Exam 1 Flashcards
Keratin sulfate
Cornea, bone, cartilage
Chondroitin sulfate
Cartilage, bone, heart valves, tendons, ligaments. Increase with compression
Dermatan sulfate
Skin, blood vessels, tendons, ligaments. Increase with tensile strength
Fibronectin
Interacts with cell surface receptors and gags. Blood clotting components, denatured collagen, cytoskeleton
Laminin
In basement membrane. Bonds type 4 collagen, HS, and integrin
Chondronectin
Found in cartilage. Attaches chondrocytes to type 2 collagen.
Main PG of ligaments
Dermatan sulfate
Collagen content of ligament
Type 1, varying amounts of 3,4,5 and elastin
Collagen types in tendons
Primarily type 1. Type 3 in tendon sheaths. Types 4 and 5 in basal lamina of fibroblasts
Endotendon
Encloses fibers to form fascicles. Contains mostly type 3 collagen fibrils
Tensosynovium
Peritendon becomes a synovium filled sheath in tendons that are subjected to high levels of friction
Collagen types in cartilage
Type 2. Type 9 to interact with proteogylcans. Type 11 regulates fibril size
Main PG associated with cartilage
KS and CS in aggrecan
Collagen type in fibrocartilage
Type 1. Where little motion occurs
Main type of collagen in bone
Type 1
What does SAID stand for
Specific adaptation to imposed demand