Exam 1: MEDS Flashcards
NSAIDs MOA
- interfere with biosynthesis of prostaglandins. (too many prostaglandins inc sensitivity of pain)
- COX inhibitors
- Selective (COX-1 and -2) and non-selective
Side effect of NSAIDs
-GI
Motrin
- Ibuprofen
- NSAID
codeine
opioid
-analgesic
Toradol
- ketorolac tromethamine
- NSAID
feldene
- piroxicam
- NSAID
Opioids - MOA
- analgesic
- inhibit synaptic transmission by dec neurotransmitter release from the presynaptic terminal and dec the excitability of the postsynaptic neuron within key pain pathways in the spinal cord and brain
adverse opioid side effects
-sedation, euphoria, slower respiratory rate, orthostatic hypotension, GI, addition?
Morphine
- opioid
- analgesic
Demerol
- meperidine
- opioid
- analgesic
hydrocodone
- hycodan
- opioid
- analgesic
oxycodone
- OxyContin
- opioid
- analgesic
Voltaren
- diclofenac
- NSAID
Relafen
- nabumetone
- NSAID
darvon/darvocet
- propoxyphene
- opioid
- analgesic
Acetaminophen (type, what they do, examples)
- analgesic
- not anti-inflammatory or anti-coagulation effects
- excedrin and tylenol
Valium (name, MOA, group, side effects)
- diazepam
- muscle relaxant
- MOA: inc inhibitory effects of GABA on alpha motor neuron activity in spinal cord
-adverse effects: sedation, tolerance and dependence
Polysynaptic inhibitors (MOA, Side effects)
- muscle relaxants
- MOA: not well defined. dec activity in polysynaptic pathways that lead to the alpha motorneuron. also cause global dec in CNS excitability
-Side effects: sedation, nausea, light headedness, vertigo, headache
Flexeril
- chlorzoxazone
- polysynaptic inhib (muscle relaxant)
Paraflex/parafon forte
- chlorzaxazone
- polysynaptic inhib (muscle relaxant)
skelaxin
- metaxalone
- polysynaptic inhib (muscle relaxant)
Soma
- carisoprodol
- polysynaptic inhib (muscle relaxant)
Steriods - oral and injection. Glucocorticoids MOA
-inhibit the transcription and expression of adhesion molecules which are responsible for attracting leukocytes to endothelial cells at the side of inflammation
Glucocorticoids - side effects
- renal function, general catabolic effect on muscles, bone, ligament, and tendon with chronic use.
- injections usually limited to max 3
