Exam 1 Clinical DSAs Flashcards
Esophageal perf due to to a medical procedure (NG tube placement, ednoscopy)
Iatrogenic esophageal perf
Esophageal perf due to retching, alcohol use, Boerhaave’s
Spontaneous esophageal perf
Presents as chest pain, subcutaneous emphysema, Hamman’s sign (crunching sound when listening to heart)
GI life threatening chest pain:
Esophageal perf
Angina, chest/epigastric pain, confirmed by ECG
Non-GI life threatening chest pain:
MI
Sudden onset chest pain, SOB, hypoxia, hypercoaguable state, sinus tach on ECG
Non-GI life threatening chest pain:
PE
Sudden onset chest/back pain, widened mediastinum on CXR, hypotension if popped
Non-GI life threatening chest pain:
Aortic dissection
Chest pain, coffee ground emesis, hematemesis, melena, hematochezia
GI life threatening chest pain:
PUD
Infectious esophagitis:
EGD shows large, shallow, superficial ulcers, biopsy with inclusion bodies
CMV infection
Tx: Gancyclovir, start ART in HIV pt
Infectious esophagitis:
EGD shows multiple small deep ulcers, also has oral ulcers
HSV infection
Tx: acyclovir
Infectious esophagitis:
EGS shows diffuse, linear yellow white plaques adherent to the mucosa
Candida infection
Tx: systemic therapy i.e. fluconazole
Chest pain, hypertensive esophageal peristalsis (contractions too powerful) with greater amplitude and duration, normal relaxation but elevated baseline pressure
Nutcracker esophagus
Chest pain (retrosternal), multiple spastic contractions in the esophagus, uncoordinated esophageal contraction, barium swallow shows corkscrew or rosary bead esophagus
Diffuse esophageal spasm
Esophageal disorder secondary to GERD, weak LES, stomach acid damages esophagus, may progress to Barrett esophagus
Reflux esophagitis
Chest pain (retrosternal), allergic or atopic condition, eosinophilia, esophageal rings on EGD
Eosinophilic esophagitis
Tx: swallow glucocorticoids
Esophageal disorder caused by taking oral medication without water while supine (commonly in hospitalized pts)
Pill induced esophagitis
Prevention: take meds w/ water
Complications of eosinophilic esophagitis
Food impaction, perforation, stricture
Esophageal disorder caused by ingestion of alkali or acid solution
Caustic esophagitis
Accidental (children)
Deliberate (suicidal)
Prevention of pill induced esophagitis
Take pills with water, dont give oral meds to pts with esophageal dysmotility/dysphagia/strictures
Caustic esophagitis Tx
Stabilize, ICU, supportive care, EGD to assess extent of injury
Caustic esophagitis DO NOT
NO nasogastric lavage to flush out (risk of re-exposure)
NO corticosteroids or abx
Dysphagia localized to the neck
Oropharyngeal dysphagia
Dysphagia localized to the chest
Esophageal dysphagia
Oropharyngeal dysphagia, progressive, bad breath, barium swallow before EGD due to risk of perforation
Zenker diverticulum
Complication = perforation
Oropharyngeal or esophageal dysphagia, intermittent symptoms, not progressive, Barium swallow shows thin diaphragm-like membranes, Plummer-Vinson syndrome association
Esophageal web (proximal)
[Shatzki ring (distal)]
Iron deficiency anemia, esophageal webs, glossitis, angular cheilitis
Plummer-Vinson Syndrome
*webs increase SCC risk
Dry mouth and eyes, swollen salivary glands, + anti SSA/Ro or anti SSB/LA abs, esophageal motility probs
Sjogren’s syndrome
Sjogrens syn complicatinos
Oral/esphageal candida, B cell non-Hodgkin lymphoma
Structural esophageal dysphagia, intermittent and not progressive, food bolus impaction, barium swallow shows ring at gastroesophageal junct
Schatzki ring
Complication: food bolus impaction
Structural esophageal dysphagia, secondary to GERD, but heartburn symptoms are improved
Esophageal stricture
Esophageal cancer in middle 1/3 of esophagus, progressive dysphagia, risk factors = smoking + acohol
Esophageal SCC
Tx: esophagectomy (surgery)
Esophageal cancer in distal 1/3 of esophagus, progressive dysphagia, risk factors = Barrett esophagus
Esophageal adenocarcinoma
Tx: endoscopic ablation
Esophageal dysphagia due to abnormal motility, loss of NO producing inhibitory neurons in myenteric plexus, birds beak on barium swallow
Achalasia
Dx by esophageal manometry
Achalasia due to spontaneous or unknown cause
primary achalasia
Achalasia due to Chagas dz
secondary achalasia
Esophageal dysphagia due to abnormal motility, caused by smooth muscle fibrosis, CREST syndrome, Scl-70 (diffise) and anti-centromere abs (limited)
Scleroderma
Esophageal stricture progression of symptoms
Dysphagia progressively worsens, heartburn progressively improves
Complication of longstanding GERD, intestinal metaplasia of lower esophagus that may progress to esophageal adenocarcinoma, typically asymptomatic
Barrett esophagus
Prevention of Barrett esophagus to adenocarcinoma
PPI > H2 blocker
endoscopic ablation
surveillance endoscopy
Imminent desire to vomit
nausea
forceful expulsion of gastric contents through the mouth
vomiting
gentle expulsion of gastric contents in the absence of nausea and diaphragmatic contraction
regurgitation
regurgitation, rechewing and reswallowing of food from the stomach
ruminatoin
N/V, constipation, intermittent abdominal pain; most commonly caused by adhesions; high pitched tinkling bowel sounds, dx w/ KUB XR
small bowel obstruction
Postprandial fullness, N/V, possibly due to CN X damage, retention observed on gastric emptying study
gastroparesis
May be caused/exacerbated by diabetes mellitus, controlling blood sugar may help prevent
Extraperitoneal N/V etiologies
Labrinthine Dz: CN VIII problem
Intracerebral: mass, SAH
Psychiatric
Medications (side effects)
Always do this lab in a female pt of childbearing age presenting with N/V
Urine pregnancy test or beta-hCG blood test
Alarm features of GERD
Constant/severe pain, dysphagia/odynophagia => needs further workup with endoscopy, imaging, surg consult
Others: weight loss, dehydration, vomiting, mass, hematemesis, IDA
Typical GERD symptoms
heartburn, relationship w/ meals, leaning back, etc.
Atypical GERD symptoms
Asthma, chronic cough, aspiration
GERD management
PPI > H2 blocker
Lifestyly modifications
Inflammatory changes to gastric mucosa due to an imbalance between defense and acidic environment; caused by alchohol, medications, etc.
Acute gastritis
Inflammatory changes to gastric mucosa caused by H. Pylori or autoimmunity
Chronic gastritis
Autoantibodies against parietal cells and/or intrinsic factor
Type A chronic gastritis
gastritis caused by H. Pylori in the antrum of the stomach
Type B chronic gastritis
H. Pylori detection
Upper endoscopy with gastric biopsy for H. Pylori (done first)
Fecal antigen test, urea breath test used to confirm eradication
Gram - curved rod that produces urease, Cag-A toxin
H. Pylori