E1 - Corticosteroids

Question 1

corticosteroids are derived from

Answer 1

synthetic versions of endogenous hormones from the adrenal cortex portion of the two adrenal glands

Question 2

corticosteroids used for

Answer 2

anti-inflammatory effects

Question 3

hormone secreted by anterior pituitary

Answer 3

adrenocorticotropic hormone (ACTH) also referred to as corticotropin

Question 4

ACTH stimulates the

Answer 4

adrenal gland to release corticosteroids

Question 5

2 classes of adrenocorticosteroids

Answer 5

glucocorticoids and mineralocorticoids

Question 6

glucocorticoids

Answer 6

cortisol and cortisone; effects glucose metabolism, protein and lipid metabolism, effecting inflammation

Question 7

mineralocorticoids

Answer 7

aldosterone; water and electrolyte balance and metabolism, retention of Na and excretion of K+

Question 8

structure of CS

Answer 8

four ring steroid structure (functional groups attached to pentanu

Question 9

uses of CS

Answer 9

HRT, Anti-inflammatory and immunosuppressive effects, hormonal regulation of the expression of genes, anti-allergic

Question 10

immunosuppressive effects

Answer 10

suppress response, especially involving lymphocytes

Question 11

SLE (lupus)

Answer 11

chronic autoimmune and inflammatory disease, especially in skin and organs, can be treated by adjunctive therapy and CS

Question 12

neoplastic uses of CS

Answer 12

used primarily in advanced cancers

Question 13

metabolic effects of CS

Answer 13

increased blood glucose and insulin secretion, muscle protein catabolism, lipolysis and lipogenesis

Question 14

anabolic steroids

Answer 14

“olone”s involved in the synthesis and buildup of protein

Question 15

steroids other than “olones”

Answer 15

are catabolic in nature

Question 16

adverse long term

Answer 16

osteoporosis, muscular atrophy, thinning of skin, adrenal suppression and insufficiency

Question 17

contraindicated with

Answer 17

systemic fungal infections and administration of live vaccines

Question 18

addisons disease

Answer 18

primary adrenocortical insufficiency; causes lethargy, weight loss, hyperpigmentation, electrolyte abnormalities, hypotension

Question 19

cushings syndrome

Answer 19

adrenocorticoid excess; increased blood pressure, weight gain, fat redistribution, hirsutism, hyperglycemia

Question 20

dosing of corticosteroids

Answer 20

initial doses vary, titration may be needed,

Question 21

NTI drugs

Answer 21

narrow therapeutic index (CS are not NTI drugs)

Question 22

getting off CS

Answer 22

tapering is used in long term treatment, so avoid secondary Addisons syndrome

Question 23

Safety of CS

Answer 23

safe, even at higher doses, up to one week

Question 24

cortisone and hydrocortisone

Answer 24

short acting steroids

Question 25

hydrocortisone

Answer 25

mostly topical, pruritis (itching), fungal, eczema

Question 26

prednisone is a ____ of prednisolone

Answer 26

prodrug

Question 27

methylprednisolone brand name

Answer 27

medrol, depo-medrol, solu-medrol

Question 28

betamethasone

Answer 28

long acting CS, given IM or topically

Question 29

triamcinolone

Answer 29

injectable suspension (IM), intranasal

Question 30

Beclomethasone

Answer 30

(QVAR) - asthma

Question 31

Budesonide

Answer 31

Symbicort, Pulmicort, Rhinocort

Question 32

Fluticasone

Answer 32

Flovent, Arnuity, Flovent, Flonase

Question 33

Mometasone

Answer 33

Nasonex, Asmanex

Question 34

Fludrocortisone Acetate 0.1mg

Answer 34

potent mineralocorticoid (addisons disease: resorption of sodium and promote fluid retention to support BP

Question 35

Counseling for opthalimic preparations (excluding solutions and ointments

Answer 35

shake well

Question 36

PredForte

Answer 36

Opthalmic given as prednisolon (the active form)