Exam 1 pharm Flashcards

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1
Q

Acetylcholine fxns

A

Movement, memory

- Def: Alzheimer’s

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2
Q

Dopamine

A

Movement, reward center
Def-< parkinsonism
Surplus-> schizophrenia and addictive behaviors

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3
Q

Ne

A

Alertness, arousal

Def-> Depressive disorders

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4
Q

Serotonin 5 HT

A

Mood, evidence of sleep

Def-> depression, OCD, ED

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5
Q

GABA

A

Awake arousal and regulates anxiety levels
Def-> Anxiety disorders, seizures/tremors,
imnsomnia

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6
Q

Gutamate

A

Fxn-> memeory and learning

Surplus-> schizoprhenia, seizures, migranes

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7
Q

Endirphins

A

-imitate opiate receptors and pain relief

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8
Q

Dopaminergic/ psychotic/ RF s and SE

A
  • TARDIVE DYSKENSIA!! usually from 1st gen Clozapine *Clozaril)
  • This is why 2nd gen are often used to less SE risk
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9
Q

consideration for mergency meds

For IM meds->
Haloperidol (Haldol)
Ziprasidone (Geodone)
Olazapine (Zyprexa)

A
  • For IM olanzapine do not give with lorazepam and be given at least 1 hour apart!!
  • Less risk associated with EPS with olanzapine and ziprasidone
  • When given IM Zyprexa’s serum is 5x more concentrated and potent
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10
Q

First gen Antipsychotics

A

D2 antagonist

  • Higher rates of EPS/ Tardive dyskinesia
  • symptoms -> may be debiliting and affect walking, breathing, eating and talking
  • Elderly are at higher risk
  • AIMS tetsing and monitotring
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11
Q

2nd gen antipsychotics

A
  • 5HT2A/ D2 antagomsists
  • lower rates of EPS
  • Higher ratesof metabolic SE
    risk of DM, hyperchlosterimaia, BMI,body circumference
  • Educaiton of diet
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12
Q

Clozapin montiroing

A
  • associated with risk for agranulocytosis
  • requires managment within a lab monitoring program
  • weekly blood monitroing for 1st 6months
  • Biweekly monitroing for next 6 months
  • Tx w/o hematological problems can be performed monthly
  • Also leads to high risk of seizures
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13
Q

Neuroliptic MAlignant syndrome

A

Symptoms: High fever, sweating, anxiety, Tachycardia, arrhythmia, alterations on blood pressure

  • can lead to multi-organ failure, aspiration, hypoxia
  • edcuate on switching meds carefully
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14
Q

Serotonin is the pricipal NT in what

A

in Stress, anxiety, depression

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15
Q

SSRIs

A
  • Fluoxetine, citalopram, escitalopram, paroxetine, setraline
  • SE: Nausea, Insomnia, anxiety, tremors, sexual dysfunciton
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16
Q

SNRIs

A

Duleoxetine, Venlafaxine, desvenlafaxine

- Nausea, Tired, fatigue, dry mouth

17
Q

TCAs

A

SE-> Drowsiness,arrthymia, QTc alteractions, blurry viision, seizures
- clomipramine, amytrypiline, nortripyline,doxepin, impramine

18
Q

MAOIs

A

Selgiline

- Dietary restictions -> cancause increased tyramine levels and HTN crisis

19
Q

SARIs

A

trazodone, vortioxwtine, vilazoone

- decrease serotinin related SE

20
Q

mirtazapine

A

Noradenergic antagonist blcoks epi recpetors

21
Q

Symbax

A

Combo drug og prozac and Zyprexa

- tx of bipolar disorder depression

22
Q

Wellbutrin

A

Dopamine reuptake inhibitor. Tx of depression, SAD, smoking

SE: Dizziness, dry mouth. N/v, blurry vision, wt gain, sex dysfunction

23
Q

Serotinin Syndrome

A
  • AMS, autonomic hyperactivity, neuromuscular abnormalities

- stop meds, procide supportive therapy, tx symptoms

24
Q

Durgs for mania

A
  • atypical antipsychotics are gold stanadar for mania
25
Q

Lithium levels

A

0.6-1.2
toxic is over 1.5
monitor for sedation, cognitive impairment, tremor, wt gain, rash
Long term-> alteartion in thyroid level

26
Q

drugs for anxiety

A

SSRI-> risk for transient anxiety at first
Setraline, citalopram, paroxetine-> may be used in high anxiety disorder patinets
Buspirone-> can be good as PRN but takes 2-3 weeks to beocme evident
venlafaxine-> Effective in trating insomnia, poor concetration, restlessness, irritability, and excessive muscle tension associated with GAD
Benzos-> use with caution, watch for sedatin, respiratory depression, advise against driving
TCAs-> impriminenine
Antihistamines-> hydroxyzine
- sedation but lesser extent
B- adnergic antagonists -> propranolol
Tx duration-> 6-12 months

27
Q

Benzos onset

A

very rapid high risk of adiction and short life

- do not stop rapidly

28
Q

ADHD pharma

A
  • Psychostimulants are the 1st line and cornerstone
    Methlyphenidate and amphetamine salts
    SE-> worsended sleep, decreased apetite, psychisis, increased dopamine
  • can decrease anxiety
  • zombie- Look think about restriction esp in children
29
Q

Non stimulant ADHD

A
  • Stattera atmoxetine
  • noradernergic agent reuptake inhibitor
  • decreased risks in some populations espcially psychotic symptomatology
  • SE-> liver injury monitor
30
Q

Alpha-2 no stimulant

A
  • > can improve cognitive fxn and improve HTN

- > more receptive to NE