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GI 2 Exam 1 > Exam 1 Pharm: Nausea & Vomiting > Flashcards

Exam 1 Pharm: Nausea & Vomiting Flashcards

1
Q

Suffix for Serotonin (5-HT3) Receptor antagonists

A

-setron

Dolasetron
Granisetron
Ondansetron
Palonosetron

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2
Q

Suffix for Neurokinin (NK1) Receptor Antagonists

A

-pitant

Aprepinant (prodrug Fosaprepitant)
Netupitant (prodrug Fosnetupitant)
Rolapitant

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3
Q

Diphenhydramine drug class

A

Histamine (H1) receptor antagonist

Diphenhydramine (Dimenhydrinate metabolizes to Diphenhydramine)
Hydroxyzine
Promethazine
Meclizine
Cyclizine
Doxylamine/B6
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4
Q

Dimenhydrinate drug class

A

Histamine (H1) receptor antagonist

Diphenhydramine (Dimenhydrinate metabolizes to Diphenhydramine)
Hydroxyzine
Promethazine
Meclizine
Cyclizine
Doxylamine/B6
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5
Q

Hydroxyzine drug class

A

Histamine (H1) receptor antagonist

Diphenhydramine (Dimenhydrinate metabolizes to Diphenhydramine)
Hydroxyzine
Promethazine
Meclizine
Cyclizine
Doxylamine/B6
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6
Q

Promethazine drug class

A

Histamine (H1) receptor antagonist

Diphenhydramine (Dimenhydrinate metabolizes to Diphenhydramine)
Hydroxyzine
Promethazine
Meclizine
Cyclizine
Doxylamine/B6
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7
Q

Meclazine drug class

A

Histamine (H1) receptor antagonist

Diphenhydramine (Dimenhydrinate metabolizes to Diphenhydramine)
Hydroxyzine
Promethazine
Meclizine
Cyclizine
Doxylamine/B6
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8
Q

Cyclizine drug class

A

Histamine (H1) receptor antagonist

Diphenhydramine (Dimenhydrinate metabolizes to Diphenhydramine)
Hydroxyzine
Promethazine
Meclizine
Cyclizine
Doxylamine/B6
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9
Q

Prochlorperazine drug class

A

Dopamine (D2) Receptor Antagonist

Prochloreperazine
Olanzapine
Metoclopramide
Amisulpride

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10
Q

Olanzapine drug class

A

Dopamine (D2) Receptor Antagonist

Prochloreperazine
Olanzapine
Metoclopramide
Amisulpride

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11
Q

Metoclopramide drug class

A

Dopamine (D2) Receptor Antagonist

Prochloreperazine
Olanzapine
Metoclopramide
Amisulpride

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12
Q

Amisulpride drug class

A

Dopamine (D2) Receptor Antagonist

Prochloreperazine
Olanzapine
Metoclopramide
Amisulpride

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13
Q

Scopolamine drug class

A

Muscarinic (M1) Receptor Antagonist

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14
Q

Dronabinol drug class

A

Cannabinoid (CB) Receptor Agonist***

only antiemetic class that is a receptor agonist

Dronabinol
Nabilone

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15
Q

Nabilone drug class

A

Cannabinoid (CB) Receptor Agonist***

only antiemetic class that is a receptor agonist

Dronabinol
Nabilone

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16
Q

Serotonin (5-HT3) Receptor Antagonist indications

A

multiple etiologies of N/V

17
Q

*Most worrisome adverse effect in serotonin receptor antagonist use

A

Dose dependent QT prolongation (Dolasteron highest risk)

*extreme caution required for use in pts on other QT prolonging agents

18
Q

Longest lasting serotonin receptor antagonists

A

Palonosetron and Granisetron

19
Q

Neurokinin-1 Receptor Antagonist indication

A

Most effective in combination therapy for N/V in chemotherapy pts

20
Q

*Histamine (H1) receptor antagonist adverse effects

A

Classic Anticholenergic Effects

CNS depression
Dry mouth
Constipation
Urinary retention
Blurred vision
Decreased BP
21
Q

Histamine receptor (H1) Antagonist therapeutic uses

A

multiple etiologies of N/V

  • Doxylamine/B6 1st line for pregnancy N/V
  • Meclizine or Cyclizine only indicated for motion sickness/vertigo
22
Q

Dopamine receptor (D2) Antagonist therapeutic uses

A

multiple etiologies of N/V

  • Amisulpride only for postoperative N/V after other treatments have failed (expensive)
  • Metoclopramide in pts with N/V and GI dysmotility
23
Q

Drug to treat N/V in pt who gets motion sickness while fishing on a boat and doesnt want to be taking tons of pills

A

Scopolamine (M1 Receptor Antagonist)

  • patch worn for 72 hours
  • treat motion sickness in deep sea fisherman
24
Q

M1 Receptor Antagonist (Scopolamine) adverse effects

A

Classic Anticholenergic Effects

CNS depression
Dry mouth
Constipation
Urinary retention
Blurred vision

*decreased BP not on slide for this one

25
Q

Cannabinoid (Dronabinol/Nabilone) MOA

A

STIMULATES cannabinoid receptors (mostly C1), GPCR signal transduction decreases excitability of neurons, minimizes serotonin release

26
Q

*Cannabinoid (Dronabinol/Nabilone) indications

A

FDA scheduled drug, commonly reserved for treatment resistant N/V in chemotherapy patients

27
Q

*Treatment regimen for N/V in patient on HIGH-EMETOGENIC chemotherapy regimen

A
  1. D2 receptor antagonist
  2. NK1 receptor antagonist
  3. Serotonin receptor antagonist
  4. Corticosteroid (Dexamethazone)

Ex:

  1. Olanzapine
  2. -pitant
  3. -setron
  4. Dexamethazone
28
Q

*Treatment regimen for N/V in patient on MODERATE-EMETOGENIC chemotherapy regimen

A
  1. NK1 receptor antagonist
  2. Serotonin receptor antagonist
  3. Corticosteroid (Dexamethazone)

Ex:

  1. -pitant
  2. -setron
  3. Dexamethazone

*just drop the D2 antagonist

29
Q

*1st line treatment for N/V in pregnancy

A

Doxylamine/B6 (H1)

1st line for pregnancy N/V

30
Q

*Treatment for vertigo

A

Meclizine (H1) or Cyclizine (H1) (Vertigo)

31
Q

*Treatment for motion sickness

A

Scopolamine patch (M1)
Dimenhydrinate (H1) or
Meclazine (H1)

for motion sickness

32
Q

Treatment for patient w/ postoperative N/V after other treatments have failed

A

Amisulpride

only for postoperative N/V after other treatments have failed (expensive)

33
Q

Treatment for diabetic patient w/ N/V and gastroparesis/GI dysmotility

A

Metoclopramide

in pts with N/V and GI dysmotility

GI 2 Exam 1 (7 decks)

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