Exam 1 Flashcards
Antihistamine Action
Antianxiety agent that exerts CNS depressant activity at the subcortical level of the CNS, particularly the limbic system & the reticular formation. They potentate the effects of the powerful inhibitory neurotransmitter, GABA, thereby producing calming effects.
Antihistamine side effects
Antianxiety agent whose side effects include dry mouth, drowsiness, and/or pain at IM sites
Antihistamine Drug names
hydroxyzine, vistaril
sublimation
rechanneling of drives or impulses that are personally or socially unacceptable into activities that are constructive
isolation
separating a thought or memory from the feeling tone or emotion associated with it
regression
retreating in response to stress to an earlier level of development & the comfort measures associated with that level of functioning
rationalization
attempting to make excuses or formulate logical reasons to justify unacceptable feelings or behaviors
intellectualization
an attempt to avoid expressing actual emotions associated with a stressful situation by using the intellectual processes of logic, reasoning, & analysis
identification
an attempt to increase self-worth by acquiring certain attributes & characteristics of an individual one admires
denial
refusing to acknowledge the existence of a real situation or the feelings associated with it
compensation
covering up a real or perceived weakness by emphazing a trait one considers more desirable
undoing
symbolically negating or canceling out an experience that one finds intolerable
reaction formation
preventing unacceptable or undesirable thoughts or behaviors from being expressed by exaggerating opposite thoughts or types of behaviors
introjection
integrating the beliefs and values of another individual into one’s own ego structure
displacement
the transfer of feelings from one target to another that is considered less threatening or that is neutral
suppression
the voluntary blocking of unpleasant feelings and experiences from one’s awareness
repression
involuntarily blocking unpleasant feelins and experiences from one’s awareness
projection
attributing feelings or impulses unacceptable to one’s self to another person
Neurons are composed of…
cell body, axon, dendrites
classes of neurons
afferent, efferent, interneurons
neurotransmitters
allow nerves to communicate with other nerves & surrounding tissues/funcation can be disrupted by systemic chemical changes,disease, and drugs/allow normal behaviors,emotions & cognition when WNL
receptors
are the binding sites for neurotransmitters in the brain/ when activated cause nerve cells to be excited or inhibited/ can be dysfunctional in brain disease states
major categories of neurotransmitters
cholinergics, monoamines, amino acids, neuropeptides
monoamines
norepinephrine, dopamine, serotonin, histamine
acetylcholine
cholinergic responsible for sleep, arousal, pain perception, movement, memory
increased levels= depression
decreased levels= Alzheimer’s, Huntington’s, Parkinson’s
norepinephrine
monoamine responsible for mood, cognition, perception, locomotion, cardiovascular function, sleep, arousal
increased levels= mania, anxiety states, schizophrenia
decreased levels= depression
dopamine
monoamine responsible for movement & coordination, emotion, voluntary judgment, release of prolactin
increased levels= mania, schizophrenia
decreased levels= depression
serotonin
monoamine responsible for sleep, arousal, libido, appetite, mood, aggression, pain perception, coordination, judgment
increased levels= anxiety states
decreased levels= depression
histamine
monoamine responsilbe for wakefulness, pain sensation, inflammatory response
increased levels= associated with wakefulness
decreased levels= depression
GABA
inhibitory amino acid that slows down body acitivity, calming peacemaker in the brain
increased levels= decreases anxiety, reduces stress, increases focus
decreased levels= anxiety disorder, Huntington’s, schizophrenia, epilepsy, hypertension, cardiovascular disease
Glycine
inhibitory amino acid responsible for recurrent inhibition of motor neurons
increased levels= toxic, encephalopathy, hyptonia, lethargy, muscle twitching
decreased levels= spastic motor movements, poorly controlled seizures
excitatory amino acids
glutamate & aspartate
glutamate & aspartate
excitatory amino acids responsible for relay of sensory information in the regulation of various motor & spinal reflexes
increased levels=Huntington’s, temporal lobe epilepsy, spinal cerebellar degeneration
decreased levels= may contribute to developing schizophrenia & psychosis
endorphins & enkephalins
neuropeptides that modulate pain & reduce peristalis
substance P
neuropeptide that regulates pain & processing of inflammation
increased levels= depression, increases anxiety & disrupts sleep
decreased levels= Alzheimer’s, Huntington’s, increased itching in eczema, insensitive to pain
somatostatin
neuropeptide that dependent upon the part of the brain being affected stimulates release of dopamine, serotonin, norepinephrine & acetylcholine OR inhibits the release of norepinephrine, histamine & glutamate. Neuromodulator of serotonin in hypothalamus
hormones of the posterior lobe of the pituitary
vasopressin and oxytocin
hormones of the anterior lobe of the pituitary
growth hormone, thyroid stimulating hormone, adrenocorticotropic hormone, prolactin, gonadotropic hormones, melanocyte-stimulating hormone
sleep stages
0-Alpha 1-Beta 2- Theta 3-Delta 4-Delta REM-Beta
neurochemical influences on sleep/wake cycle
serotonin, & L tryptophan, norepinephrine, GABA, actylcholine
genotype
total set of genes in an individual
phenotypes
characteristics that are not only genetic but also may be acquired
neurochemicals that may influence the immune system
growth hormone, testosterone, epinephrine, norepinephrine, serotonin
antidepressants work by
blocking the reuptake of serotonin & norepinephrine
antipsychotics work by
blocking specific neurotransmitter receptors
benzodiazepines facilitate
the transmission of GABA
psychostimulants increase
the release of norepinephrine, serotonin, & dopamine
nucleus acumbens
compulsions, locomotor activity
thalamus
weigh station for incoming sensory signals
hypothalamus
instinctive & appetite systems
brainstem
alerting, stimulus filtering, sleep, autonomic control
stress
the state manifested by a specfic syndrome that consists of all the nonspecifically induced changes within a biologic system
adaption
restoration of homeostasis to the internal environmental system
general adaption syndrome
- alarm reaction stage
- stage of resistance
- stage of exhaustion
precipitating event
a stimulus arising from the internal or external environment & perceived by the individual in a specific manner
primary appraisal
a judgment about the situation in one of the following ways: irrelevant, benign-positive, stress appraisal
seondary appraisal
an assessment of skills, resources, & knowledge that the person possesses to deal with the situation
cognitive appraisal
an individual’s evaluation of the personal significance of an event or occurrence
stress management
the use of coping strategies in the response to stressful situations
adaptive coping strategies…
protect the individual from harm & restore physical and psychological homeostasis
list some adaptive coping strategies
awareness, relaxation, meditation, problem-solving, pets, music, interpersonal communication with caring individual
Who associated mental illness with an irregularity in the interaction among the four humors?
Hippocrates
What four humors did Hippocrates associate with mental illness?
blood, black bile, yellow bile & phlegm
practice of the middle ages where the mentally ill were sent out to sea to search for their lost rationality
ship of fools
1st asylums for the mentally ill were established
in the middle ages in Middle Eastern Islamic countries
1st hospital in America to admit mentally ill
Philadelphia- mid 18th century
father of American psychiatry initiated the 1st humane treatment for mentally ill in the United States
Benjamin Rush
19th century lobbyist successful in establishing state hospitals for the humane treatment of the mentally ill
Dorothea Dix
1st American psychiatric nurse helped establish 1st school of psychiatric nursing 1882
Linda Richards
the successful adaption to stressors from the internal or external environment, evidenced by thoughts, feelings, and behaviors that are age-appropriate & congruent with local & cultural norms.
mental health
maladpative responses to stressors from the internal and external enviroment, evidenced by thoughts, feelings, & behaviors that are incongruent with the local & cultural norms & interfere with the individual’s social, occupational, or physical functioning
mental illness
anxiety disorder, somotaform disorders & dissociative disorders
psychoneurotic patterns of behavior
Peplau’s 4 levels of anxiety
mild, moderate, severe, panic
a diffuse apprenhension that is vague in nature and is associated with feelings of uncertainty & helplessness
anxiety