cancer drugs Flashcards by Robert Perry | Brainscape

Q

methotrexate

A

folic acid derivative antimetabolite

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Q

leucovorin

A

folic acid derivative antimetabolite

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Q

pemetrexed

A

folic acid derivative antimetabolite

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Q

pralatraxate

A

folic acid derivative antimetabolite

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Q

5-Fluorouracil

A

pyrimidine analog antimetabolite

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Q

fluorodeoxyuridine

A

pyrimidine analog antimetabolite

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Q

cytarabine

A

pyrimidine analog antimetabolite

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Q

gemcitabine

A

pyrimidine analog antimetabolite

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Q

doxorubicin (adriamycin)

A

anthracycline ( DNA intercalators, antitumor antibiotics)

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Q

danunomycin (danuorubacin)

A

anthracycline ( DNA intercalators, antitumor antibiotics)

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Q

idamycin

A

anthracycline ( DNA intercalators, antitumor antibiotics)

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Q

mitoxantrone

A

anthracycline ( DNA intercalators, antitumor antibiotics)

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Q

dactinomycin

A

anthracycline ( DNA intercalators, antitumor antibiotics)

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Q

epirubicin

A

anthracycline ( DNA intercalators, antitumor antibiotics)

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Q

valrubicin

A

anthracycline ( DNA intercalators, antitumor antibiotics)

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Q

dexrazoxane

A

cytoprotective agent for doxorubicin SE: (enhances myelosupression of doxorubicin)

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Q

camptothecan

A

topoisomerase I inhibitor

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Q

topotecan

A

topoisomerase I inhibitor

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Q

irinotecan

A

topoisomerase I inhibitor

Q

etoposide

A

topoisomerase II inhibitor

Q

teniposide

A

topoisomerase II inhibitor

Q

paclitaxel

A

inhibits depolarization (anti-mitotic)

Q

docetaxel (taxotere)

A

inhibits depolarization (anti-mitotic)

Q

ixabepilone (ixempra)

A

inhibits depolarization (anti-mitotic)

Q

vincristine (oncovin)

A

inhibits polymerization (anti-mitotic)

Q

vinblastine (velban)

A

inhibits polymerization (anti-mitotic)

Q

vinorelbine

A

inhibits polymerization (anti-mitotic)

Q

vindesine

A

inhibits polymerization (anti-mitotic)

Q

eribulin mesylate (halaven)

A

inhibits polymerization (anti-mitotic) 
metastatic breast cancer

Q

maytansine

A

inhibits polymerization (anti-mitotic)

Q

rhizoxin

A

inhibits polymerization (anti-mitotic)

Q

Cabzitaxel (jevtana)

A

inhibits depolymerization (anti-mitotic) 
prostate cancer

Q

imatinib (gleevec)

A

inhibitors of receptor tyrosine kinase

chronic myeloginos leukemia

Q

ibrutinib (imbruvica)

A

inhibitor of burton’s tyrosine kinase (B cell malignancies)
Mantle cell lymphoma
chronic lymphocytic leukemia

Q

afatinib (gilotrif)

A

inhibits EGFR and HER2 tyrosine kinases

metastatic non-small cell lung cancer (NSCLC) with EGFR mutations

Q

ceritinib ( zykadia)

A

inhibits ALK, IGF-1R, InsR (insulin receptor), and ROS1 tyrosine kinases
alk + metastatic non-small cell lung cancer (NSCLC)

Q

temsirolimus

A

inhibits mTOR a protein serine/threonine kinase and G1 growth arrest
advanced renal cell carcinoma

Q

everolimus

A

inhibits mTOR a protein serine/threonine kinase and G1 growth arrest
advanced renal cell carcinoma

Q

vemurafenib (zelboraf)

A

inhibits mutant B-Raf in malignant melanomas

mutant B-Raf + metastatic melanoma

Q

trametinib (mekinist) (+) dabrafenib (tafinlar)

A

trametinib inhibits MEK, while dabrafenib inhibits B-Raf (V600E/K mutants)
mutant B-Raf + metastatic melanoma

Q

bortezomib (velcade)

A

inhibits 26s proteasome

multiple myeloma

Q

carfilzomib (kyprolis)

A

inhibits 20s proteasome

multiple myeloma

Q

vorinostat (zolinza) oral

A

histone deacetylase inhibitor

non-hodgkins t-cell lymphomas

Q

romidepsin (istodax) IV

A

histone deacetylase inhibitor

non-hodgkins t-cell lymphomas

Q

panobinostat (farydak)

combination with bortezomib and dexamethasone

A

histone deacetylase inhibitor

multiple myeloma

Q

belinostat (beleodaq)

A

histone deacetylase inhibitor

relapsed and refractory peripheral t-cell lymphoma (PTCL)

Q

IFL

A

irinotecan, 5-FU, and leucovorin

colorectal cancer