Exam 1 pharm Flashcards
Acetylcholine fxns
Movement, memory
- Def: Alzheimer’s
Dopamine
Movement, reward center
Def-< parkinsonism
Surplus-> schizophrenia and addictive behaviors
Ne
Alertness, arousal
Def-> Depressive disorders
Serotonin 5 HT
Mood, evidence of sleep
Def-> depression, OCD, ED
GABA
Awake arousal and regulates anxiety levels
Def-> Anxiety disorders, seizures/tremors,
imnsomnia
Gutamate
Fxn-> memeory and learning
Surplus-> schizoprhenia, seizures, migranes
Endirphins
-imitate opiate receptors and pain relief
Dopaminergic/ psychotic/ RF s and SE
- TARDIVE DYSKENSIA!! usually from 1st gen Clozapine *Clozaril)
- This is why 2nd gen are often used to less SE risk
consideration for mergency meds
For IM meds->
Haloperidol (Haldol)
Ziprasidone (Geodone)
Olazapine (Zyprexa)
- For IM olanzapine do not give with lorazepam and be given at least 1 hour apart!!
- Less risk associated with EPS with olanzapine and ziprasidone
- When given IM Zyprexa’s serum is 5x more concentrated and potent
First gen Antipsychotics
D2 antagonist
- Higher rates of EPS/ Tardive dyskinesia
- symptoms -> may be debiliting and affect walking, breathing, eating and talking
- Elderly are at higher risk
- AIMS tetsing and monitotring
2nd gen antipsychotics
- 5HT2A/ D2 antagomsists
- lower rates of EPS
- Higher ratesof metabolic SE
risk of DM, hyperchlosterimaia, BMI,body circumference - Educaiton of diet
Clozapin montiroing
- associated with risk for agranulocytosis
- requires managment within a lab monitoring program
- weekly blood monitroing for 1st 6months
- Biweekly monitroing for next 6 months
- Tx w/o hematological problems can be performed monthly
- Also leads to high risk of seizures
Neuroliptic MAlignant syndrome
Symptoms: High fever, sweating, anxiety, Tachycardia, arrhythmia, alterations on blood pressure
- can lead to multi-organ failure, aspiration, hypoxia
- edcuate on switching meds carefully
Serotonin is the pricipal NT in what
in Stress, anxiety, depression
SSRIs
- Fluoxetine, citalopram, escitalopram, paroxetine, setraline
- SE: Nausea, Insomnia, anxiety, tremors, sexual dysfunciton