EXAM 1 Flashcards
Where does the esophagus enter the diaphragm?
T10
Where does the Esophagus end?
At cardia of the stomach, T11
The esophagus passes close to ______
The trachea and left side of heart
Can problems with the esophagus cause problems with the heart?
YES - Eating something too hot can sometimes feel like pain close to or in the heart or throat
The esophagus is surrounded at the top and bottom by 2 muscular rings, what are they?
The upper esophageal sphincter and lower
What lines the esophagus ?
Has a nonkeratinized stratified squamous epithelial lining which protects the esophagus from trauma
What does the submucosa of the esophagus secrete?
Mucus from mucous glands which aids the passage of food down the esophagus
What is the lumen of the esophagus surrounded by?
Layers of muscle
The lumen of the esophagus has muscles, what types of muscles are in these?
- Voluntary in TOP 1/3rd (striated) - Involuntary in the BOTTOM 1/3rd (smooth muscle) - The MIDDLE 1/3rd containing a mixture of BOTH
What shape is the stomach?
J-Shaped with 2 openings 1). Esophageal 2). Duodenal
What are the 4 major regions of the stomach?
Fundus, Cardia, Stomach Body, Pylorus
What does the fundus collect?
Digestive gases
What does the body of the stomach secrete?
Pepsinogen and Hydrochloric acid
The pylorus is responsible for _____
Production of mucus, hormone gastrin, and pepsinogen secretion
The glandular tissue within the stomach mucosa account for secretion of various substances, what are they?
1). Parietal cells 2). Chief (zymogen) cells 3). Enteroendocrine cells (G cells)
What do parietal cells secrete?
Hydrochloric acid and intrinsic factor
What do chief (zymogen) cells secrete?
Pepsinogen
What do enteroendocrine cells (G-cells) secrete?
Hormone gastrin
The stomach wall contains 3 layers of involuntary smooth muscles which aid digestion by physically breaking up the food particles, what are they?
- Inner oblique layer 2. Circular layer 3. Outer longitudinal layer
What are the 5 major functions of the stomach?
- Preliminary digestion of protein with pepsin 2. Temporary food storage 3. Control of the rate at which food enters the duodenum 4. Acid secretion and antibacterial action 5. Fluidsation of stomach content
What are the 3 main sections of the small intestine?
- Duodenum 2. Jejunum 3. Ileum
The small intestine is the site where the most of _____ is carried out?
Chemical and mechanical digestion and where virtually all of the absorption of useful material is carried out
What is the wall of the small intestine lined with?
An absorptive type of mucosa, with certain modifications of each intestine
What does the wall of the small intestine have as far as muscles?
2 layers of smooth muscles, rhythmical contractions of which move products of digestion through the intestine (peristalsis)
The duodenum is the _____
FIRST of 3 parts of the intestine
What is the duodenum attached to?
The pylorus of the stomach
How long is the Duodenum?
25-30 cm long (12 fingers length), C - Shaped, and is located in upper abdomen
What lies in the C shape of the duodenum?
Pancreas
What are the 4 subdivisions of the duodenum?
- Superior part 2. Descending part 3. Horizontal part 4. Ascending part
Where does the superior part of the duodenum lie?
It lies intraperitoneally and is enlarged proximally (duodenal bulb)
The descending part and the rest of the duodenum is ______
Retroperitoneally
How do the pancreatic duct and common bile duct enter the descending duodenum through the _____
Major duodenal papilla - Hepatopancreatic ampulla (= ampulla of Vater)
The second part (descending) of the duodenum also can contain the _____
Minor duodenal papilla
What is the entrance for the accessory pancreatic duct?
The minor duodenal papilla (Papilla of Santorini)
Where does the Horizontal part of the duodenum pass?
In front of the inferior vena cava, abdominal aorta and the vertebral column, runs from right to left.
Where does the horizontal duodenum locate?
Retroperitoneally
How does the Ascending part of the Duodenum run?
Cranially along the left side of the vertebral column
What is special about the ascending part of the duodenum?
It joins with the jejunum
Where is the ascending part of the duodenum located?
Retroperitoneally
What are the main functions of the duodenum?
- neutralizing of acidic gastric content - further digestion - absorption of nutrients - regulation of the rate of gastric emptying
How does the duodenum neutralize acidic gastric content?
Brunner’s glands
Where are Brunner’s glands?
They are found in the duodenum only, locate in its submucosa.
What do Brunner’s glands secrete?
An alkaline mucus which neutralizes the chyme and protects the surface of the duodenum
What are the jejunum and ileum?
The greatly coiled parts of the small intestine, and together are about 4-6 meters long
What is special about the mucosa of the jejunum and ileum?
It is highly folded (folds are called plicae) and increase surface area for absorption
What are the characteristics of the Jejunum?
- Less complex arterial arcades - Longer Vasa Recta - More plicae circulares, thicker, more highly folded - No fat in mesentery
What are the characteristics of the Ileum?
- More complex arterial arcades - Shorter Vasa Recta - Less Plicae circulates, thinner less folded - Fat present in mesentery
In the jejunum and ileum, the epithelial surface of plicae is further folded to form ______
Villi
In the Jejunum and ileum the surface of each villus is covered by what?
MICROVILLI, to maximize surface area, and thus area available for absorption
The mucosa of the large intestine consists of 2 types of epithelial cells, what are they?
- Cells specializing for water absorption - Mucus producing goblet cells (they also locate in the small intestine)
The large intestine contains areas of lymphoid tissue called ______
Peyer’s patches
What do Peyer’s patches do?
They are also found in the distal part of ileum. - Peyer’s patches provide local immunological protection
What is the 2nd largest organ in the human body?
LIVER
During development, what does the liver do?
The liver size increases with increasing age, averaging 5 cm span at 5 years and attaining adult size by age 15
What does the liver’s size depends on?
Several factors: age, sex, body size
How much does a liver have to be to be considered abnormal?
2 - 3 cm larger or smaller
What are the 4 distinct lobes of the liver?
- Left - Right - Caudate - Quadrate
What is the Pancreas?
An endocrine organ that lies in the specifically the upper left abdomen
Where is the pancreas?
It is found behind the stomach, with the head of the pancreas surrounded by the duodenum
How long is the Pancreas?
About 15 cm (6in) long
What is the Pancreas divided into, anatomically?
- head - body - tail - neck
Where is the head of the Pancreas?
Rests within the con cavity of the duodenum
Where does the body of the Pancreas lie?
Lying behind base of stomach
Where does the tail of the Pancreas lie?
Which ends abutting the spleen
Where does the neck of the pancreas lie?
Lies between the body and the head, anterior to the superior mesentery artery and vein
What are the 2 ducts of the pancreas?
The main pancreatic duct, and the accessory pancreatic duct
What are the 2 roles of the Pancreas?
- Internal Hormonal Role (endocrine) 2. External Digestive Role (Exocrine)
What are the 4 main cells in the islets of the Pancreas (Internal Hormonal Role)?
- A (alpha) cells 2. B (beta) cells 3. Delta cells 4. Gamma cells
What do alpha cells of the pancreas secrete?
Glucagon (increases glucose in blood)
What do Beta cells of the pancreas secrete?
Insulin (decreases glucose in blood)
What do Delta cells secrete?
Somatostatin (regulates function of alpha and beta cells)
What do gamma cells secrete?
Pancreatic Polypeptide
What does the Pancreas secrete?
Pancreatic fluid that contains digestive enzymes
What do the external pancreas enzymes do?
Enzymes help to further break down the carbohydrates, proteins, and lipids in the chyme
How many pairs of salivary glands are there?
3, and they secrete up to ONE liter of saliva a day
What are the 3 Salivary glands?
- Parotid - Lie just below and in front of the ear near the jaw 2. Submandibular 3. Sublingual
What does Saliva contain?
- 98% water - mucus - salivary amylas - electrolytes - the proteins, mucin, lysozyme, and IgA
What does the stomach wall contain?
- Parietal cells - Chief cells - G cells
What do Parietal cells produce?
Hydrochloric acid and intrinsic factor
What do chief cells secrete?
Pepsinogen
What do G cells secrete ?
Gastrin
What is the flow of GI tract Stomach phys?
- Food 2. G-cells 3. Gastrin 4. Hydrochloric Acid 5. Pepsinogen (non active) 6. Pepsin (active) 7. Digestion of proteins
What are the substances the stomach absorbs?
Alcohol, meds, and water
What are the main things the small intestine digests?
Carbs, proteins, fats
What do Duodenal mucosal cells do in the small intestine?
Produce and release hormones secretin and cholecystokinin
What is secretin associated with?
Pancreatic juice
What is cholecystokinin associated with?
Bile from liver and gallbladder and pancreatic enzymes
What are the enzymes from the small intestine that digest protein?
- Chymotrypsin - Trypsin - Carboxypeptidase - Elastase (Breaks down short chain peptides to AA)
How does fat digestion in the small intestine occur?
Bile from the liver and gallbladder emulsifies fat, and then lipase (from pancreas) breaks down fat to fatty acids and glycerol
What is the sequence of fat digestion in the small intestine?
- Liver and Gallbladder 2. Bile 3. Fat 4. Emulsification 5. Pancreas 6. Lipase 7. Emulsified fat 8. Free fatty acids and glycerol
What is the process of carb digestion in small intestine?
Pancreatic amylase finishes the breaking down of carbs to simple sugars
What are the small intestine enzymes?
Maltese, Sucrase, Lactase
What does Maltese break down into?
2 glucose molecules
What does sucrase break down to?
glucose and fructose
What does lactase break down to?
Glucose and galactose
What are the substance absorbed in the Duodenum of small intestine?
- Iron - Vitamins A and B1 - Calcium - Glycerol - Fatty acids, monoglycerides - Amino acids - Monosaccharides and disaccharides
Where are most of the nutrients absorbed?
Jejunum
Where is vit B12 and bile salts absorbed ?
Terminal ileum
Large intestine absorbs _____
Water and electrolytes (The large intestine eliminates drier residues as feces)
What does the liver produce?
- Bile - Albumins - Lipoprotiens - Clotting factors (prothrombin and fibrinogen) - Angiotensinogen
What is the normal Bilirubin Pathway?
- RBC 2. Spleen (lysis) 3. Globulin and Heme 4. Iron and Porphyrin Ring 5. Biliverdin 6. Bilirubin 7. Bilirubin + Albumin = Unconjugated (indirect, non-H2O soluble) 8. Blood 9. In Liver 10. Albumin and Bilirubin + Glucuronic acid - Conjugated (direct, H20 soluble) 11. To gallbladder
Does the Liver digest?
Yes, due to the production of bile
What is bile?
A mixture of water, bile salts, cholesterol, the pigment bilirubin
What does the Liver store?
- Vitamins A, D, B12, K, and E - Glycogen - Iron - Copper
What does the Liver do to Detox?
- Converts ammonium to urea - breaks down insulin and other hormones - breaks down toxic substances
Does the Liver function to help with Immunity?
Yes, it contains Kupffer cells
What are Kupffer cells, and what do they do?
A fixed type of macrophage They play an important role by capturing and digesting bacteria, fungi, parasites, worn out blood cells, and cellular debris (Clean the large volumes of blood very fast)
What are the exocrine enzymes produced by the pancreas?
- Chymotrypsin - Trypsin - Carboxypeptidase - Elastase - Amylase - Lipase
What are the hormones the Pancreas produces?
- Insulin, Amylin - Glucagon - Somatostatin - Pancreatic Polypeptide
What are the actions of Amylin?
- Inhibits the secretion of glucagon - Slows emptying of the stomach - Sends a satiety signal to the brain
What does Glucagon do?
Increases glucose in blood, acts principally on the liver where it stimulates the conversion of: - Glycogen in glucose - Fat and protein into glucose
What are the functions of Somatostatin?
- Reduces the rate at which food is absorbed from the content of the intestines - regulates/stops alpha and beta functions
Pancreatic polypeptide ________ appetite?
REDUCES
What is Achalasia? (Cardiospasm)
An esophageal motility disorder involving the smooth muscle layer of the esophagus, and the lower esophageal sphincter (LES)
What is Achalasia characterized by?
- Incomplete relaxation of LES - It’s increased tone - Lack of peristalsis of esophagus
What is Primary Achalasia?
MC** Characterized by failure of distal esophageal inhibitory neurons - The Auerbach’s plexus (myenteric plexus)
What does the Auerbach’s plexus (or myenteric plexus) provide?
Motor innervation to both layers of the muscular layer, having both para and sympathetic output
What is special about Meissner’s plexus?
It has ONLY parasympathetic fibers and provides secretor innervation to the mucosa nearest the lumen of the gut
What could secondary Achalasia result from?
Cancer of esophagus or upper stomach
What else could Secondary Achalasia result from?
Infection with Protozoa (Trypanosoma Cruzi) which causes destruction of the myenteric plexus of the esophagus with its dilation
Achalasia caused by Tripansoma cruzi is known as _____
***Chaga’s Disease SECONDARY ACHALASIA
What are the signs and symptoms of Achalasia?
- Dysphasia 2. Regurgitation 3. Chest pain 4. Coughing 5. Aspiration of food or liquid
What is “Dysphagia” associated with Achalasia?
Difficulty in swallowing of solid or liquid food
What is “Regurgitation” associated with Achalasia?
Backflow of undigested food
Why would you have chest pain with Achalasia?
BEHIND THE STERNUM With radiation to the neck or armS* (NOT JUST ONE ARM) Can be extremely painful and gets worse AFTER eating
Why would there be “Coughing” with Achalasia ?
Cough when you’re in a HORIZONTAL position especially at night
What will you see on X- Ray with Achalasia?
Use contrast liquid swallowing shows the narrowing of the distal part of esophagus
What is the radiographic sign apparent with Achalasia?
“Bird’s Beak” or “Rat’s Tail” sign** Along with dilation above
How is there a diagnosis of Achalasia?
Upper Endoscopy (Gastroscopy)
What are the 3 complications of Achalasia?
- Aspiration pneumonia or airway obstruction 2. Lower esophageal diverticulum 3. Esophageal Cancer (in 5% of patients)
What do you recommend to patients with Achalasia ?
- Eat slowly - Avoid eating near bed time - Avoid ketchup, citrus, chocolate, caffeine - Physician consultation
What is a Hiatal Hernia of the esophagus?
Protrusion of the upper part of stomach into thorax through the space between the muscular Curran’s of the diaphragm (hiatus)
What are the different forms of Hiatal Hernia?
- Sliding MC* 2. Rolling or Paraesophageal
What happens during a Sliding Hernia?
Where the gastroesophageal junction together with the stomach move above the diaphragm
What type of dilation do you see with a sliding hernia?
Bell Shaped* MC form of hiatal hernia
What is a rolling or paraesophageal hernia?
When a separate portion of the stomach, usually along the greater curvature, enters the thorax through the widening foremen
What is condition can be an etiology of Hiatal Hernia?
Kyphoscoliosis
What are the etiologies associated with Hiatal Hernia?
- Increased pressure within the abdominal cavity - Congenital diaphragmatic weakness - Obesity, trauma
Hiatal Hernia is known as
Great mimic disease
What do most cases of Hiatal Hernia do?
Does not cause any symptoms or specific symptoms
Signs and Symptoms of the Hiatal hernia:
- Dull pain in chest - Shortness of breath - Heartburn (typical for sliding hernia) - Heart Palpitation (tachycardia)
How do you diagnose Hiatal Hernia?
X ray with liquid Barium salt, or upper endoscopy
What are the differential diagnosis of the Hiatal Hernia?
- Ischemic heart disease (chest pain) - GERD because of heartburn - Lung disease (short breath)
Ulcer in the esophagus is a complication of what disease?
Hiatal Hernia
What is there a stricture of in the complication of a Hiatal Hernia?
Stricture of esophagus
What can the complication of Rolling Hernia be?
Development of venous infarction due to its possible strangulation by the diaphragm *** EMERGENCY ***
What are the recommendations by the chiropractor with Hiatal hernia?
- Restrict activities that raise intra abdominal pressure - Avoid eating near bed time - Diet modification: small frequent bland food
What is Gastroesophageal Reflux Disease (GERD)?
A chronic syndrome resulting in mucosal damage caused by stomach acid coming up from the stomach into the esophagus