Exam 1 - Acute MI Pharmacology

Question 1

initial treatment

Answer 1

• oxygen
• morphine
• aspirin
• nitroglycerin
• beta-blocker
• thrombolytic agent

Question 2

fibrinolytic therapy

Answer 2

• alteplase (tPA)
• most effective
• works best within 30-70 minutes

Question 3

MOA of alteplase

Answer 3

dissolves clot by converting plasminogen into plasmin

Question 4

main side effect of alteplase

Answer 4

bleeding

Question 5

when is alteplase contraindicated

Answer 5

history of brain bleed

Question 6

what is alteplase always given with

Answer 6

heparin and anti platelet therapy

Question 7

nitroglycerin

Answer 7

• severe hypotension
• do not administer with sildenafil

Question 8

reperfusion injury

Answer 8

• rapid restoration of blood flow to the myocardium also contributes to injury because of myocardial stunning
• caused by oxidized free radicals generated by WBCs and the cellular response to restored blood flow