Exam #1 Diuretics

Question 1

Site of action of Mannitol?

Answer 1

Proximal Tubule (PT)

Question 2

Site of action of excess glucose?

Answer 2

Proximal Tubule (PT)

Question 3

Site of action of Furosemide?

Answer 3

Ascending Thick Limb of LOH

Question 4

Site of action of Chlorothiazide?

Answer 4

Early Distal Tubule (DT)

Question 5

Site of action of Amiloride?

Answer 5

Collecting Duct (CD)

Question 6

Site of action of Spironolactone?

Answer 6

Collecting Duct (CD)

Question 7

MOA of Mannitol?

Answer 7

Osmotic diuretic

Question 8

MOA of excess glucose?

Answer 8

Osmotic diuretic

Question 9

MOA of Furosemide? What does it block?

Answer 9

Loop diuretic

- Blocks NKCC2

Question 10

MOA of Chlorothiazide? What does it block?

Answer 10

Thiazide diuretic

- Blocks NCC

Question 11

MOA of Amiloride?

Answer 11

Blocks ENaC

Question 12

MOA of Spironolactone?

Answer 12

Inhibits action of Aldosterone

Question 13

Two PK’s of Mannitol?

Answer 13

• IV administration

- Concentration dependent

Question 14

What must occur for excess glucose to work?

Answer 14

Filtered Load (FL) must exceed Tubular Maximum (Tm)

Question 15

What is a powerful class of diuretics?

Answer 15

Furosemide

Question 16

What is the primary action of Chlorothiazide?

Answer 16

Enhances Ca2+ reabsorption in Distal Tubule (DT)

Question 17

Are Loop Diuretics or Thiazide Diuretics more potent?

Answer 17

Loop Diuretics are MORE potent

Question 18

What is the primary action of Amiloride?

Answer 18

Inhibits Na+ reabsorption in Collecting Duct (CD)

Question 19

What is the primary action of Spironolactone?

Answer 19

Binds to intracellular receptor for Aldosterone