Exam 2 Flashcards
What is zoonosis
an infection or infectious disease transmissible under natural conditions from vertebrate animals to humans
what is a vector
an insect or any living carrier that transports an infectious agent from an infected individual or its wastes to a susceptible individual or its food or immediate surroundings
what is vector-borne infection
interaction between the infectious agent and the human host
examples of zoonotic diseases
rabies, anthrax, salmonellosis, hantavirus, plague
examples of vector borne diseases
malaria, leishmaniasis, plague, lyme disease, and rocky mountain spotted fever
Malaria
- present in more than 100 countries
- more than 50 percent of the world population is at risk
what are the infectious agents of malaria
Parasitic Protozoan
- plasmodium falciparum - most deadly
- plasmodium vivax
- plasmodium ovale
- plasmodium malariae
transmission of malaria
- complex life cycle of mosquitos , the vector, and human hosts
- transmitted through the bite of an infected mosquito of the anopheles type
- symptoms of malaria occur approximately 9-14 days after being bit by an infected mosquito
costs of malaria
Direct Costs
- treatment
- disease prevention
Other Costs
- lost productivity
- lost earnings
- negative impact on tourism and agricultural labor
Estimated global direct economic costs - 12 billion USD annually
How has malaria been controlled
- in the US, malaria was endemic until the end of the 1940s
- use of DDT and synthetic antimalaria drugs found to be efficacious in the mid-20th century
-DDT no longer used due to the harm caused to wild life - south africa still sprays DDT annually, but only indoors
what causes leishmaniasis and what are the three forms
- parasitic disease caused by the protozoa, Leishmania
- three forms- visceral, mucocutaneous, and cutaneous
leishmaniasis transmission
- cutaneous form is transmitted from the reservoir to the human host by a sand fly
- after being bitten by the fly, the human host develops distinctive sore skin that forms after an incubation period of several weeks or months
environmental factors associated with observed increases in leishmaniasis
- movement of human population into endemic areas
- increasing urbanization
- extension of agricultural projects into endemic areas
- climate change due to global warming
leishmaniasis control methods
- periodic application of long-acting insecticides to dwelling units
- use of screens to prevent sand flies from entering housing
- elimination of breeding areas for the phlebotomus fly
- destruction of rodent burrows and control of domestic dogs
what causes the plague and what are the symptoms
- bacterium yersinia pestis infects both animals and humans
- called black death during the middle ages
- begins with non specific symptoms
plague transmission
- transmitted by the bite of a flea harbored by rodents
- respiratory droplets from a pneumonic plague infected person can transfer the bacterium to other individuals
plague control methods
- encourage the public to avoid enzootic areas, especially rodent burrows, and direct contact with rodents
- preventing rats from entering buildings and removing food sources that could enable rats multiply
- rats can be transferred onto ships in cargo containers
lyme disease transmission and treatment
- black legged ticks act as the disease transmission vector
- antibiotic exists for successful treatment if diagnosed in the early stages of the disease
Lyme disease
- caused by the bacterium Borrelia burgdorferi
- concentrated in the northeastern, mid-atlantic, and upper midwestern regions of the US
Rocky Mountain Spotted Fever
- caused by Rickettsia rickettsii - a rickettsial agent
- symptoms are sudden onset moderate-high fevers that may last up to three weeks
- case fatality rate is up to 25 percent of untreated patients
- treatable with antibiotics
- transmitted through bite of an infected tick
viral hemorrhagic fevers
- hantavirus pulmonary syndrome, dengue hemorrhagic fever, ebola
- a severe, multi system syndrome characterized by damage of overall vascular system and impairment of body’s ability to regulate itself. symptoms often accompanied by hemorrhage
- viruses that cause most infections are zoonoses; causative virus requires animal or insect host
- viruses are limited to geographic areas where the host species reside
arthropod-borne viral diseases
- group of viral diseases that can be acquired through the bite of blood-feeding arthropod vectors
- the cycle of transmission involves a non human vertebrate and an arthropod vector
- humans may or may not be part of the infection cycle
what are the four main clinical symptoms of arboviral disease
- acute central nervous system illness
- acute self-limited fevers, with and without rash
- hemorrhagic fevers
- polyarthritis and rash, w/wo fever and of variable durations
arboviral encephalitis
- caused by virus that produces acute inflammation of sections of the brain, spinal cord, and meninges
- majority of infections are asymptomatic. Presents as a mild illness with fever and headache, severe illness, high fever, disorientation, and death
- most arboviral encephalitis are transmitted by the bite of an arthropod- primarily mosquitoes
west nile fever
- caused by west nile virus, a mosquito borne viral fever
- etiology agent is flavivirus wnv, which can spread rapidly across wide geographic regions in the US
- neuroinvasive disease is the most severe form
- mosquitos become carriers after feeding on infected birds
emerging zoonoses
- zoonotic diseases caused by either new agents or known agents emerging in areas or species previously unaffected by them
factors associated with the rise of emerging zoonoses
- Ecological changes resulting from agricultural practices, such as deforestation, conversion of grasslands, irrigation
- Human population and behavior changes
Hantavirus pulmonary syndrome
- severe and sometimes fatal respiratory condition
- hantavirus is the causative agent
- main host and vector- north american deer mouse
- transmitted through inhalation of aerosolized urine and droppings from infected rodents
Dengue fever
- caused by the falviviruses
- dengue hemorrhagic fever is life-threatening fever with abdominal pain and bleeding phenomena
- dengue shock syndrome is potentially fatal
- transmitted through mosquito bite
- affected areas are primarily tropical and subtropical areas
zika virus
- mosquito borne, linked with developing febrile rash and has been associated with adverse birth outcomes in women infected while pregnant
ebola viral hemorrhagic fever
- people get ebola through contact with the bodily fluids of an infected dead person
rift valley fever
- caused by the phlebovirus
- can produce epizoodic or widespread disease through mosquitoes among domestic animals, and infected mosquitos transmit rvf to humans
- can also be contracted through the bodily fluids of infected animals
- endemic areas for rvf include south africa, sub-sarahan africa, and madagascar
other zoonotic disease
- monkeypox
- anthrax; caused by spore forming bacterium and commonly occurs among herbivores
- rabies, caused by virus transmitted through saliva from the bites of infected animals
- tularemia; rabbit fever; bacterial disease broadly distributed in the US linked with wild animals like rodents and hares
- Psittacosis (parrot fever): infectious disease associated with bacterial agents and conveyed by dried bird droppings
- Flu A virus
control and prevention of mosquito-born diseases
- use sentinel chickens and birds to monitor for the presence of viruses
- Drain standing water
- introduce mosquito-eating fish into ponds
- wear repellants and protective clothing
- repair window screens
dioxin is in agent orange and caused by the burning process
what do toxic metals include
heavy metals like lead, mercury, nickel and other metallic compounds like aluminum, iron, and tin
how much do heavy metals exceed the specific gravity of water
five or more times
what are the effects of acute exposure to toxic metals at high levels
- rapid onset of dramatic and severe symptoms
- symptoms based on ingestion; gastrointestinal
- symptoms based on inhalation; neurological effects
Effects of chronic exposure to toxic metals at lower levels - reduced cognitive functioning
- difficult to differentiate from those of chronic medical condition
CERCLA priority list of hazardous substances
a rank of hazardous substances that pose the most significant potential threat to human health
National Priority List NPL
- prioritized by ATSDR and EPA
- lists most serious uncontrolled or abandonded hazardous waste sites in the United States identified for possible long-term remedial action under superfund
five metals in the top 20 hazardous substances
- Arsenic
- Lead
- Mercury
- Cadmium
- Chromium
types of media people can be exposed to metal through
air, soil/dust, water, biota/food
heavy metal effects in women
- differences due to hormonal and metabolic processes
- some toxic heavy metals have the ability to cross the placental barrier, with the potential to cause fetal brain damage
heavy metal exposure effects in children
- more hazardous due to small body weight
- toxic effects may be irreversible
toxic effects include: - impairment of physical and mental development
- damage to internal organs and the nervous system
- some forms of cancer
- mortality
what is the classification of major toxic metals
metals that are toxic to life forms and not necessary to sustain life
- As, Pb, and Hg
what is the classification of essential metals with potential for toxicity
metals that are considered essential for life when present in trace amounts, but amounts greater than trace levels have the potential to be toxic
- Fe, Cu, Mn, and Zn
what is the classification for metals related to medical therapy
metals used in medical therapy
bioaccumulation
toxic substances become more concentrated and potentially more harmful as they move up the food chain
properties and exposure possibilities of arsenic
- acutley poisonous material that is ubiquitous in nature - in soil and water
- by product of refining gold and other metals. Has been used in pesticides, wood preservatives, and some manufacturing
- inhalation and ingestion can occur through industrial process or drinking contaminated drinking water
health effects of arsenic
Non-cancerous
- peripheral vascular disease
- cerebrovascular disease
- cardiovascular disease
- adverse pregnancy outcomes
Cancer
- lung cancer
- skin, bladder, kidney, and liver
historical arsenic poisoning
- blackfoot disease in taiwan in 1950s
- miners and ag workers exposed through arsenic containing pesticides
- low-level chronic exposure associated with melanosis
characteristics and possible exposure sites of beryllium
- lighter than aluminum but stronger than steel
- workers in the metal industry are most likely to be exposed. Most frequent method of occupational exposure is inhalation
- general public exposure results from coal burning emissions
- emissions form coal-burning plants may contaminate agricultural products
health effects of beryllium
Non-Cancer
- inhalation can result in berylliosis, also known as chronic beryllium disease (CBD).
Cancer
- beryllium is a carcinogen for lung cancer
cadmium properties and possible exposure sights
- found in all soils and rocks and coal and fertilizers derived from minerals
- used in batteries. Released as a byproduct of the mining industry and manufacturing of fertilizers and pesticides
- fish, plants, and animals contain a certain amount of cadmium
primary sources of cadmium exposure
primary sources of environmental exposure:
- cigarette smoke
- vegetables grown in cadmium-containing soil
- bioaccumulates in shellfish
- some species of mushrooms
Occupational exposure to cadmium:
- production of nickel-cadmium batteries
- zinc smelting
- paint manufacturing
- soldering
- metal factories
Health effects of cadmium
Non-Cancer:
- osteoporosis
- loss of height
- kidney damage
- elevated BP
- Cardiovascular disease
- Itai-itai disease
Cancer:
- lung, trachea, and bronchus cancer
chromium properties and sources of exposure
- naturally occurring element in the earth’s crust
common forms of chromim: - Cr: from human industrial activities
- Cr3+: an essential nutrient
- Cr6+: from human industrial activities classified as a carcinogen
health effects of Cr6+
Non-cancerous:
- exposure via ingestion: digestive issues, damage to organs such as the kidney and liver
- topical exposure: skin ulcers
- exposure via inhalation: respiratory issues
Cancer:
- GI squamous cell carcinoma
- respiratory lung cancer