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PHA 416 - Therapeutics IV > Exam 1 - HIV Infection > Flashcards

Exam 1 - HIV Infection Flashcards

1
Q

What is the term that describes an indirect reflection of the number productively infected cells in the body as a whole?

A

Viral RNA

-A proportion between plasma viral RNA and the amount of virus in the fixed lymphoid tissues

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2
Q

T/F: HIV RNA levels appear more predictive of progression of HIV than CD4+ counts.

A

TRUE

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3
Q

Name the different utilities of HIV RNA assays.

A
  • Assessing baseline status in newly diagnosed HIV patient
  • Assessing response to therapy
  • Assessing development of resistance to current therapy
  • Reductions in plasma viremia correlates with increased CD4+ cells and AIDS-free survival
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4
Q

According to Dr. Destache, how long does it take to reach a non-detectable level/load?

A

~4-6 months for a viral load of 20

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5
Q

When should you measure plasma HIV RNA?

A

In all HIV-1 infected patients at baseline and on a regular basis thereafter

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6
Q

What is the minimal change in viral load considered to be statistically significant?

A

A threefold or 0.5 log10 copies/mL change

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7
Q

What is the optimal viral suppression generally defined as?

A

A viral load below the level of detection (<200 copies/mL)

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8
Q

With Antiretroviral regimen, when is viral suppression achieved?

A

In 12-24 weeks viral suppression will be achieved

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9
Q

When should you monitor plasma viral load?

A
  • At initiation OR change in therapy (within 2-4 weeks)
  • In virologically suppressed patients in whom therapy was modified because of drug toxicity or regimen simplification
  • In patients on a stable ARV regimen (repeat viral load Q3-4 months OR as clinically indicated - can extend interval to Q6 months for adherent patients with suppressed viral loads for more than 2-3 years and whose clinical and immunologic status is stable)
  • Monitor in patients with a sub-optimal response to therapy (those that cannot get to un-dectable level)
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10
Q

What are the treatment goals for HIV treatment?

A
  • Reduce HIV-associated morbidity and prolong the duration and quality of survival
  • Restore and preserve immunologic function
  • Maximally and durably suppress plasma HIV viral load
  • Prevent HIV transmission
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11
Q

What are the four questions that need answers for HIV therapy?

A

1) When to initiate therapy?
2) Which type of drugs to use?
3) When to change therapy?
4) Which drugs to use when changing therapy?

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12
Q

T/F: Mother-to-child transmission of HIV does not occur.

A

FALSE - mother-to-child transmission of HIV does occur

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13
Q

T/F: For the most part, everyone gets 2 NRTIs.

A

TRUE

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14
Q

Cobicistat is a _____ for Elvitegravir.

A

Cobicistat is a BOOSTER for Elvitegravir.

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15
Q

What is the brand name for the following combination of drugs:

Efavirenz + Tenofovir disoproxil + Emtricitabine

A

Atripla

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16
Q

What are the 3 drugs in Atripla?

A

1) Efavirenz
2) Tenofovir disoproxil
3) Emtricitabine

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17
Q

What three drugs are in Biktarvy?

A

1) Bictegravir
2) Tenofovir alafenamide
3) Emtricitabine

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18
Q

What is the brand name of the drug that has the following combination:

Bictegravir + Tenofovir alafenamide + Emtricitabine

A

Biktarvy

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19
Q

What 2 drugs are included in Cabenuva?

A

1) Cabotegravir

2) Rilpivirine

20
Q

What is the brand name of the following combination:

Cabotegravir + Rilpivirine

A

Cabenuva

21
Q

What 3 drugs are included in Complera?

A

1) Rilpivirine
2) Tenofovir disoproxil
3) Emtricitabine

22
Q

What is the brand name of the following combination of drugs:

Rilpivirine + Tenofovir disoproxil + Emtricitabine

A

Complera

23
Q

What 3 drugs are included in Delstrigo?

A

1) Doravirine
2) Tenofovir disoproxil
3) Lamivudine

24
Q

What is the brand name for the following combination of drugs:

Doravirine + Tenofovir disoproxil + Lamivudine

A

Delstrigo

25
Q

What two drugs are included in Dovato?

A

1) Dolutegravir

2) Lamivudine

26
Q

What is the brand name of the following combination of drugs:

Dolutegravir + Lamivudine

A

Dovato

27
Q

What 4 drugs are included in Genvoya?

A

1) Elvitegravir
2) Cobicistat
3) Tenofovir alafenamide
4) Emtricitabine

28
Q

What is the purpose of Cobicistat?

A

To serve as a booster for Elvitegravir; has no HIV activity itself

29
Q

What is the brand name of the following combination of drugs:

Elvitegravir + Cobicistat + Tenofovir alafenamide + Emtricitabine

A

Genvoya

30
Q

What 2 drugs are included in Juluca?

A

1) Dolutegravir

2) Rilpivirine

31
Q

What is the brand name of the following drug combination:

Dolutegravir + Rilpivirine

A

Juluca

32
Q

What are the 3 drugs in Odefsey?

A

1) Rilpivirine
2) Tenofovir alafenamide
3) Emtricitabine

33
Q

What is the brand name of the following combination of drugs:

Rilpivirine + Tenofovir alafenamide + Emtricitabine

A

Odefsey

34
Q

What are the four drugs included in Stribild?

A

1) Elvitegravir
2) Cobicistat
3) Tenofovir disoproxil
4) Emtricitabine

35
Q

What is the brand name for the following combination of drugs:

Darunavir + Cobicistat + Tenofovir alafenamide + Emtricitabine

A

Symtuza

36
Q

What is the brand name for the following combination of drugs:

Dolutegravir + Abacavir + Lamivudine

A

Triumeq

37
Q

What is the brand name for the following two drugs:

Cabotegravir + Rilpivirine IM shots

A

Cabanevua

38
Q

What is the generic of Rukobia?

A

Fostemsavir

39
Q

What is the brand name for Maraviroc?

A

Selzentry

40
Q

What is the brand room for Ibalizumab?

A

Trogarzo

41
Q

T/F: HIV-infected patients with CD4+ counts <200 are at higher risk of opportunistic infections/diseases, non-AIDS mortality, and death.

A

TRUE

42
Q

What is the name of the type of testing done in order for a patient to take Abacavir?

A

HLA-B*5701 testing

-Testing to see if patient is at risk for fatal hypersensitivity reaction

43
Q

According to the NIH how many drugs are in the regimen for ARV-naive patients?

A

2 or 3-drug regimen

44
Q

T/F: Integrase Strand Transfer Inhibitors are the preferred treatment.

A

TRUE

45
Q

What is the regimen for patients that are HLA-B*5701 negative?

A

Dolutegravir/Abacavir/Lamivudine (Triumeq)

46
Q

Name the four other regimens of Integrase Inhibitors, outside of the regimen that is for patients who are able to take Abacavir.

A

1) Dolutegravir + either Tenofovir disoproxil fumurate/Emtricitabine OR Tenofovir alafenamide/Emtricitabine
2) Dolutegravir +

PHA 416 - Therapeutics IV (10 decks)

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