Exam 1 Flashcards
Keratin sulfate
Cornea, bone, cartilage
Chondroitin sulfate
Cartilage, bone, heart valves, tendons, ligaments. Increase with compression
Dermatan sulfate
Skin, blood vessels, tendons, ligaments. Increase with tensile strength
Fibronectin
Interacts with cell surface receptors and gags. Blood clotting components, denatured collagen, cytoskeleton
Laminin
In basement membrane. Bonds type 4 collagen, HS, and integrin
Chondronectin
Found in cartilage. Attaches chondrocytes to type 2 collagen.
Main PG of ligaments
Dermatan sulfate
Collagen content of ligament
Type 1, varying amounts of 3,4,5 and elastin
Collagen types in tendons
Primarily type 1. Type 3 in tendon sheaths. Types 4 and 5 in basal lamina of fibroblasts
Endotendon
Encloses fibers to form fascicles. Contains mostly type 3 collagen fibrils
Tensosynovium
Peritendon becomes a synovium filled sheath in tendons that are subjected to high levels of friction
Collagen types in cartilage
Type 2. Type 9 to interact with proteogylcans. Type 11 regulates fibril size
Main PG associated with cartilage
KS and CS in aggrecan
Collagen type in fibrocartilage
Type 1. Where little motion occurs
Main type of collagen in bone
Type 1
What does SAID stand for
Specific adaptation to imposed demand
Collagen type of fibroblasts
Type 1
Collagen type of chondroblasts
Type 2
Collagen type of osteoblasts
Type 1 and hydroxyapatite
Role of mast cells
Inflammatory mediators
Mesenchymal cells
Undifferentiated cells found in embryos. Can differentiate into different CT
Aggregan
Chains of KS and CS attached to hyalouranon. Creates osmotic swelling pressure in cartilage by attracting water
Fibrous synarthroses
Suture, gomphoses, and syndesmoses
Cartilaginous synarthroses
Symphysis and synchondroses
Hyalouranon
Non sulfated. Independent GAG. Maintains strength of cartilage.
Ruffini
Stretch (extremes of extension)
Pacini
Compression or changes in hydrostatic pressure
Golgi
Pressure and forceful joint motion
Unmyelinated
Noxious and non noxious mechanical or bio mechanical stress
Sutures
Connected by dense fibrous tissue. Edges overlap. Found in skull
Synostosis
Fusion of suture
Gomphoses
Situated like a peg in a hole. Tooth in mandible
Syndesmoses
Joined directly by ligament or membrane. Shaft of tibia and fibula.
Symphysis
Joined by fibrocartilage in form of disc or plate. Covered with lamina or hyaline cartilage. Intervertebral discs. Pubic symphysis
Synchondrosis
Connected by hyaline cartilage. Forms between ossifying centers in bone. Found in skull and areas of bone growth.
Stratum fibrosum
Outer layer of joint capsule. Type 1 collagen. Poorly vascularized, richly innervated.
Stratum synovium and two layers
Inner layer of joint capsule
Highly vascularized poorly innervated
Intima is composed of synoviocytes
Subsynovial tissue is outside Intima. Highly vascularized. Contains most of the joint receptors.
Uniaxial joints
Hinge
Pivot
Biaxial joints
Condyloid
Saddle
Triaxial joints
Plane
Ball and socket