Exam 1 Flashcards
pharmacokinetics
investigation of absorption, distribution, metabolism and elimination of drugs
pharmacodynamics
mechanism of action of drugs
class of psychoactive drugs: cause neural and behavioral excitation
stimulants and convulsants
class of psychoactive drugs: reduce neural excitability, produce drowsiness, sedation and sleep, reduce anxiety symptoms
neural depressant, sedative-hypnotic and anxiolytics
class of psychoactive drugs: relieve pain, cause sleep
narcotic analgesics
why is drug action by PO administration less than other routes of administration
First pass effect through liver
acidic or basic drugs are often highly bound to plasma proteins and not in very high concentrations in tissues?
acidic
drugs with what functional group are often found in high concentrations in tissues
amine groups
at how many half lives is the drug considered gone from system
6
advantage of establishing the therapeutic range
patient adherence, avoiding toxicity, reducing costs of therapy
drug metabolism converts drug to more hydrophobic or more hydrophilic compound
hydrophilic so drug can be better eliminated through urine
phase I biotransformation reaction
introduce or unmask a chemically functional group (nonsynthetic)
Phase II biotransofrmation reaction
combines a functional group with an endogenous substance, making it less lipid soluble to be excreted easier (synthetic)
term for a drug jumping onto something that is endogenous to the body, making the metabolite more likely to be excreted from the body
conjugation
ways renal excretion can be increased
increasing volume of urine, changing pH of urine, increasing blood flow to kidneys
7TM receptors do they have g proteins
yes
distinguish ED50 EC50 and Emax, which one is Emax related to
ED50 is the dose required to produce a therapeutic effect in 50% of the population, EX50 is the concentration needed to produce a response that is 50% of the maximum response (Emax)
Therapeutic index (TI) = ? (what ratio, do we want it to be large or small number)
LD50/ED50. Large number please
slide 45-47 ppt 2
yes
organize highest to lowest level distributed systems, local circuits, nerve cell, specific behavior, genes, macromolecules, synapes, microcircuits
specific behavior, distributed systems, local circuits, nerve cell, microcircuits, synapse, macromolecules, genes
do enzymes reduce the amount of energy for a given reaction to take place?
yes. The availability of the enzyme determines the amount of the product
what type of enzyme phosphorylates proteins
protein kinase
what type of enzyme dephosphorylates proteins
protein phosphatase
Sense or antisense- strand of DNA used as the template for the RNA strand
sense
Who coined the term Eugenics, what is it
francis Galton. Intellectual abilities must follow the rules of inheritance in the same way as the physical traits of height and eye color (twin studies, behavior inherited)
what accounts for “missing heritability” in things like hypertension
epigenetics
forces that will determine ion movement across cell membrane
electrostatic forces and diffusion potential
what keeps neurons in resting state
Na-K pump
decremental conduction
signal gets weaker further away from source
Initial segment=trigger zone=?
axon hillock
what is the chemical that loewi discovered?
Ach
IPSP caused by movement of what ions
cl into k out of cell
slide 37 ppt 4
yes
two ways neurotransmitters are removed from the synapse
transporters (reuptake) and enzymes to metabolize them
MAO
monoamine oxidase- metabolizes monoamine neurotransmitters 5-HT, DA, NE
metabolizes catecholamines DA and NE
catechol-o-methyl transferase (COMT)
metabolizes acetylcholine
acetylcholinesterase
4 requirements to be a neurotransmitter
The neurotransmitter is present in the presynaptic neuron
The neurotransmitter is released in response to depolarization
There are receptors specific for the neurotransmitter located on the post-synaptic cell
- The neurotransmitter must be either metabolized or removed from the synapse (i.e. there must be a physiological mechanism to stop the ligand from being available to bind the receptor)
agents derived from a source external to a cell that act on receptors of a cell are called _____, different types are
first messengers -Neurotransmitters/Neuromodulators • Drugs • Hormones • Cytokines • Growth Factors
slide 51 ppt 4
yes
autoreceptors are not transporters
true
neuromodulators faster or slower than neurotransmitters
slower
what is volume transmission?
Often released from varicosities
- Usually involved in neuropeptide release
- Allows neuropeptide to interact with many post-synaptic neurons
what is a ubiquitous neurotransmitter, is glutamate one? is GABA one?
on every neuron, involved in every behavior, yes, yes
receptors for glutamate, ionotropic
NMDA, AMPA, Kainate
how many metabotropic receptor subtypes for glutamate, involved in what
8, producing cell products
GABAa ionotropic or metabotropic receptor, what does it mediate. post or Presynaptic receptor
ionotropic, inhibition caused by influx of chloride ions, postsynaptic receptor
GABAb metabotropic or ionotropic, post or presynaptic receptor
metabotropic, presynaptic (autoreceptor)
does serotonin act primarily on ionotropic or metabotropic receptors
metabotropic
drugs that promote what neurotransmitter activity are the most widely used antidepressants
serotonin
dopamine receptors are iono or metabotropic
metabotropic
where are serotonin neuron cell bodies located
raphe nuclei midbrain to hindbrain
three areas where dopamine neurons are located
ventral tegmental area (VTA), substantia nigra, arcuate nucleus
in order- metabolic cascade of these substances (what comes from what) l-dopa, tyrosine, dopamine, norepinephrine
tyrosine->l-dopa->dopamine->norepinephrine
three catecholamines
dopamine, norepinephrine, epinephrine
where is norepinephrine made
locus coeruleus
what nt contributes to anxiety disorders and PTSD
norepinephrine
what nt is in neurons that degenerate to cause alzheimer’s
ACh
which class of ACh receptors are ionotropic
Nicotinic
which class of ACh receptors are metabotropic
muscarinic
slide 65 ppt 4
yes
syndrome of fatigue and exhaustion of the muscle system, due to impaired ACh neurotransmission, autoimmune disease, due to destruction of postsynaptic ACh receptor
Myasthenia Gravis
What is myasthenia gravis caused by
Destruction of postsynaptic ACh receptor
How does neostigmine work? what does it treat?
treats myasthenia gravis by inhibiting acetylcholinesterase from breaking down ACh
neuropeptides almost exclusively act ionotropically or metabotropically
metabotropically
it is important to know that the amount of an amino acid in the brain is about three orders of magnitude greater than a biological amine or acetylcholine, that and in turn, the concentration of a biological amine or acetylcholine in the brain is about three times that of a neuropeptide.
yes
slide 73 ppt 4
yes
slide 8 ppt 5
yes
what brain division are these part of- cerebral hemispheres, amygdala, hippocampus, basal ganglia, septum
telencephalon
what brain division are these part of- thalamus, hypothalamus
diencephalon
what brain division are these part of- cerebellum, pons, medulla
hindbrain
Why is there more gray matter in coccyx than in cervical spine?
The higher you go up, the more information you are exchanging, more axons are present
what structure connects the thalamus and the hypothalamus
the massa intermedia
what brain division are these part of- pons and cerebellum
metencephalon
what part of the brain? inferior colliculus and superior colliculus. also substantia nigra and periaqueductal grey matter
midbrain: mesencephalon
What section of the brain- medulla oblongata
myelencephalon
what brain circuit is involved in parkinsons
basal ganglia
name structures in basal ganglia
amygdala, striatum (caudate plus putamen), globus pallidus
what is the reticular activating system
nuclei in the brainstem that have ascending projections that send neurochemicals to thalamus for communication with the cortex- for sleep. damage causes persistent sleep
what brain circuit- amygdala, striatum (caudate plus putamen), globus pallidus
basal ganglia
what brain circuit- amygdala, hippocampus, cingulate cortex, fornix, septum, and mamillary body- what is it in charge of
limbic system- emotions and drives
limbic system, whats in it and what is it in charge of
amygdala, hippocampus, cingulate cortex, fornix, septum, and mamillary body- emotions and drives
between what membranes are brain vasculatures
pia and arachnoid
areas that lack a blood brain barrier, allow brain to communicate with the body are?
circumventricular organs
circumventricular organs
areas that lack a blood brain barrier, allow brain to communicate with the body