Exam 2 Flashcards
What is the function of ACh and how is it removed from the synaptic cleft?
What are the two major typed of AChRs?
What are the structural and functional differences between AChRs?
Facilitation
Depression
rapid decrease in synaptic strength during sustained synaptic activity
How long does synaptic depression last?
hundreds of milliseconds
mechanisms of synaptic depression
depletion of readily releasable pool (RRP) of synaptic vesicles
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V
declined NT release
How is synaptic depression correlated to the amount of transmitter release?
more transmitter release = more depletion of readily releasable vesicles
Augmentation and Potentiation
after repeat synaptic activity, increase in synaptic strength over a longer time scale than synaptic facilitation
How long does augmentation last
over a few seconds
How long does potentiation last?
tens of seconds to minutes
Mechanisms of augmentation
elecation of presynaptic calcium levels
Synaptic Plasticity
the ability of synapses to strengthen or weaken synaptic transmission in response to neural activity over time
Short term plasticity
changes last for a few minutes or less
Increased synaptic strength due to enhanced NT release leads to:
synaptic facilitation, augmentation, and potentiation