EXAM 1 Flashcards
Which channels account for the “plateau” observed in the ventricular (fast) cardiac muscle action potential?
voltage-gated slow (L-type) Ca+2 channels,
Which channels account for action potential depolarization in slow, autorhythmic cardiac fibers?
voltage-gated slow (L-type) Ca+2 channels,
An increase in ventricular contractile force due to Frank-Starling mechanisms would be termed an increase
preload
The adrenergic receptors that directly mediate increases in heart rate and contractility are classified as:
beta-1; β1,
Parasympathetic nervous system effects on heart rate are mediated by which SA node receptors?
muscarinic
What is the carotid sinus baroreceptor action potential (AP) response to an acute increase in blood pressure?
AP frequency increases
Even though vessel radius decreases, the cross-sectional area of a capillary bed increases, causing blood flow velocity to:
decrease
What is the most important force driving filtration at the arterial end of a capillary?
Blood hydrostatic pressure
The most important determinant of “long-term” regulation of blood pressure would be:
blood volume
During strenuous exercise, which parameter would change the most?
muscle blood flow
Which component is the most important contributor to blood viscosity?
albumin
Which state would not be associated with anemia?
polycythemia
An elevated band cell count would indicate overproduction of which cell type?
neutrophils
What is the primary function of thrombin?
converts fibrinogen to fibrin
The first clotting factor the intrinsic and extrinsic pathways have in common is:
factor X
What does not prevent the spontaneous formation of a clot
the presence of tissue thromboplasin`
An individual has type B, Rh- positive blood. The individual has ____ antigens and can produce anti-________ antibodies
B and D; A
What is the largest leukocyte that contains small cytoplasmic granules and typically a kidney- or horseshoe shaped nucleus
Monocyte
A normal hematocrit is _______ of total blood volume.
37% to 52%
What are the least abundant of the formed elements?
Basophils
The universal donor of RBC’s, but not necessarily plasma, is blood type_______
O, Rh- negative
What would happen if all of the hemoglobin contained within the RBC’s became free in the plasma
it would increase blood osmolarity
A person with type AB blood has _____ RBC antigens
A and B
a patient is diagnosed with Leukocytosis if they have more than ________ WBCs/ul
10,000
The cessation of bleeding is specifically called
hemostasis
Where does myeloid hemopoiesis take place in adults
Red bone marrow
Which cells aid the bodys defense processes by secreting histamine anf heparin?
Basophils
Most strokes and heart attacks are caused by the abnormal clotting of blood in an ubroken vessel. Moreover, a pieceo of the _____ may break loose and being to travel in the bloodstream as an ______.
thrombus; embolus
What is not normally found in plasma
Glycogen
The main reason why an individual with Type AB, Rh- negative blood cannot donate blood to an individual with Type A, Rh-positive blood is because ______
anti- B antibodies in the recipent will agglutinate RBCs of the donor
What would not decrease the blood colloid osmotic pressure?
a diet predominatly based on meat
What is not a function of blood
produces plasma hormones
the number of _____ typically increases in response to bacterical infections.
neutrophils
a defiency of _____ can cause permicious anemia
vitamin B12
What are the most abundant agranuocytes
Lymphocytes
Blood clots in the limbs put a patient most at risk for ______
pulmonary embolism
Which of the following might be injected into apatient who is prone to forming blood clots and therefore at risk of a heart attack or stroke
Heparin
What is not true of a patient with anemia
their blood viscosity is increased
What is the most abundatn protein in plasma
Albunin
Leukopoiesis beigns with the differentation of
pluripotent stem cells
Why are pregnant Rh- women given an injection of Rh immune globulin?
Antibodies in the injection bind fetal RBC antigens so they cannot stimulate her immune systen to produce anti- D antibodies.
During coagulation, which of the following is found in the extrinsic mechanism only?
Thromboplastin
What is the function of thromboplastin in hemostasis
it initiates the exstrintic pathway of coagulation
The ABO blood group is determined by _____ in the plasma membrace of RBC’S
glycolipids
A patient is suffering from ketoacidosis caused by an unregulated high protein diet. Which functions of the blood has been compromised ?
stabilizing the bodys pH
Some lymphocytes can survive as longas
decades
What is not true regarding sickle-cell disease?
it is a cause of malaria
Erythrocytes transport oxygen and ______
transport some carbon dioxide
When a clot is no longer needed, fibrin is dissolved by ______
plasmin
What is not secreted by platelets?
thrombopoletin
Where in the body are hemopoietic stem cells found?
red bone marrow
Serum is essentially identical to plasma except for the absence of _________
fibrinogen
What is the final product of the breakdown of the organic nonprotein moiety of hemoglobin?
Bilirubin
The strutural framework of blood clot is fromed by ________
a fibrin polymer
Platelets release ______ a chemical vasoconstrictor that contributes to the vascular spasm
serotonin
Most oxygen is transported in the blood bound to ______
heme groups in hemoglobin
Which of the following is not contained in the buffy coat
Erythrocytes
Which of the following proteins is not normally found in plasma
Hemoglobin