Exam 1 Flashcards
Echinacea (purple coneflower root)
Pharmacologic: Activation of cell mediated immunity. Periop Concerns: allergic reaction, decreased immunosuppressant effects, poss. immunosuppression with longterm use
Ephedra (mahuang)
Pharmacologic: Directly/indirectly Increases heart rate and blood pressure Periop Concerns: Ischemia, Arhythmias, depleted catecholamines, interacts with MAOI D/C: 24 hours prior
Garlic (ajo)
Pharmacodynamics: Inhibits platelet aggregation, increases fibrinolysis, antihypertensive activity D/C: 7 days prior
Ginger
Pharmacodynamics: Anti-emetic, antiplatelet aggregation
Ginkgo (duck-foot tree, silver apricot)
Pharmacodynamics: Inhibits platelet activating factor D/C: 36 hours prior
Ginseng
Pharmacodynamics: Lowers blood sugar, inhibits platelet aggregation, increased PT/PTT in animals Periop Concerns: May decrease anticoagulant effect of warfarin D/C: 7 days prior
Green tea
Pharmacodynamics: Inhibits platelet aggregation and thromboxane A2 formation Periop Concerns: May decrease anticoagulant effect of warfarin D/C: 7 days prior
Kava (awa, intoxicating pepper, kawa)
Pharmacodynamics: sedation and anxiolysis Periop Concerns: May increase anesthetic effect, long term use increases anesthetic requirement D/C: 24 hours prior
Saw palmetto (dwarf palm)
Pharmacodynamics: Inhibits 5 alpha reductase (responsible for turning testosterone into DHT) and cyclooxygenase
St. John’s Wart (goat weed, hardhat, amber)
Pharmacodynamics: Inhibits neurotransmitter reuptake, MAO inhibition unlikely Periop Concerns: Decrease serum dig levels, delays emergence, induction CP450 D/C: 5 Days
Valerian (vandal root, all heart, garden heliotrope)
Pharmacodynamics: Sedation Periop Concerns: Increase anesthetic effect, acute benzo-like withdrawal, long term use increases anesthetic requirements
Anesthesia considerations for ACE inhibitors (-pril) Intraop concerns, management and D/C issues
Intraop Concerns: Intolerance of hypovolemia, hypotension Management: Optimize hydration and moderate doses of vasporessors D/C issues: Brief interruption tolerated well, may improve regional blood flow and oxygen delivery and preserve renal function, HOLD am dose day of surgery
Anesthesia considerations for beta blockers (-lol) Intraop concerns, management and D/C issues
Intraop Concerns: D/C may increase cardiovascular morbidity and develop of withdrawal symptoms Management: Hydration D/C issues: Should be continued on day of surgery
Anesthesia considerations for Calcium channel blockers Intraop concerns, management and D/C issues
Intraop concerns: Decrease. SVR and BP d/t peripheral vasodilation; Neg. into and chronotropic effects Management: Hydration and phenylephrine as needed to maintain atrial pressure D/C issues: Caution in patients with left ventricular dysfunction shown by EF <40%
Anesthesia considerations for diuretics Intraop concerns, management and D/C issues
Intraop concerns: hypokalemia and hypovolemia Management: Preop potassium levels, hydration D/C issues: Pts rarely show issues with holding morning dose, might be desirable to continue if part of tx for chronic renal failure
Anesthesia considerations for antiarrythmics Intraop concerns, management and D/C issues
Intraop concerns: Cardiac depression, prolonged neuromuscular blockade Management: Serum drug levels as needed, if on amio may need vasopressor, inotropes and pacemaker capability D/C issues: Rarely recommended to stop meds, withhold concurrent medications such as ACE-i
Anesthesia considerations for NSAIDS and anti platelet drugs Intraop concerns and D/C issues
Intraop concerns: impaired plt function, altered renal function, GI bleed D/C issues: Antiplatlet drugs such as aspirin, clopidogrel, ticlodipine should be d/c 7-10 days prior, NSAIDS can be continued the day of unless risk of bleeding is high
Anesthesia considerations for anticoagulants (heparin, coumadin, LMWH) Intraop concerns, management and D/C issues
Intraop concerns: Increased hemorrhage Management: Reverse heparin w/ protamine, revers coumadin with vitamin k or FFP D/C issues: Heparin IV 6 hours prior and check PTT, Coumadin 3-5 days prior, 5 if INR <1.5 needed, LMWH 12 hours prior to surgery
Anesthesia considerations for fibrinolytic (streptokinase, TPA, urokinase) Intraop concerns, management and D/C issues
Intraop concerns: Hemorrhage Management: Antifibrinolytics (aprotinin) may be indicated D/C issues: usually not an option
Anesthesia considerations for oral hypoglycemic agents Intraop concerns, management and D/C issues
Intraop concerns: Hyperglycemia/hypoglycemia Management: Avoid dehydration and monitor serum glucose D/C issues: Withhold oral agents the day of surgery
Anesthesia considerations for MOAI’s Intraop concerns, management and D/C issues
Intraop concerns: Hypertension secondary to norepinephrine release; meperidine causes excitatory state or depressive phenomena secondary to opioids Management: Avoid triggering agents such as meperidine, pentazocine, dextromethorphan and indirect sympathomimetics D/C issues: Irreversible MAOI’s 2 weeks prior w/ high risk of serious psychiatric consequences, reversible can be continued up to the day of surgery
Anesthesia considerations for TCA’s Intraop concerns, management and D/C issues
Intraop concerns: alpha blocking activity and potential to block norepinephrine reuptake potential for cardiac issues, lowers seizure threshold Management: norepinephrine should be considered the vasopressor of choice D/C issues: gradually over 2 weeks prior to surgery, obtain baseline ECG
Anesthesia considerations for Lithium Intraop concerns, management and D/C issues
Intraop concerns: Ventricular arryhthmias, atropine-resistant sinus brady, dehydration increases lithium levels Management: Hydration D/C issues: 72 hours prior to surgery
Neuraxial Anesthesia guidelines for LMWH (exonaparin, dalteparin, tinzaparin) When to hold before procedure/catheter removal, when to restart med after procedure/catheter removal, additional info and half-life
Before procedure: 24 hours, check anti factor Xa in elderly/renal insufficient Restart after procedure: 24-72 hours Before catheter removal: Should be removed before intiation of LMWH Restart after catheter removal: 4 hours prior to first post dose and at least 24 hours post neuraxial procedure Additional: Wait >24 hours after bloody tap to restart Half-life: 4-7 hours
Neuraxial Anesthesia guidelines for Fondaparinux (Arixtra) When to hold before procedure/catheter removal, when to restart med after procedure/catheter removal, additional info and half-life
Before procedure: Regional - no recommendation, Pain - 4 days (5 half lives) Avoid restarting the medication while catheter is in place Restart after catheter removal: 6 hours Additional info: Longer hold time in patients with renal impairment (CrCl <50-30 ml/min); Contraindicated in CrCl <30 or child-pugh C hepatic failure Half-life: 17-21 hours
Neuraxial Anesthesia guidelines for Factor Xa-inhibtors (edoxaban, rivaroxaban, apixaban) When to hold before procedure/catheter removal, when to restart med after procedure/catheter removal, additional info and half-life
Before procedure: 72 hours Restart after procedure: At least 6 hours, avoid while catheter is in place Before cather removal: 20-30 hours depending on med Restart after catheter removal: 6 hours, longer if bloody tap Additional info: same as fondaparinux Half-life: rivaroxaban: 5-9 hours, apixaban: 6-12 hours, edoxaban: 10-14 hours
Neuraxial Anesthesia Guidelines for argatroban, a direct thrombin inhibitor When to hold before procedure/catheter removal, when to restart med after procedure/catheter removal, additional info and half-life
Before procedure: avoid Restart after procedure: Avoid while catheter is in place Before catheter removal: 34-36 hours Restart after catheter removal: 2 hours Additional info: 1/2 life in hepatic impairment is 181 min Half-life: 40-50 minutes
Neuraxial Anesthesia Guidelines for bivalirudin (angiomax), a direct thrombin inhibitor When to hold before procedure/catheter removal, when to restart med after procedure/catheter removal, additional info and half-life
Before procedure: avoid Restart after procedure: while catheter is in place Before catheter removal: 34-36 hours Restart after catheter removal: 2 hours Additional info: 1/2 life with CrCL <30ml/min is 57min Half-life: 25 min
Neuraxial Anesthesia guidelines for dabigatran (Pradaxa), a direct thrombin inhibitor When to hold before procedure/catheter removal, when to restart med after procedure/catheter removal, additional info and half-life
Before procedure: 5 days Restart after procedure: 6 hours unless catheter is in place then avoid Before catheter removal: 34-36 hours Restart after catheter removal: 6 hours, 24 hours post traumatic puncture Additional info: consider longer hold times in renal impairment Half-life: 8-17 hours
Neuraxial guidelines for clopidogrel (plavix) When to hold before procedure/catheter removal, when to restart med after procedure/catheter removal and half-life
Before procedure: 5-7 days Restart after procedure: restart immediately if no loading dose, 6 hours if LD Before catheter removal: 24 hours postop Restart after catheter removal: restart immediately, 6 hours if loading dose Half life: 6 hours
Neuraxial guidelines for cilostazol (pletal) When to hold before procedure/catheter removal, when to restart med after procedure/catheter removal, additional info and half-life
Before procedure: 48 hours Restart after procedure: 6 hours unless catheter still in then avoid Before catheter removal: avoid restarting Restart after catheter removal: 6 hours Additional info: consider extending time prior to catheter placement if renal impairment Half-life: 11-13 hours
Neuraxial Anesthesia guidelines for Diprydamole/ASA (Aggrenox), an anti platelet drug When to hold before procedure/catheter removal, when to restart med after procedure/catheter removal and half-life
Before procedure: 24 hours Restart after procedure: 6 hours unless catheter in place Before catheter removal: avoid Restart after catheter removal: 24 hours post, immediately post neuraxial procedure, 6 hours if loading dose Half-life: 10-12 hours
Neuraxial Anesthesia guidelines for prasugrel (effient), an anti platelet drug When to hold before procedure/catheter removal, when to restart med after procedure/catheter removal and half-life
Before procedure: 7-10 days Restart after procedure: Immediately if no loading dose, avoid if catheter in place Before catheter removal: avoid Restart after catheter removal: same as after procedure Half-life: 2-15 hours
Neuraxial Anesthesia guidelines for ticagrelor (brilinta), an anti platelet drug When to hold before procedure/catheter removal, when to restart med after procedure/catheter removal and half-life
Before procedure: 5-7 days Restart after procedure: immediately if no loading dose, avoid if catheter in place Before catheter removal: Avoid Restart after catheter removal: Same as after procedure Half-life: 7 hours
Neuraxial Anesthesia guidelines for ticlodipine (ticlid), an anti platelet drug When to hold before procedure/catheter removal, when to restart med after procedure/catheter removal and half-life
Before procedure: 10 days Restart after procedure: Avoid while catheter in place Before catheter removal: 6 hours Restart after catheter removal: 24 hours post, immediately post neuraxial, 6 hours if loading dose Half-life: 13 hours
Neuraxial Anesthesia guidelines for cangrelor, an anti platelet drug When to hold before procedure/catheter removal, when to restart med after procedure/catheter removal and half-life
Before procedure: 3 hours Restart after procedure: 8 hours Before catheter removal: Avoid Restart after catheter removal: 8 hours Half-life: 3-6 minutes
Neuraxial Anesthesia guidelines for fibrinolytics (streptokinase, alteplase, tenecteplase, reteplase) When to hold before procedure/catheter removal, when to restart med after procedure/catheter removal and additional info
Before procedure: 10 days, 48 hours + normal clotting studies including fibrinogen Avoid restarting the medication while catheter in place, if needed then neuro checks Q2 hours Check fibrinogen level before restarting after catheter removal (TPA has the longest half life at 24-46 hours)
Neuraxial Anesthesia Guidelines for abciximab (reopro), a GP 2b/3a inhibitor When to hold before procedure/catheter removal, when to restart med after procedure/catheter removal, additional info and half-life
Before procedure: 24-48 hours Avoid restarting the medication while catheter is in place Restarting medication after catheter removal is contraindicated for 4 weeks post op Additional info: receptor bound remain for up to 2 weeks Half-life: 30 minutes
Neuraxial Anesthesia Guidelines for eptifibatide (integrellin), a GP 2b/3a inhibitor When to hold before procedure/catheter removal, when to restart med after procedure/catheter removal and half-life
Before procedure 4-8 hours Avoid restarting medication while catheter is in place Restarting medication after catheter removal is contraindicated for 4 weeks post op Half-life: 2.5 hours
Neuraxial Anesthesia guidelines for tirofiban (aggrasta), a GP 2b/3a inhibitor When to hold before procedure/catheter removal, when to restart med after procedure/catheter removal and half-life
Before procedure: 4-8 hours Avoid restarting medication while catheter is in place Restarting medication after catheter removal is contraindicated for 4 weeks post op Half-life: 2 hours
ASA 1
A normal healthy patient Healthy, non-smoking, no/minimal alcohol use
ASA II
mild systemic disease without substantial functional limitations: current smoker, social alcohol drinker, preggo, obesity, controlled HTN/DM, mild lung disease
ASA III
severe systemic disease with 1+ of: poorly controlled DM/HTN/COPD/Morbid Obesity, active hepatitis, ETOH abuse/dependency, pacemaker, reduced EF, ESRD (regular HD), premie or age <60 weeks >3months of: MI, CVA, TIA, CAD/stents
ASA IV
severe systemic disease w/constant threat to life: <3months: MI, CVA, TIA, CAD/stents ongoing cardiac ischemia or severe valve dysfunction severely reduced EF; sepsis/DIC/ARDS/ESRD (no regular HD)
ASA V
moribund patient who is not expected to survive without operation: ruptured aneurysm, massive trauma, intracranial bleed w/mass effect, ischemic bowel, MODS or significant cardiac pathology.
ASA VI
declared brain dead patient whose organs will be removed for donor purposes.
Pack-Year formula
of cigs / 20 x years smoked = PPY (there are 20 ciggies in a pack)
NMBD allergen tier list
Rocuronium > Succinylcholine (anectine) > Atracurium > Vecuronium
Allergies (most common to least)
Muscle relaxants > Latex > Antibiotics (PCN) > Local Anesthetics (esters > amides)
Oxygen formula constants
Oxygen carrying capacity: 1 g Hgb = 1.34 ml O2 Solubility coefficient of O2 = 0.003 ml O2/100ml
Oxygen Saturation formula
(Oxygen combined with Hgb / Oxygen carrying capacity) x 100 1. Find Plasma O2 (PaO2 x solubility coE of O2) 2. Subtract plasma O2 from total O2 content (given) 3. Find O2 carrying capacity: Multiply Hgb (given) x 1.34 4. Divide values “2”/”3” and x100
BMI formula
Weight (kg) / Height (m^2) Remember to convert! 1 kg = 2.2 lb 1 cm = 2.54 in.
What are 3 key points associated with brachytherapy
- Seed implantation for prostate cancer 2. Patient will be in the lithotomy position 3. If seeds not successful, patient will need a prostatectomy
In what area would we place invasive lines?
Preop setting
2 examples of things we look for when reviewing Anesthesia Records?
- Malignant Hyperthermia 2. Laryngospasm
Who should we ask if there is a question about what type or where the surgery is occurring?
The surgeon
Other name for succinylcholine?
Anectin
Other name for bupivicaine?
Marcaine
Major risk associated with Diabetes Mellitus that is relevant to anesthesia?
Aspiration due to slower motility presents an aspiration risk during induction and extubation
What are 3 considerations for patients that have asthma?
- Do they use an inhaler and what is it? 2. When was the last time they used an inhaler? 3. Should we order an inhaler to be used prior to surgery?
What should we be aware of with COPD patients? (2 things related to airway)
- Laryngospasm 2. Post-op respiratory depression
What is Pickwickian’s Syndrome?
Hypoventilation associated with obesity
What is a key sign of spinal headache?
Headache that gets worse with sitting up
Treatment for spinal headache?
Caffeine, laying down, or blood patch
5 Major anesthesia complications
- Spinal headache 2. Malignant Hyperthermia 3. Difficulty waking uo 4. Difficult airway 5. Awareness
When considering a patients blood pressure, what should we look at?
Check patients health history to get a good idea of their baseline blood pressure as we want it to be 10-15% from that baseline during surgery
What reading is classified as uncontrolled hypertension?
Two or more readings greater than 140
If your patient shows with a SBP >200 or DBP > 115, what is this indicative of and what should be done in regards to the procedure?
This is indicative of malignant hypertension and the procedure should be delayed until a cardiac consult is obtained
4 diseases associated with unstable cardiac disease?
- Aortic stenosis 2. New onset Afib 3. New onset SVT 4. Congestive Heart Failure
What would a murmur indicate?
Possible congestive heart failure or valve prolapse, delaying surgery
What would the presence of bruits over the carotid arteries indicate?
High risk for stroke, consider delaying surgery
Risk factors associated with OSA? (4)
- Snoring (Morning headache that goes away soon after waking) 2. Daytime sleepiness 3. Hypertension 4. Obesity
Patients mom states that her infant has an upper respiratory tract infection, but needs their scheduled procedure done today as she cannot take off work again for awhile, what is your action as an anesthesia provider?
Delay the surgery and explain to the mom that they patient has a hyperactive airway and at high risk for laryngospasm
What is alcohols effect on albumin?
Alcohol lowers albumin levels, therefore allowing more free drug available in the system for protein bound drugs
What is metabolic syndrome associated with?
Diabetes Mellitus Type 2
What vasopressors do we utilize for renal patients on dialysis who may be hypovolemic?
Neo and ephedrine
What is a major issue with patient who have liver or gastric disorders?
They tend to bleed more
What are Hgb triggers?
Hgb triggers are numbers that we begin to worry about, but we look at the patient to see how they are doing (Oxygen supply depends on the amount of blood available)
When placing an NGT on your patient you get blood content back upon aspiration, what is a possible cause for this?
You hit a hiatal hernia
What is the major intra-op concern when a patient has been taking ACE-i?
Hypotension with or without bradycardia, have your vasopressors and hydration available
What beta blockers do we usually give intraoperatively?
metoprolol or esmolol
What would be considered massive bleeding?
1-2 liters of blood loss
What does ERAS stand for?
Enhanced recovery after surgery
What is the goal for ERAS?
To go home quickly
Which patients do we want to avoid use of NSAIDS for?
Acute or chronic kidney disease
With use of NSAIDs, which surgery presents a high risk of anastomotic leak?
Cholorectal surgery
What is are the other names for vitamin k?
phytonadione (aqua-mephyton)
What does chiroprecipitate replace?
Factor 1
What do we worry about intraoperatively with insulin users?
Hypoglycemia and infection
Can we give contrast media to patients taking metformin?
Yes, new research shows that it is not contraindicated
What is the hypertension caused by with MAOI’s?
Norepinephrine release
Why does surgery cause the release of stress hormones?
Sympathetic nervous system activity increases
What are the 3 stress hormones released during surgery?
- Glucagon 2. Epinephrine 3. Steroids (Cholesterol based)
Example of glucocorticosterioids
cortisols
Example of mineralocorticoids
aldosterone
Example of Androgens
testosterone
When does HPA (hypothalamic pituitary axis) suppression occur?
Exogenous steroid use
What does the adrenal cortex release?
Steroids
What does the adrenal medulla release?
Epinephrine
Why is it relevant that HPA is suppressed with exogenous steroid use?
No cortisol will be released by the body, meaning the hypotension will not resolve until steroids are administered
2 Risk factors for HPA suppression
- 2 weeks of corticosteroids used within 3 months, doesn’t matter what form of steroid 2. 20mg/day prednisone
What is the problem with herbal medications?
They are not regulated by the FDA
When should herbal medications be discontinued if there is no pharmacokinetic data?
1 week prior to surgery
What should you do before giving versed to a patient?
Make sure family members are gone
List the most common allergic reactions from most common to least common
- Muscle relaxants 2. Latex 3. Antibioitics 4. Local Anesthetics (Esters being more common than Amides)
What is one of the first questions we ask a patient during an emergency?
What allergies do they have
What would be an example of an adverse side effect vs a medication reaction?
Adverse SE = Nausea and vomiting Reaction = Airway closure
Describe anaphylactic reactions
Involve multi organ system failure, immune mediated (IgE), mediators released from mast cells and basophils, LIFE THREATENING
Describe anaphylactoid reactions
non-IgE mediated, mediators released from mast cells and basophils and direct complement activation, LIFE THREATENING
List the allergic reactions of common NMBD in order from most common to least common
- Roc 2. Such 3. Atracarium 4. Vecuronium
What causes NMBD to have a high affinity for IgE receptors?
Quartenary Ammonium Ions have the high affinity for IgE receptors
What is hypotension secondary to in an anaphylactic reaction?
Histamine, protease, proteoglycans and platelet activating factors; these are all inflammatory markers
What is pulmonary vasodilation and bronchoconstriction secondary to in an anaphylactic reaction?
Potent inflammatory leukotrienes (LTC) and prostaglandins (PGD); These cause increased reactivity of the respiratory system
What does pancuronium cause that is good for some cardiac patients?
Tachycardia to help with cardiac output, this med lasts a long time
What do LTC and PGD cause?
Bronchial constriction and increased vascular permeability (Can give montelukast to prevent action of these and open up airways)
What does histamine cause?
Vasodilation, erythema, edema, arterial hypotension, GI constriction, tachycardia, pruritus, urticaria, angioedema
If you suspect a patient is having an allergic reaction to NMBD during a procedure, what action can you take to maintain muscle relaxation?
Utilize inhalation anesthetics
What type of chest redness would you look for to determine if a patient who is under general anesthesia is having an allergic reaction?
Non-blanchable redness, most commonly starts on the chest area
Describe latex-mediated reactions
- Irritant contact dermatitis 2. Type IV cell-mediated reactions 3. Type I IgE mediated hypersensitivity
What type of food allergies would indicate a true latex allergy?
Bananas, kiwi and tropical fruits
What patient population would be at high risk for developing a latex allergy?
Kids with spina biphida or those with long term urologic issues that exposed them to multiple foley catheter insertions
What is the correct way to handle rubber stoppers for medications vials with patients who have latex allergies?
Follow hospital policy
What inhalation agent can we use to treat symptoms associated with IV contrast allergies?
Mucomyst
What is NORA?
Non-OR-Anesthesia
What would you see that would cause you to suspect contrast induced nephropathy (CIN)?
Increased in serum creatinine of 0.5mg/dL or 25% increase from baseline
What is the most common antibiotic allergy?
Penicillin (Small risk of cross sensitivity, <2%, to cephalosporin
What is the mediator for ester allergic reactions?
para-aminobenzoic acid (PABA)
What is the mediator for amide allergic reactions?
methylparaben (chemically similar to PABA)
How many “i” are found in the name of ester local anesthetics?
one
How many “i” are found in the name of amide local anesthetics?
two
What are 6 key signs of anaphylaxis under General Endotrachial Anesthesia?
- Urticaria 2. Bronchospasm 3. Upper airway edema 4. Vasodilation 5. Erythema 6. Peripheral Edema
What would you observe that would make you suspect a patient is having bronchospasms while under GETA?
high pressures on the vent
What would you observe that would make you suspect a patient is having upper airway edema while under GETA?
swelling in the oral cavity
What type of feedback mechanism do baroreceptors utilize to regulate body functions?
negative feedback
What effects do you see from nicotine use?
Cardiovascular effects
What are the effects on the cardiovascular system seen from nicotine use?
- Adrenal Stimulation 2. Carotid body and aortic sinus resetting of baroreceptors, mimicking increased sympathetic tone
What is the effect of adrenal stimulation with nicotine use?
Intraoperative tachycardia and post-op delayed wound healing
What is the definition of hypoxemia?
Low concentration of oxygen in the blood
Why is carbon monoxide dangerous to oxygenation?
Carbon monoxide has a 200-250x greater affinity for Hgb than oxygen
What does carbon monoxide lead to in smokers?
Reduction in oxygen transportation and an increased risk of hypoxemia in smokers Reduces availability of O2 binding sites and carrying capacity
What causes the increased risk of infection in smokers?
increased sympathetic tone from nicotine and have decreased macrophage function (fight infections)
Interventions that can be utilized in smokers for respiratory or airway complications?
Patient will have a hyperactive airway, we can give lidocaine, make sure patient is fully sedated prior to intubation, and utilize gases during induction to dilate bronchi
What is the worry when a patient has a severe cough and what can we do to prevent it?
Laryngospasm that can be prevented by utilizing an oral airway, lidocaine or propofol
By what percent can the carboxyhgb in smokers be increased from the normal 1-1.5%?
Can be as high as 5-15%
What type of shift does carbon monoxide cause on the oxyhemoglobin dissociation curve?
left shift due to a reduction in 2,3 DPG from inhibition of glycolysis in erythrocytes
4 factors that would cause a left shift on the oxyhemoglobin dissociation curve?
- Decreased PCO2 2. Decrease temp 3. Decrease 2,3 DPH 4. Increased pH
What does a left shift on the oxyhemoglobin dissociation curve represent?
Hgb does not want to let go of oxygen, it is left-locked
4 factors that would cause a right shift on the oxyhemoglobin dissociation curve?
- Increased PCO2 2. Increased temp 3. Increased 2,3 DPG 4. Decreased pH
What does a right shift on the oxyhemoglobin dissociation curve represent?
Hgb wants to get rid of oxygen to the tissues; Right released
What type of shift would an increase in P50 cause on the oxyhemoglobin dissociation curve?
Right
What type of shift would methemoglobin cause on the oxyhemoglobin dissociation curve?
Left
What type of shift would fetal hemoglobin cause on the oxyhemoglobin dissociation curve?
Left
What type of shift would maternal hemoglobin cause on the oxyhemoglobin dissociation curve?
Right
What type of shift would sickle cell cause on the oxyhemoglobin dissociation curve?
Right
What is 2,3 DPG responsible for?
RBC production
When do you start seeing a reduction in HR, BP and circulating catecholamines after smoking cessation?
12-24 hours
What does not improve post 24 hours of smoking cessation?
pulmonary function
When do carboxyhemoglobin and cyanide levels drop after smoking cessation?
24 hours
After smoking cessation, what does lower nicotine levels in the body assist in improving?
improves vasodilation and toxins
What test can be incorporated to asses alcohol history?
CAGE (cut, annoyed, guilty, eye) 2 positive responses mean patient is at high risk for alcoholism
What are 4 anesthesia implication for chronic alcohol users?
- Aspiration d/t slowed gastric motility 2. Increased MAC requirements 3. Increase depressant effects of opioids and benzos 4. Resistance to nondepolarizers (roc, vec, cis)
What does 1 MAC mean?
50% of patients won’t move and 50% of patients will move
2 Anesthesia implications for acute alcohol users?
- Lower MAC needed b/c alcohol is already causing the relaxant effects 2. Synergy with other depressant drugs such as opioids, which effect would be doubled
What are the 4 reasons why aspiration risk is higher in chronic alcohol users?
- Gastric motility slowed 2. Gastroesphageal sphincter tone is diminished 3. Increased intraabdominal pressure 4. Elevated gastric acid levels
What anesthesia considerations should we take when we have an elderly patient who is a chronic alcohol user?
Want to either skip giving benzos or decrease the dose given