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P1-f FoundPharm > Exam 1 > Flashcards

Exam 1 Flashcards

1
Q

drug labeling is regulated by

A

FDA; Prescribing information/package insert

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2
Q

What is the intent of the design of the package insert

A

To simplify the format of the package inserts to make them more “user-friendly” and practical. The ultimate intent is to improve safety and drug efficacy

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3
Q

overt or covert promotion of off label uses is

A

prohibited

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4
Q

Physicians Desk Reference

A

compilation of package inserts for major brand name products

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5
Q

Drug facts and comparisons

A

organizes drugs by therapeutic class and cost

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6
Q

AHFS drug infomration

A

evaluates drugs

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7
Q

Somatic pain

A

localized pain

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8
Q

Visceral pain

A

deeper pain

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9
Q

NSAID treatment of neuropathic and psychosomatic pain

A

low response

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10
Q

Nociceptive pain

A

acute, signal of tissue damage

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11
Q

Endings of non-narcotic analgesics

A

-profen and -fenac

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12
Q

salicylate

A

precursors to NSAIDs

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13
Q

pharmacologic classification of NSAIDs

A

Cox inhibitor (related inhibition of protaglandins)

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14
Q

Properties of NSAIDs

A

Analgesic, antipyretic (fever), anti-inflammatory

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15
Q

Aspirin is the name for

A

Acetylsalicylic Acid

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16
Q

aspirin irreversibly inhibits

A

platelet function (8-10 days)

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17
Q

Max dose of aspirin

A

3.9G q 24h

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18
Q

Aspirin dosage

A

325 to 650 mg q4h

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19
Q

DDI for aspirin

A

warfarin and NSAIDs

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20
Q

Asprin for children

A

not recommended (life threatening condition possible): Reye’s syndrome - following a virus

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21
Q

Non-selective inhibitor of cyclo-oxyenase (COX)

A

inhibits COX 1 and 2

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22
Q

Ibuprofen Brands

A

Advil, Motrin

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23
Q

Naproxen

A

Naprosyn, Aleve

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24
Q

Diclofenac

A

Voltaren

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25
Opthalmic NSAIDs
Bromfenac, nepafenac
26
Keterolac
Toradol, short term <5d relief of moderately severe pain (can compare to morphine), good for post op pain
27
Forms of ketorolac
Tablets, injection (IV or IM), Intranasal
28
Partially selective inhibitors of COX
Etodolac and Meloxicam
29
Benefits of partially selective inhibitors
less likely to cause platelet aggregation or GI bleeding
30
ADRs of NSAIDs
Coagulation disordees, increeased risk of mascarriage (should be avoided during 3rd trimester)
31
Reye's syndrome
in aspirin
32
Severe but rare adverse skin reactions
Stevens Johnson syndrome, Toxic Epidermal Necrolysis
33
Excedrin Migraine
Aspirin, acetaminophen, caffeine
34
COXIBs are
the most selective of the NSAID class, no cardio side effects
35
generic for Celebrex
celecoxib
36
Indications for celecoxib
Osteoarthritis and RA, Dysmenorrhea, Familial Adenomatous Polyposis (reduce proliferation of polyps in the colon)
37
contraindications - celecoxib
caution in patients at risk for stroke and heart attack; contraindicated in patients who have had open heart surgery
38
acetaminophen brand
Tylenol
39
acetaminophen is the selection of choice for
12 yo andyounger, pregnant 3rd trimester, GI toxicity risk, patients on warfarin or other anticoagulant
40
max daily dose of acetaminophen
4000mg in 24h (12 tablets 325mg or 8 tablets extra strength; for patients consuming more than 3 alcoholic beverages per day dose should be less
41
counseling tips for acetominophen
take with food, is effective but not as effective as NSAIDS, do not combine products
42
acetaminophen toxicity
may result in hepatoxicity
43
opioid now refers to
all narcotic pain killers, naturally or synthetically derived
44
Phenanthrenes
Morphine, Codeine, Heroin (diacetylmorphine), hydromorphone, hydrocodone, benzhydrocodone, oxycodone, oxymorphone, levorphanol, naloxone, buprenorphine
45
Phenylpiperadines
Fentanyl, Alfentanil, remifentanil, sufentanil, meperidine
46
Diphenylheptanes
Methadone
47
Side effects of opioids
Analgesia, Euphoria/Diysphoria, Respiratory Depression, Physical Depression, Sedation - CNS depression, Miosis - pupillary constriction, Reduction in GI motility
48
Strong Agonists
Alfentanyl, Fentanyl, Heroin, Meperidine, Morphine, Remifentanil, Sufentanil, hydromorphone, levorphanol.
49
Moderate/Low Agonists
Codeine, Oxycodone, Hydrocodone, Benzhydrocodone.
50
Mixed Agonists
Buprenorphine, Butorphanol, Pentazocine
51
Antagonists
Naloxone, Naloxegol, Naltrexone
52
Other analgesics
Tramadol, Tapentadol
53
Classifications of pain for opioid use
Acute pain (severe only), non cancer chronic pain, chronic cancer pain, neuropathic pain (usually doesn't respond to NSAID but may respond to antidepressants)
54
Opioid applications other than analgesia
Anasthesia, palliative sedation, antidiarrheals, antitussives
55
Chronic compulsive use of opioids
Opioid use disorder
56
Stupor
Reduced consciousness
57
PDMP
Prescription Drug Monitoring Programs
58
REMS
Risk evaluation and mitigation strategy : Educational resources for prescribers, medication guides
59
DEA Status
Controlled substance status
60
Prescription Blanks for controls
DEA +NPI, serial number, One per blank, Telephone not allowed for CII, Post dated blanks for 90 day supply, 30 day limit to fill prescription (not 1y),
61
Refilling CII
no refills
62
Refilling CIII-V
5 refills within 6 months
63
Partial filling of Controls
DEA allows it, but remainder must be provided within 72 hours
64
Quantity limits
120 units for 30 days
65
Initial prescriptions for acute non cancer pain, opioid naiive
5 day supply
66
How to identify a valid prescription
Red and Green Flags
67
Labeling for opioids
Cautionary Labels, Federal Law prohibits transfer
68
Opioid Dosage Guidelines
start with min dose, route of administration, immediate vs controlled release, patient factors
69
Abuse deterrent formulations
Resist crushing or dissolving, or release an opioid antagonist
70
Immediate release is for
breakthrough pain, to discourage abuse and buildup of tolerance
71
Opioid BBW
Children, hypoventilation, not to be split chewed or dissolved, don't abruptly stop treatment, baby can be effected, somnolence
72
Opioid Contraindications
Respiratory depression, bronchial asthma, convulsive disorders, addiction prone, treatment of diarrhea
73
Opioid pregnancy category
C (because of withdrawal syndrome in babies)
74
NAL
Narcotic Antagonists
75
Naloxone
should be made available

P1-f FoundPharm (5 decks)

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