Exam 1: PD/PK Flashcards
The drug effect is r/t
the number of bound receptors. With the greatest effect being when all receptors are bound, ex. paralytics
Types of bonds
ion (opposite charged ions)
Hydrogen
Van Der Waals interaction
Antagonist
binds to receptor but doesn’t activate it
Competitive Antagonism
increasing amounts progessively inhibits the agonist. Shifts dose response curve to the right.
Non-competitive antagonism
Even high concentrations of agonist cannot cause the agonist effect
Partial agonist
Causes less response than the agonist even at supramaximal doses
inverse agonist
compete for the same site as the agonist but produce the opposite effect
Does the number of receptors change
Number of receptors are not static. They increase and decrease depending on drug therapy and comorbidity
What is tachyphylaxis
tolerance. An example of tachyphylaxis is seen with ephedrine which develops rapid tolerance.
Other examples of decreased receptors include:
Albuterol treatment for asthma (down regulation of receptors due to repetition)
Pheochromocytoma (decreased Beta receptors in response to catecholamines)
Pharmacokinetics is what
what the body does to the drug. Includes ADME.
Pharmacokinetics is what kind of study
Quantitative. Determines the amount or concentration of the drug.
Pharmacokinetics also help determine:
The amount of druge needed to reach the plasma level where the desired effect is seen.
What proteins do acidic drugs bind to
albumin
What proteins do alkalotic drugs bind to
A1-Acid Glycoprotein
