Exam 1 Flashcards
Skeletal muscle is an _______ system.
ORGAN system
Muscle makes up about __% of total body weight.
50% (muscle)
Skeletal muscles are used for (5)
movement stability communication control of body openings and passages heat production
type of muscle that controls body opening and passages.
Sphincter
skeletal muscles produce as much as __% of our body heat.
85% of our body heat
protection, elimination of heat and contraction of skeletal muscles depends on the _________ system
Integumentary System
Muscles would be unable to contract without the _______ system.
Nervous System
Skeletal muscle connective tissue from inside - out. (3 layers)
Endomysium
Perimysium
Epimysium
Which metabolic phase(s) of exercise benefits the most from carb loading
Phase 3
Which metabolic phase(s) benefit most from blood doping
Phase 2 (mostly, but also help other two phases)
Anabolic refers to the stimulation of _______ _______ and thus induction of growth
Protein Synthesis
3 forms of the anabolic steroid drug.
Oil Based (injected) Water Based (pills) Patches/gels
Development of breast tissue from steroids.
Gynecomastia
Anabolic steroid works physiologically by: (2)
Increase secretion of growth hormone
Activate protein synthesis and prevent protein breakdown
Chemical composition of muscle (%’s)
75% water
20% protein
5% others
Each muscle is provided with a _____ nerve fiber and _____ nerve fiber
Motor
Sensory
Motor nerves transmit ______/______ ______ from the CNS to each individual muscle fiber.
Efferent/Motor Impulses
Motor neuron + group of muscle fibers =
Motor Unit
More motor units = more _______
Precision
The branch of anatomy that deals with the skeletal muscle system
Myology
Muscle fibers are grouped into bundles known as _________
Fasciculi
Muscle fibers and fasciculi are bound together by _________ _______
Connective Tissue
Muscle fibers are extremely ________ and ____________
Long
Multinucleate
Each muscle fiber contains dozens to hundreds of _________
Myofiliments
Term used to describe the type of muscle increase, which is due to an INCREASE in the SIZE of each individual fiber.
Hypertrophy
Term used to describe the type of muscle increase, which is due to an increase in the number of muscle fibers
Hyperplasia
Cytoplasm of a muscle fibers
Sarcoplasm
Type I Fibers (_____) are found in muscles where ______, ________ or __________ contraction are required.
Type I Fibers (DARK)
long, sustained or continuous (contraction)
______ __ fibers are associated with endurance activities.
Type I
Type I fibers are also associated with relatively higher levels of __________ _______ activity.
Continuous Metabolic (activity) (type I fibers/endurance)
Type II fibers (_____) are found in muscles that are used for _______, _______ activities.
Type II Fibers (LIGHT)
Quick, Powerful (activities)
______ __ fibers are associated with speed and strength and __________ metabolism.
Type II (fibers)
(speed and strength)
Anaerobic (metabolism)
_________ and _________ make muscles red
Sarcoplasm
Myoglobin
_____ __ fibers have fewer capillary beds.
Type II
fewer capillary beds
_____ __ fibers have more mitochondria.
Type I
more mitochondria
______ __ fibers: more glycogen/less fatty acids
______ __ fibers: more fatty acids/less glycogen
Type II fibers: more glycogen/less fatty acids
Type I fibers: more fatty acids/ less glycogen
Which fiber type atrophy with aging
Type II Fibers
speed/power
Which fiber type contain more oxygen.
Type I Fibers
endurance
Muscle fibers that contract faster than type I but slower than type II fibers.
Intermediate Fibers
Intermediate Fibers have a greater resistance to ________ but histologically resemble type __ fibers.
(resist) Fatigue
(resemble) Type II Fibers
Muscles of weight lifters and sprinters contain a higher proportion of _____ __ fibers.
Type II Fibers
Muscles of marathon runner contain higher proportions of ______ __ fibers.
Type I Fibers
Cell membrane of a muscle fiber.
Sarcolemma
Part of muscle fibers that store and transport calcium ions to the myofibrils.
Sarcoplasmic Reticulum
Invagination of the sarcolemma which allow electrical impulses to enter the muscle fiber.
Transverse Tubules (T-System)
A red protein pigment which is found in the sarcoplasm of the fiber
Myoglobin
Myoglobin not only gives color to the muscle, but also stores the needed ________ that the fibers need to utilize for its metabolism.
Oxygen
Contractile apparatus of the muscle fiber
Myofibrils
Myofibrils are formed from longitudinally oriented bundles of ______ and ______ _________ known as __________
Thick and thin filaments
Myofilaments
Light areas of myofibrils
I-Bands
Dark areas of myofibrils
A-Bands
Light areas in the middle of each dark band
H-Bands
Thin dark line down the center of each H-band
M-Bands
Thin dark line in the middle of each I-band
Z-Lines
Each myofibril is composed of numerous units known as the __________
Sarcomere
The main protein of skeletal muscle
Contractile Protein
Contractile protein consists of ______ which is found mainly in the __-band, and ______ found mainly in the __-band.
Actin –> I-Bands
Myosin –> A-Bands
Two proteins that interact with one another to created movement - a contraction
Actin and Myosin
_________ _________ - Inhibits the interaction of actin and myosin and thus prevent __________ __________.
Regulatory Proteins (prevent) Indiscriminate Movement
The two most common regulatory proteins are….
Troponin
Tropomyosin
Both regulatory proteins recognize ________ as the signal to allow actin and myosin to interact with one another
Calcium
_______ eliminates the inhibition caused by regulatory proteins thus allowing contraction
Calcium
The nerve impulse from the _______ _______ stimulates the release of calcium from the __________ _________
(impulse from) Transverse Tubules
(release calcium from) Sarcoplasmic Reticulum
The released calcium binds with the _________ molecules on the ______ ________
(calcium binds with) Troponin molecules
(on the) Actin Filaments
The binding of calcium with troponin changes the shape of the nearby __________ molecule (moving it aside) and exposing the ______ ________ ______ on the actin molecule
(changes shape of) Tropomyosin molecules
(exposing) Myosin Binding Site
ATP
Adenosine Triphosphate
_____ allows myosin to interact with actin
ATP
It requires (less/same/more) ATP to relax aa muscle as it does to cause contraction
Same (amount of ATP)
Energy is provided by the breakdown of adenosine triphosphate into…
Adenosine Diphosphate
The ________ pathway takes place in the mitochondria
Aerobic
Which pathway is the more efficient way to breakdown ATP
Aerobic
The aerobic pathway prefers _____ ______ to produce ATP
Fatty Acids
Fatty acids are stored in the body’s fat cells as __________ and released into the blood during exercise.
Triglycerides
Phase one of metabolic…
time frame and fuel sources
Few minutes
Creatine Phosphate & Glycogen (are fuel sources)
As much as __% of the total glycogen stored in the muscle may be utilized during phase one of metabolic
20%
Phase two of metabolic shifts to…
The more efficient aerobic metabolism
Phase three of metabolic…
Shifts back to the anaerobic production of ATP…
Uses the remaining stored glycogen
Which phase of metabolic does carb loading benefit the most?
Phase 3
Which phase of metabolic does caffeine benefit the most?
Phase 2
Risks associated with blood doping… (4)
Rashes and Fever
Acute Hemolysis (breakdown of RBCs)
Transmission of Viruses
Fluid Overload (lead to kidney failure and clotting)
Two alternative methods to increase RBC concentration…
Erythropoietin (EPO)
High Altitude Bed
(anabolic steroids)
Anabolic refers to…
_________ refers to the development of secondary sexual characteristics.
Anabolic - Stimulation of protein synthesis
Androgenic - Sexual characteristics
Stacking is the term used when the user takes…
Several forms of the drug
_________ is a procedure where the user starts with a low dosage, raises to a peak, and then tapers back down
Pyramiding
Anabolic steroids are usually taken in cycles of…
And can be as high as ______ what would be used for therapeutic reasons
6 to 8 weeks
500x
The _____ the motor unit, the _____ fibers, the more precision a muscle carries out
SMALLER motor unit
LESS fibers
(more precision)
The _____ the motor unit, the _____ fibers, the more broad (less precise) activity a muscle carries out
LARGER motor unit
MORE fiber
(more broad activity/less precision)
The motor unit originates in a ______ ______ in the ________ (anterior) horn of the _____ ______ of the spinal cord or brain stem.
Motor Neuron (in) Ventral (horn of) Gray Matter
Motor unit terminates at the _________ of the ______ ______ at the _____________ ________.
Sarcolemma (of the) Muscle Fiber (at the) Neuromuscular Junction
Nerve ending portion of the neuromuscular junction
Presynaptic Portion
Sarcolemma of muscle fiber of the neuromuscular junction
Postsynaptic Portion
Space between nerve ending and sarcolemma
Synaptic Cleft
____ is released when a nerve impulse reaches the presynaptic portion.
ACH - Acetylcholine
ACH binding with specific receptor sites on the sarcolemma sets off an ______ _____ down the _______ _______ which leads to an interaction between actin and myosin and a muscle contraction
Action Potential (down the) Transverse Tubules
When ACH has completed its task, it will be broken down by the enzyme…
Acetylcholinesterase (ACHe)
The most common neuromuscular junction disorder
Myasthenia Gravis
With an autoimmune disorder involving the neuromuscular junction, the body produces abnormal antibodies, which damage and destroy the _____ _______ _____ on the ________ of the muscle fibers
(destroy) ACH Receptor Sites (on the) Sarcolemma
Myasthenia Gravis almost always starts by affecting…
Cranial Nerves (muscles of the eyes and face)
Many patients with myasthenia gravis will suffer from hyperplasia of the _______ ______
Thymus Gland
Tumor to the thymus gland
Thymoma
Competes with ACH molecules in binding to ACH receptors.
Nicotine
Prevents ACH from binding to the ACH receptor sites (but does NOT compete)
Snake Venom
Inactivates ACHe resulting in an accumulation of ACH at the postsynaptic portion.
Organophosphates
Blocks the release of ACH
Botulin Toxin
Botulin toxin is the toxin that is released from the bacteria know as _________ ________
Clostridium Botulinum
Define contracture
Muscle is in a contractive state for a prolonged period or permanently
The clavicle has how many primary and secondary ossification centers
2 primary
1 secondary