more, so they put it back
Antidepressants in older adults
Polypharmacy and metabolism issues
ECT
Electroconvulsive Therapy
Mini OR setup, bilateral (less confusion) or unilateral (more confusion but quicker recovery). Electrodes used
Indications of ECT
most common depression up to 90% remission, suicidal thoughts, psychotic disorders, failure to respond to meds
Informed consent (6-8 treatments from this consent), education for patient and family
How to do ECT (meds)
anesthetic (barbiturate (brevital) and muscle paralyzing agent (Succinylcholine), EEG and EKG monitoring, brief seizure induced via electrodes (uni- or bilateral)
Adverse reactions of ECT
confusion (will last some period of time or never goes away), headache, memory deficits (can get better or maybe wont)
If MAOI doesn’t work this is the last resort
PACU after ECT
PACU certified nurse needs to watch pt
When anesthesia lets pt go to next level of care, they go to PACU so they need PACU certified nurse, psych doesn’t have this
TMS
Transcranial Magnetic Stimulation For those unresponsive to other treatments, pregnancy, outpatient, electrode deliver magnetic pulses, noninvasive
Good if they don’t want ACT
Strong magnet but not as strong as MRI, literally just under it
Looking at cerebral cortex, results within 2 weeks
Vagus nerve stimulation
electrical stimulation boosts neurotransmitters, implanted in chest (surgical procedure) and attached to vagus nerve in neck, treatment-resistant depression
Deep brain stimulation
implanted electrodes in underactive brain areas, device (stabilizer) in chest wall, also works for parkinson’s
Light therapy
first line treatment for Seasonal Affective Disorder (SAD)
Very specific bulb, lux bulb
Useful for when we fall back, darker early, not out as much
Depressed for the 6 months until spring
Sometimes people just use this or they supplement with meds
St John’s Wort
increases serotonin, norepinephrine and dopamine
Careful with serotonin syndrome!!
Exercise for depression
increases serotonin, decrease HPA axis (thought to be overly active in depression)
30-45 minutes a day, 5 days a week. For mild to slightly mild-moderate depression
If you’re in the middle or severe-moderate depression, it won’t work for you
Healthy People 2030 goals for depression
improved screening, reduce depression incidence and increase treatment options and compliance (75% people with depression will receive treatment)
What do suicidal people need
Ideation, intent, and plan
Red flag law
Need to confiscate the gun and report it to the state. Local authorities come to you and take the gun so the hospital/whatever place doesn’t deal with it
2-2-2 rule
Highest risk 2 days before admission, 2 days after admission, and 2 days after discharge
2 days after discharge, they have some energy and the meds haven’t kicked in yet
Suicidal ideation
Thinking about killing oneself
Completed suicide
Suicide successfully resulting in death
Nonsuicidal self-injury
Self-injury directed to the surface of the body to induce relief from a negative feeling/cognitive state or to achieve a positive mood state
Suicide can happen by accident
SUICIDE IS NOT THEIR INTENT
Highest suicide rates in who
Active duty service members
THEY HAVE ACCESS TO A GUN! FEELING HOPELESS AND HELPLESS
Gender, age, race, religion, marriage, profession, physical health, and history r/t suicide
Males more often successfully suicide, females attempt more
Increase in 50-75. Most common in adolescents 10-34
White people
decreased in religious and ppl married with CHILDREN
Increased in professionals
Half have a physical illness
PRIOR ATTEMPTS AND LETHAL PLAN