Exam 1 Flashcards
Pitocin MOA
Synthetic oxytocin
Stimulates uterine contraction (CTXN) and milk let-down
When is Pitocin used
Induction of labor
Postpartum hemorrhage (PPH)
Pitocin route and dosages
IV
Induction: 1-2 milliunits/min, increased every 15-20 mins
PPH: 125-200 milliunits/min or 10-20 units IM
Nursing considerations for Pitocin
Monitor FHT and CTXN q 15 mins
Monitor for uterine tachysystole - more than 5 contractions in 10 mins over 30 min window
Decrease Pitocin if uterine tachysystole or baby distress occurs
Cytotec (misoprostol) uses
Cervical ripening
Tx for postpartum hemorrhage
Cytotec (misoprostol) routes
Oral, vaginal, rectal
Cytotec (misoprostol) adverse effects
H/A
N/V/D
Fever/chills
Nursing considerations for Cytotec (misoprostol)
For:
Cervical ripening - continuous fetal monitoring
Postpartum hemorrhage (PPH) - monitor vaginal bleeding and uterine tone
Methergine (methylergonovine) uses
Tx of uterine atony (soft uterus) and PPH (postpartum hemorrhage)
Methergine (methylergonovine) route and dose
0.2 IM q 2-4 hours
Up to 5 doses
Methergine (methylergonovine) adverse effects
HTN & hypotension
N/V
H/A
Tinnitus
Dizziness
Contraindications for Methergine (methylergonovine)
HTN or pregnancy induced HTN - AE
Preeclampsia
CVD
Lactation
Nursing considerations for Methergine (methylergonovine)
Check BP before giving (do not give if >140/90)
Monitor vaginal bleeding and uterine tone (therapeutic effect)
Hemabate (carboprost/15methyl pg f) uses
Postpartum uterine bleeding r/t uterine atony
Hemabate (carboprost/15methyl pg f) route and dose
0.25 mg (250 mcg) IM q 15-90 mins
Hemabate (carboprost/15methyl pg f) adverse effects
Explosive diarrhea
N/V
H/A
Fever/chills
Tachycardia
HTN
Contraindications for Hemabate (carborprost/15methyl pg f)
Asthma
HTN
Cardiac, pulmonary, or hepatic disease
Nursing considerations for Hemabate (carboprost/15methyl pg f)
Administer with antidiarrhea (adverse effect)
Monitor vaginal bleeding and uterine tone (therapeutic effect)
TXA (Tranexamic acid) use
PPH
TXA (Tranexamic acid) route and dose
1g slow IV injection
Mixed with 50 or 100 mL IVF
- Administer over 10 minutes
TXA (Tranexamic acid) adverse effects
Hypotension
Visual abnormalities
N/V/D
Anaphylaxis
Contraindications for TXA (Tranexamic acid)
Hx or risk of thromboembolic disease
Caution with pt with renal impairment
Nursing considerations for TXA (Tranexamic acid)
Monitor hemodynamic - assessing for thromboembolic events (contraindication)
Magnesium sulfate MOA
CNS depressant
Relaxes smooth muscle - uterus
Magnesium sulfate uses
Preterm labor
Pregnancy induced HTN
Preeclampsia
Magnesium sulfate route
IV
Magnesium sulfate doses
Loading dose: 4-6g over 20-30 mins
Maintenance dose: 1-4 g/hr
- D/c within 24-48 hrs
Limit of 125mL/hr
Magnesium sulfate adverse effects
Maternal
- Hot: Flashes, sweating, burning IV site, dry mouth, drowsiness, blurred vision, H/A, weakness, lethargy, dizziness
- Hypocalcemia
- Transient hypotension
- Dyspnea
Intolerable AE
- RR less than 12/min
- Pulmonary edema
- Absent DTR’s
- Chest pain
- Severe hypotension
- Altered LOC
- UOP less than 30mL/hr
- Serum Mg 10 mEq or more
Fetal
- Decreased FHR
- Decreased fetal movement
Antidote for magnesium sulfate overdose
Calcium gluconate
Nursing considerations for Magnesium sulfate
Monitor DTR’s
- Increased = low Mg, Decreased = high Mg
Foley for strict I/O’s
D/c infusion if intolerable AE occur
Contraindications for Magnesium sulfate
Myasthenia gravis
Hypocalcemia
Renal failure
Brethine (terbutaline) MOA
Relaxes smooth muscle
Inhibits uterine activity
Causes bronchodilation
Brethine (terbutaline) uses
Tx of preterm labor
Brethine (terbutaline) route and doses
SQ
0.25 mg q 4 hours
Not for more than 24 hours
Contraindications for Brethine (terbutaline)
Dilated to over 4 cm
Suspected heart disease (AE)
Pregestational or gestational diabetes (AE)
Preeclampsia/eclampsia
Hyperthyroidism
Glaucoma
Seizure disorder
Brethine (terbutaline) adverse effects
Maternal
- Tachycardia, palpitations, chest discomfort
- Tremors, dizziness, nervousness
- H/A
- N/V
- Hypokalemia, hyperglycemia, hypotension
Intolerable
- Tachycardia over 130
- BP lower than 90/60
- Chest pain (not just discomfort)
- Cardiac arrhythmias/MI
- Pulmonary edema
Fetal
- Tachycardia
- Decreased FHR variability
Nursing considerations for Brethine (terbutaline)
Notify provider of intolerance adverse effects
Typically continuous fetal monitor is required
Procardia (nifedipine) MOA
Relaxes smooth muscle (uterus) by blocking calcium entry
Procardia (nifedipine) route and dose
PO
Initial dose: 10-20mg q 3-6hrs - until contractions are rare
Maintenance dose: 30-60mg q 8-12 hrs
Procardia (nifedipine) adverse effects
Maternal
- Hypotension
- H/A
- Flushing, dizziness, nausea
Fetal
- Hypotension
Contraindications for Procardia (nifedipine)
Intrauterine infection
HTN, cardiac disease
Do not give with magnesium sulfate (calcium is the antidote)
Do not give with or immediately after Brethine (terbutaline)
Do not give sublingual
Betamethasone or Dexamethasone MOA
Glucocorticoid
Stimulates fetal lung maturity by promoting the release of enzymes that produce lung surfactant
Betamethasone or Dexamethasone use
Prevent/reduce respiratory distress syndrome (RDS) in infants 24-34 weeks gestation
- Off label use
Betamethasone or Dexamethasone route and dose
IM
Betamethasone: 12mg in 2 doses, 24 hours apart
Dexamethasone: 6mg in 4 doses, 12 hours apart
Nursing consideration for Betamethasone or Dexamethasone
Must be given IM (ventral gluteal or vastus lateralis)
Assess BG in pt with gestational/pregestational diabetes
Narcan (naloxone hydrochloride) use
Reverse opioid induced respiratory depression in mother or newborn
Narcan (naloxone hydrochloride) routes
IV, IM, or SQ
Narcan (naloxone hydrochloride) doses
Adult: 0.4-2 mg q 2-3 min until 10mg
Infant: 0.1 mg/kg for infants over 5 kg
Narcan (naloxone hydrochloride) adverse effects
Hypotension or HTN
Tachycardia, hyperventilation
N/V
Sweating, tremors