Exam #2 Flashcards
what is addiction?
a compulsive/abnormal behavior that relates to substances or behaviors
what is intoxication?
a state of disturbed cognition, perception, behavior, LOC, and judgment
what is withdrawal?
physiological and mental readjustment from stopping the use of an addictive substance
why is alcohol use accepted?
because it is legal, used in ceremonies, and religions
what is the blood alcohol level that can cause intoxication in a human?
80-100 mg/dL
what is the blood alcohol level that can cause death in humans?
400-700 mg/dL
what drugs are CNS depressants?
alcohol, sedatives, hypnotics, anxiolytics, cannabis,
what are sedatives used for?
anxiety, panic, seizures, and sleep disorders
what are hypnotics used for?
xxx
what are anxiolytics used for?
xxx
what are some signs of alcohol/sedative/hypnotic/anxiolytic intoxication?
disinhibition of sexual or aggressive behaviors
mood lability
impaired judgment and memory
impaired social/occupational function
decreased LOC
Slurred speech
Incoordination
Unseady
Nystagmus
Flushed face
what is nystagmus?
uncontrolled eye movements…can be up, down, left, right, etc
what are some chronic effects of alcohol abuse?
peripheral neuropathy, alcoholic myopathy, Wernicke encephalopathy, korsakoffs psychosis, alcoholic cardiomyopathy, esophagitis, gastritis, pancreatitis, hepatitis, cirrhosis of liver, leukopenia, thrombocytopenia, sexual dysfunction
what is peripheral neuropathy in relation to alcohol abuse?
nerve damage in the extremities
what does peripheral neuropathy feel like?
pain, burning, and tingling, in the extremities
what causes peripheral neuropathy?
having low amounts of the B vitamin Thiamine
why do alcoholics experience peripheral neuropathy?
because they have poor nutrition and malabsorption of food from alcohol
can peripheral neuropathy be reversed?
yes but can be permanent for some
how is peripheral neuropathy reversed?
by abstinence from alcohol and improvement in diet
what is alcoholic myopathy?
a condition that causes loss of function and strength in your skeletal muscles in response to long-term or heavy drinking
what are the symptoms in acute alcoholic myopathy?
sudden onset muscle pain, swelling and myoglobinuria
what is myoglobinuria?
occurs when myoglobin are present in the urine
why would myoglobin be present in urine?
it occurs in patients who have alcoholic myopathy due to their muscles breaking down….the body excretes the product of the breakdown in the urine
what are the symptoms of chronic alcoholic myopathy
gradual wasting and weakness of muscle tissue
is acute alcoholic myopathy reversible?
yes
is chronic alcoholic myopathy reversible?
no
what causes alcoholic myopathy?
having low amounts of the B vitamin thiamine
what color is myoglobinuria?
red tinged
what changes must be made to improve patients with alcoholic myopathy?
abstinence from alcohol and diet
what labs are elevated in patients with alcoholic myopathy?
aspartate aminotransferase (AST)
Alanine transaminase
(ALT)
what is Wernickes encephalopathy
the most serious form of thiamine deficiency that can cause death
what are the symptoms of Wernickes encephalopathy
death, paralysis of ocular muscles, diploplia, ataxia, somnolence, and stupor
what are the ocular muscles?
muscles that control your eyes
what is diplopia?
double vision
what is ataxia?
poor muscle control that causes clumsy movements
what is somnolence?
sleepy
what is a stupor?
state of unconsciousness that can be awakened with extreme stimulation
can wernickes be reversed?
yes
what is Korsakoff’s psychosis?
occurs when alcohol is abused the symptoms are confusion, recent memory loss, and confabulation
what other diseases is Korsakoff psychosis paired with?
Wernicke
is korsakoffs psychosis psychosis reversable?
no
what is alcoholic cardiomyopathy?
accumulation of lipids on the myocardial tissue causing the heart to be bigger and have weaker contraction
can alcoholic cardiomyopathy be fixed?
no
what does alcoholic cardiomyopathy mimic?
HF and arrhythmias
what are the symptoms of alcoholic cardiomyopathy?
decreased ability to exert, tachy, dyspnea, edema, palpitations, and nonproductive cough
what labs will be elevated in alcoholic cardiomyopathy?
AST and ALT
what are treatments for alcoholic cardiomyopathy?
abstinence from alcohol, rest, oxygen, digitization, sodium restrictions, diuretics
what is esophagitis?
inflammation of the esophagus
what is pancreatitis?
what is the alcohol hepatitis?
inflammation of the liver that causes it to be enlarged and tender
what is cirrhosis of the liver?
when fibrous scar tissue forms on the liver decreasing filtration and absorption
what are the symptoms of alcoholic hepatitis?
N/v, anorexia, weight loss, abd pain, jaundice, edema, anemia, blood coagulation problems
why does alcoholic hepatitis cause anemia and blood coag problems?
xx
what can be done to treat alcoholic hepatitis?
abstinence from alcohol, diet
what is leukopenia
the production, function, and wbc impaired
what does leukopenia put you at risk for?
infection
what is thrombocytopenia?
decrease in platelet production
what is sexual dysfunction in relation to alcoholism
women have decreased menstural cycles and libido
men have decreased test, gyno, and impaired fertility
how do we assess alcoholism?
CAGE questions
what does the C in CAGE mean
have you tried to CUT down
what does the A in CAGE mean?
have people ANNOYED by criticizing you?
what does the G mean in CAGE?
have you felt bad or GUILTY
what does the E in CAGE mean?
have you had an eye opener drink
in the CAGE question what constitutes someone might have be an alcoholic?
2 or more positive responses
when does alcohol withdrawal occur?
from 4-12 hours from last drink
what are the symptoms of alcohol withdrawal?
tremmors in hand, toungue, eye
N/v
Sweating
Malaise/weak
Elevated BP/HR
Anxiety
Irritability
Hallucinations
Delirium
Headache
Insomnia
Depression
seizures
Death
what precautions should you keep in mind with alcoholics going through withdrawal?
seizure
what should you have ready for a patient under seizure precautions?
suction, nonrebreather, benzo, padded rails, vital machine
what should you do if a seizure occurs?
check the time, roll the patient over, apply nonrebreather, use suction, administer lorazepam
what lab is being monitored for alcoholic in withdrawal?
BMP for fluid, electrolytes, and blood sugar
why should blood sugar be monitored in alcoholics?
alcohol damages the pancreas which releases insulin and also damages the liver which releases glucose into the blood stream
why are alcoholics at risk for seizures?
because alcohol is a CNS depressant and when the patient stops drinking their CNS activity goes much higher than what it is used to causing increased risk of seizures
what med groups are used as substitution therapy for alcoholism?
benzodiazepines and anticonvulsants
why are benzo and anticon used to treat alcoholism?
because it lowers the CNS activity to match where it was when they were drinking
what does the dosage timeline for substitution therapies look like?
start of with a higher dose and slowly taper away
what benzodiazepines are long acting?
chlodixepoxide and diazepam
what benzo is short acting?
lorazepam
what benzo should be given to those with chronic liver diseases?
the quick-acting one lorazepam
what are the anticonvulsants?
carbamazepine, valporic acid, lamotrigine, topiramate
what are the two types of deterrent therapies for alcoholism?
Disulfiram and naltrexone
how does Disulfiram work?
it causes the person taking the medication to become ill when ingesting alcohol
how long must a patient be abstinent from alcohol before taking Disulfiram?
minimum 12 hours
what is required from the patient before taking Disulfiram?
consent
what is the worst side effect of Disulfiram?
death
how long does it take for symptoms of Disulfiram to start if someone drinks?
5-10 minutes
what must the patient avoid when taking Disulfiram
alcohol, vanilla, mouth wash, nyquil, sanitizer
what are side effects the patient can anticipate if they drink while taking dilfucking fuck?
n/v, flushed skin, dizzy, sweating, tachycardia, resp depression, MI, death
how does naltrexone work for alcoholics?
blocks pleasure receptors in the brain
what can naltrexone be used to treat?
alcohol and opioid abuse
what therapies can alcoholics use?
AA, counseling, group therapy
what effects do sedatives/hypnotics/ anxiolytics have on the body?
changes in sleep/dreaming, hypotension, compromised contraction, reduced urine output, lower metabolism, reduced body temp, sexual function
when does withdrawal begin in short acting drugs?
begins in 12 to 24 hours
when does withdrawal peak in short acting drugs?
24 TO 72 HOURS
when does withdrawal subside in short acting drugs?
5-10 days