Exam 2 Flashcards
Cardiac muscle doesn’t require a nerve impulse beca
the heart uses an intrinsic method of conduction
Cardiac reserve
amount of extra blood that can be pushed through the heart when we need it to be
Stroke volume
amount of blood pushed out the heart during each beat
Stroke volume
end diastolic- end systolic
Cardiac output
SV x HR
Factors effecting stroke volume
stretch of cardiac muscle
Contraction strength
arterial pressure
Stretch of cardiac muscle
pre load
- the more blood in ventricles, more stretch, and stronger contraction
-causes ejection of more blood
-starling law of heart
Contraction strength
neither pre or post
-muscles can change its permeability to calcium which causes increase in strength of contraction
Arterial pressure
after load
-if there is increased pressure in the vessels, the heart cant’t push blood out because it has to go from high to low pressure
Cardiac output is what kind of variable?
homeostatic
If stroke volume increase, heart rate
slows down
Factors affecting heart rate
Parasympathetic nervous activation
Sympathetic nervous activation
Adrenal Medulla production of norepinephrine
Thyroxine
BP changes
Ionic balances
Age
Sex Exercise
Temperature
Parasympathetic nervous activation
releases acetlycholine, which causes hyperpolarization of the SA node. Makes it harder to create a pacemaker potential. slows it down
Sympathetic Nervous Activation
-releases norepinephrine, which causes the heart rate to increase.
-changes the sa node so it depolarizes faster
-increase in contractibility of the muscle
Adrenal Medulla production of norepinephrine
releases norepinephrine as a hormone
-increase in heart
Thyroxine
-increases cellular metabolic activity
BP changes
-detected by special receptors called baroreceptors
-if BP goes up, less blood can get out of the heart, so the heart needs to speed up
Ionic balances
-speed up or slow down heart rate depending on what we have
Age
-heart rate declines as you age->you wont be able to raise heart rate as high
Sex
females have a faster heart rate than males
Exercise
will go up, but if you continue long term aerobic exercise program, your resting heart rate will decrease
Temperature
heart rate goes up when you have a fever
Vagal escape
when heart starts racing when it shouldn’t be-> issue with vagal tone
Tachycardia
abnormally high resting heart rate >100BPM
Bradycardia
abnormally low resting rate <60BPM
Congestive Heart Failure
anything that causes abnormally low cardiac output
Coronary Atherosclerosis
coronary arteries: clogged from plague deposits
-stroke volume decreases, decreased amount of oxygen delivered to cardiac muscle-> can’t contract like it used to be
High Blood Pressure
Diastolic BP>90
-heart has to contract with greater force to eject the blood, decrease stroke volume and cardiac output
Myocardial Infarctions
Heart attack: oxygen supply to heart is eliminated temporarily-> loses contractibility bc lack of oxygen made it become fibrous connective tissue
-coronary arteries are blocked
Dilated cardiomyopathy
-too much blood in ventricles
-flappy ventricles
**What is the process called D-looping?
where the heart will flip upside down
-rightward bending of the heart
Where is the foramen ovale?
hole between right and left atria through the interatrial septum
Ductus Arteriosus locations
- connection between the pulmonary trunk and aorta, provides another shortcut in the embryo
- blood that didn’t take the shortcut to the foramen ovale, goes to right ventricle
- it is pumped into the pulmonary trunk where it goes through the connection of aorta
- Blood that would be going to the lungs, goes to the aorta itself
- seals after birth and becomes the ligamentum arteriosum
Age-related changes
valve sclerosis
decreased cardiac reserve
fibrosis of myocardium
Atheroscleroses
Valve sclerosis
deposits (calcium) accumulate on top of valve flaps, making them more rigid
-valves become less functional because it prevents them from closing all the way, so there is back flow of blood
-decreased cardiac out put
-offset by health diet, accumulates over time
Decreased cardiac reserve
as you age, you lose the ability to have a large cardiac reserve
-can be somewhat offset by exercise
Fibrosis of myocardium
-if you fail to use the myocardium, it will began atrophy and become non-contractible tissue
-prevent by staying active
Atherosclerosis
-accumulation of plague along inside of blood vessels
-reduces diameter of blood vessels, which changes blood pressure
Is are circulatory system open or closed?
closed
Arteries carry blood
away from heart
carry blood that is rich in oxygen
Exception: pulmonary artery
Elastic Arteries
-proximal to heart
-larger diameter
-have minimal resistance
-walls are rich in elastin which allows them to rebound to maintain the pressure in blood
EX: aorta or pulmonary artery
Muscular artery
-distal to heart
-smaller diameter
-branch of the pulmonary arteries and carry blood to our organs
-some elastin
Arterioles
-branches off of muscular arteries and lead to capillary beds
Capillaries
-compose of simple squamous epithelial tissue
-site of gaseous exchange
Veins
-return blood back to heart EX:vena cava
-carry blood that is poor oxygen
Exception: pulmonary veins
-more blood than anywhere else
-lowest pressure here
Lumen
opening in the middle of the vessel that contains the blood
Tunica interna
composed of simple squamous epithelium
-cells bind to create a flat surface that is as smooth as possible
Tunica media
middle layer, deep to tunica interna
-smooth muscle and elastin
-thick in arteries
-blood vessel diameter controlled subconsciously through sympathetic nervous system
Tunica Externa
-deepest
-made up of collagen and dense irregular
-anchors blood vessels in place
Vasa Vasorum
blood vessels for blood vessels; tiny blood vessels that feed into tunica externa, found in largest blood vessels
Capillaries
small enough that each blood cell has to go through single file
Continuous Capillaries
-most common
-epithelial cells, endothelium is very tightly joined, have intercellular clefts, must go through walls for exchange
-pinocytic vesicles
Located: skin, muscle, most places in the body
Fenestrated Capillaries
-has pores called fenestration that increase permeability across wall of capillary
Location: high absorption and filtration rates
EX: kidneys, endocrine organs, small intestines, digestive track
Sinusoidal capilaries
-bigger openings, leakiest, blood can pass through the walls.
Location: liver and bone (red bone marrow)
Terminal Arteriole
sends blood to capillary bed, can change blood flow by changing its..
Metarteriole
branches off terminal arteriole
Thoroughfare channel
becomes postcapillary venule, main middle channel
Postcapillary Venule
Thoroughfare channel empties into this and returns blood to the vein
Vascular Shunt
combo of metaartiole and thoroughfare channel, MUST always be open
True capillaries
branches off arterioles, where gas exchange occurs
Microcirculation
regulates the amount of blood going through capillary beds
Precapillary Sphincters
-helps open or close individual capillaries
-can be partially open to control amount of blood passing through->regulate micro-circulation within the body
Artery (walls, lumen, tunica media, blood volume, blood pressure, valves)
thick
small
thick
lower
higher
no valves
Veins (walls, lumen, tunica media, blood volume, blood pressure, valves)
thin
large
thinner
higher
lower
venous
How much percentage is in our veins?
65%
Blood in veins is under what pressure?
low
Muscular pump
-as we contract our muscles they change shape and push against the walls of the vessels
-pushes blood up in the direction of the heart
Respiratory pump
-as we breathe, we have a change in the pressure of our thoracic cavity
-as we inhale the blood can slip up to low pressure place close to the heart
Collateral channels
-multiply supply channels that connect to each other (called anastomosis)
-go to places that need greater blood supply
-if one channel got blocked there would still be a path to come through
**Our body tries to maintain what in blood flow
cardiac output
Blood flow is what proportional
directly proportional to differences in blood pressure
-the greater the pressure, greater amount
Blood flow is inversely proportional to what?
peripheral resistance
-due to friction
-flows more easily with less friction through a large vessel
Blood viscosity definition
change in slipperiness through the walls of vessels
-higher viscotiy, slower flow
EX:honey
Vessel length description
longer vessel=more resistant
larger people have longer vessels
Vessel diameter description
larger diameter has less friction so it is less resistant
**arterioles change the most
determines blood flow