Dexmedetomidine Flashcards
What areas of the brain does dexmedetomidine work in?
Pontine, locus coeruleus
What is the antagonist for dexmedetomidine?
Atipamezole
Dexmedetomidine is a full alpha-2 agonist. Is clonidine a full alpha-2 agonist?
No; partial agonist
What is dexmedetomidine’s E1/2 time?
Where is it metabolized?
Excreted?
2-3 hours
Liver
Kidneys
What adverse effects can occur with dexmedetomidine?
hypotension with high doses, bradycardia with rapid infusion, cardiac arrest
What is the sedation dosing for dexmedetomidine?
0.2-0.7 mcg/kg/hour IV
What is the regional anesthetic dosing of dexmedetomidine?
0.5 mcg/kg with lidocaine
What is the neuraxial spinal dosing of dexmedetomidine?
5 mcg with fentanyl, 25 mcg alone
What is the epidural dosing of dexmedetomidine?
2 mcg/kg
What is the TIVA/GETA dosing for dexmedetomidine?
Bolus 0.5-1 mcg/kg over 10 minutes
0.1-1.5 mcg/kg/min infusion
HIGH DOSE
5-10 mcg/kg/hour IV
