Exam 1 Protozoans Giardia Flashcards
intermittent H2O D (NO BLOOD), cramps, distended stomach, pain, anorexia, B12 def, MALABSORPTION due to flat villi
Giardia Lambia
Giardia Lambia
Tear drop B12 H2O born (thru feces) ROCKY Mntns Troph = 2 n INF cyst = 4 n - Doesn't invade, no blood
Ingest INF CYST (INF STAGE), EXCRYSTATION IN STOMACH (cyst disintegrates and releases trophs), IN LARGE BOWEL, TROPHS ENCYST (neutral pH and bile salts - signal that conditions not good); pass thru feces
-Flat villi -> MALABSORBTION
Sx: intermittent H2O D (NO BLOOD), cramps, distended stomach, pain anorexia, B12
Self limiting, STI
Flat villi that lead to MALABSORPTION
Giardia Lambia
Water borne and ROCKY Mnts
Giardia Lambia
EXCYSTATION in STOMACH,
ENCYSTATION in LARGE BOWEL
Ingestion of CYST is infectious stage
Giagdia Lambia
EntAMOEBA hystolitica
TROPH: 1 n
Cyst: 4 n (INF)
Sx: dysentery to systemic, blood in D, fever, vomid, cramps, wgt loss, ULCERS - URQ pain, acute colitis, LIVER ABCESS
1) encysts and passed in feces or
2) colonized mucosa of colon and invades blood - DISSEMINATION
VIRULENCE:
Lectin - adheres
phospholipase - disrupts membrane
amebapore - inserts ion channels - lyses cells
Cystein proteases- degrade mucus, ABs, complemets, matrix
RESISTANT TO CLORINE/ STI
Which has 4 virulence factors; lectin, phospholipase, amebapore, cystein protease?
EntAMOEBA hystolitica
Liver abscess (RUQ pain) is in
AntAMOEBA hystolitica
Feeds on blood, invasive, can be systemic
EntAMOEBA hystolitica
Which bacteria are RESISTANT TO CHLORINE?
EntAMOEBA hystolitica, CRYPROspofidium hominus or C. Parvum (h+bovine), CYCLOspora CAYEtunesis (caynne)
CRYPTOsporidium Hominis (humans only) and C. Parvum (h+bovine)
INTRACELLULAR but EXTRACYTOPLASMIC
INF Oocytes hold 4 sporozoites (also Inf) (motile, bind to epith cell of int)
DOESN”T MULTIPLY OUTSIDE HOST
-creates barrier from cytoplasm (dense layer)
1) INF oocytes ingested into PARASITOPHOROUS VACUOLE (near surface of cell)
2) SEXUAL and Asex REPRODUCTION - produce INF oocytes:
thin walled oocytes reinfect host (don’t leave)
thick walled oocytes released into env’t
Sx: H2O D, wgt loss, fever, wasted, pain, lasts 2 weeks, self limiting, high in kids,
DX: can acid fast, ELISA, immunofluorescence, oocytes in stool
-in swimmers
-via H2O and feces, Pto P, feces to oral
Sx: watery D for 2 weeks, fever, wgt loss, pain, high in KIDS and SELF-LIMITING
CRYPTOsporidium Hominis or C. Parvum
which bacteria can do Acid Fast
CRYPTO and CYCLOspora cayetanesis
PARASITOPHOROUS VACUOLE
near surface of epithilial cell of int - where CRYPTO inserts and is separated from cytoplasm by dense layer
INTRACELLULAR BUT EXTRACYTOPLASMIC
CRYPTO
which bacteria causes B12 deficiency
Giardia
Which bacteria doesn’t multiply outside the host?
CRYPTOsporidium Hominis or Parvum
which bacteria is prevalent in swimmers
CRYPTOsporidium Hominis and Parvum
CYCLOspora Cayetanesis (cayenne)
-Latin America
-AUTOFLUORESCENT OOCYST
-LARGE SIZE
-H2O AND IMPORTED FRUIT
- OOCYTES SHED IN FECES MUST SPORULATE In Envt fb infectious (5-7 days)
sx: EXPLOSIVE watery D (no blood), low fever, cramps, nausea, vomit, fatigue
Dx: large oocysts in stool, Autofluoresce, Acid fast +, PCR avail
RESISTS CHLORINE
Which bacteria has Explosive watery D (no blood), low fever, cramps, nausea vomint, fatigue
CYCLOspora Cayenne
Which has to ahve oocytes shed thru feces SPORULATE for 5-7 day in envt before INF?
CYCLOspora Cayenne
Which bacteria autofluoresce?
CYCLOspore Caynne
BLASTOcytis Hominis
Large vacuole with MULTIPLE N’s
- via animal feces in H2O and food
polymorphic
BALANtidium Coli (BARAN)
MACRONUCLEUS and cilia (one but huge nucleus)
zoonic (pigs)
gut perforation
in large intestine
