Exam 2 Flashcards
Which nerve is implicated in the Chvostek’s sign?
Facial
What is the function of the immune system?
to remove foreign antigens such as viruses and bacteria to maintain homeostasis
What 2 labs are specific to measuring an inflammatory response?
WBC
CRP or ESR - markers for inflammation
Natural immunity
NONSPECIFIC RESPONSE TO FOREIGN INVADERS
WBC - release cell mediators such as histamine, bradykinin and prostaglandins and engulf foreign substances
inflammatory response
Physical barriers
Acquired immunity
Results of prior exposure to an antigen
active or passive
Active immunity is
Immunologic defenses developed by persons own body
Active immunity is
Immunologic defenses developed by persons own body
Passive immunity
Temporary
Results from a transfer of a source outside of the body
Ex. transfer of antibodies from mother to infant, injections
What leukocytes are assoc with inflammation?
Neutrophils
What are the 4 stages of immune response?
-Recognition - Lymph for surveillance/Macrophages
-Proliferation - Lympho stims T and B and they enlarge, divide and turn into cytotoxic or antibodies
-Response -
-Effector -
HUmoral immunity
Interplay of antibodies
Cellular immunity
cytotoxic T cells
Research shows that stem cells can
Restore an immune system that has been destroyed
Immune deficiency is acquired in what 2 ways?
-Due to medical treatment such as chemotherapy
-Infection from agents such as HIV
HIV-1 is transmitted through what body fluids?
Blood & Blood products
Seminal fluid
Vaginal secretions
Mother-to-child: amniotic fluid, breast milk
What is the prevention education for HIV & AIDS
-Behavioral interventions
-HIV testing
-Linkage to treatment and care
What is reproduction education for HIV?
Artificial insemination
ART -
Refrain from breastfeeding
What is the confirmatory testing for HIV
Western blot test
What precautions are used with HIV patients?
Standard precautions
HIV is in the subfamily of lentiviruses and is a ——– virus?
Retrovirus bc it carries genetic material in the form of RNA rather than DNA
HIV targets cells with
CD4+ receptors - which are expressed on the surface of T lymphocytes, monocytes, dendritic cells and brain microglia
What are the steps in HIV life cycle?
Attachment
Uncoating/fusion
DNA synthesis
Integration
transcription
translation
Cleavage
Budding
What is Stage 0
Early HIV, inferred from lab testing
What is Stage 1 HIV
–The period from infection with HIV to the development of HIV-specific antibodies
-Dramatic drops in CD4 T cell counts normally 500 to 1500 cells/mm3 of blood
What is the CD4 T cell count determinant for AIDS?
Below 200
What is Stage 2 HIV?
Occurs when T lymphocytes are between 200-499 cells/mm3
What is Stage 3 HIV?
When CD4 T cell count drops below 200
*AIDS
What is the main symptom for later stages HIV/AIDs
Respiratory manifestions
SOB, dyspnea, cough, chest pain
–Pneumocystis pneumonia
TB
What are the GI manifestions of HIV
Loss of appetite
Oral candidiasis
diarrhea
wasting syndrome
What are oncologic manifestations of HIV?
Kaposi sarcoma
Aids related lymphomas
What are the neurologic manifestations of HIV
Effects on cognition, motor function, attention, visual, memory
Peripheral neuropathy
HIV encephalopathy
Fungal infections - cryptococcus neoformans
Depression and apathy
What are the integumentary manifestations of HIV?
Herpes zpster
Seborrheic dermatitis