Exam #1 Flashcards
1
Q
Mechlorethamine IV
A
alkylating agent
SE: powerful vesicant, NV, myelosuppression, infert, steril, carcinogen, mutanagen, teratogen.
2
Q
cyclophosphamide
A
alkylating agent
hepatic activation
non-enzymatic toxic metabolite (acrolein)
enzymatic (aldehyde oxidase) = non-toxic metabolite
3
Q
uracil mustard
A
alkylating agent
4
Q
chlorambucil PO
A
alkylating agent
less reactive than mechlorethamine (e- delocalization)
5
Q
Bendamustine
A
alkylating agent
6
Q
Ifosfamide
A
alkylating agent
