Exam 1 EXTRAS

Question 1

How is a drug distributed throughout the body after intravenous injection? (ie central compartment to peripheral compartments) Give examples of vessel-rich groups, vessel poor groups, etc.

Answer 1

After intravenous injection, the drug is distributed through the VESSEL-RICH groups first, if not immediately eliminated.
Vessel rich groups: heart, lungs, liver, kidneys brain.
From vessel rich groups to muscle
Muscle to fat
Vessel-poor groups: tendons, connective tissue, bone, cartilage.

Question 2

How much cardiac output do vessel-rich groups receive?

Answer 2

75% of our total cardiac output

Question 3

How much cardiac output do muscles receive?

Answer 3

19% of our total cardiac output

Question 4

How much cardiac output does fat receive?

Answer 4

6% of our total cardiac output

Question 5

How much cardiac output do vessel-poor groups receive?

Answer 5

0%

Question 6

What factors will affect the Vd?

Answer 6

• blood volume: high BV, high Vd. Low BV, low Vd
• Protein-binding: high protein binding, low Vd.
• Low circulating proteins: higher Vd
  -lipophilic drugs = high Vd, hydrophilic drugs= low Vd

Question 7

What are examples of weak acid drugs?

Answer 7

ASA, NSAIDs, warfarin, barbiturates

Question 8

What are examples of weak base drugs?

Answer 8

LA’s, Opioids, beta-blockers