Exam #1 Flashcards
What is immunity?
The bodies specific response to a foreign antigen or organism
What is the purpose of the immune system?
To fight off foreign bodies that can infect our body
What type of cells fight off infection?
WBC
What instances can raise WBC?
Infections or trauma
When a WBC response is triggered what is also triggered?
Inflammatory response
What type of diseases attack your own healthy tissues?
Autoimmune diseases
What occurs in the body with a hypersensitivity?
It is when your body has a inappropriate response to specific antigens
What are some examples of hypersensitivities?
Peanut, dog, cat, pollen, latex
What happens inside the body with a primary deficiency disesease?
Improper development of the immune system
How do you get a primary deficiency disease?
Through genetics/inheritance
Changing of genetic make up
What are some examples of primary deficiency diseases?
Sickle Cell, HIV/Aids
What is a secondary deficiency?
a disease that is developed later in life and is a result of a primary disease
What is an example of a secondary disease and how it develops?
A person with HIV has a supressed immune system gets Pneumonia
The pneumonia is the secondary disease
Can secondary diseases alter genetic make up?
Yes
What parts of the body do rheumatic diseases effect?
Muscles, bones, ligaments, and joints
In rheumatoid arthritis is inflammation primary or secondary?
Primary
In rheumatoid arthritis what happens if the inflammation of the body is controlled?
The patient will get relief because the inflammation is what is causing the problems in the first place
In degenerative diseases what happens to the patients condition if inflammation is controlled?
Swelling will go down but their underlying condition/symptoms will still be present
What is an autoimmune disease?
A disease that attacks your own healthy tissues
In what rheumatic disease is inflammation secondary?
Degenerative, osteoarthritis
In what diseases is inflammation primary?
Autoimmune rheumatic diseases such as lupus, MS and Rheumatoid arthritis
What are some examples of rheumatic degenerative disorders?
Osteoporosis and osteoarthritis
Is osteoarthritis and osteoporosis inflammatory or non inflammatory?
Non inflammatory
What occurs in the body in patients with osteoarthritis?
The Cartlidge that protects the joint and allows smooth movements is worn down to the point that bones are rubbing on each other
What occurs in the body for patient with osteoporosis?
Their body is not regulating calcitonin and estrogen properly which prevents their bones from keeping the calcium they need to be strong
What are the differences between rheumatoid arthritis and osteoarthritis?
RA is an inflammatory disease while OA is noninflammatory
RA is bilateral where OA can be unilateral
Morning stiffness for RA can take between 30 up to an hour to go away whereas OA is better in less than 30 minutes
What is happening to the cartilage and synovial membrane in RA?
Cartilage is still in tact but the synovial sac is inflamed
What is happening to the cartilage and synovial membrane in OA?
Thinned cartilage but the synovial membrane is fine
Does RA or OA have crepitus?
OA
Does RA improve or worsen with use?
May improve
Does OA improve or worsen with use?
Worsens
Is RA or OA systemic?
RA
What is RA?
A chronic progressive systemic inflammatory disease that affects tissues and joints
How does RA damage joints?
Inflammation in the synovial sacs form growths called pannus that narrow the joint space causing pain, damage, and decreased ROM
Where does RA typically start and where does it go from there?
Starts in hands first and then goes on the knee and spine
What are some non systemic symptoms of RA?
Bone erosion, erythema, immobilization, contractures, deformities
What is erythema?
Warmth of the joint
What are some systemic symptoms of RA?
Anemia, anorexia, fatigue, depression, vasculitis, pericarditis, kidney disease, Sjögren’s syndrome, and Raynauds
What is anemia?
This occurs when you have a drop in your hemoglobin and hematocrit
Why is anemia bad?
Because you will not have enough hemoglobin to carry oxygen to your body
What are some symptoms of anemia?
Fatigue, weakness, SOB, pale skin, head ache, cold hands/feet, dizziness, irregular heartbeat, chest pain
What is vasculitis?
Inflammation of the blood vessels
What are symptoms of vasculitis?
Fever, headache, general body pain, hypertension, MI, stroke, nose bleeds, blood cough
What is pericarditis?
Inflammation around the heart
What does the patient feel when they have pericarditis?
Pain on inhalation but not on exhale
What can pericarditis be confused with?
heart attack / cardiac arrest
What should you in relation to the kidneys in RA patients?
Monitor creatinine, BUN, and urine output
What is Sjögren’s syndrome?
Any gland that produces xxxx goes dry….dry mouth and dry eyes
What is raynuads syndrome?
Blood vessels constrict in the hand and makes finger turn blue/pale and makes them numb
Why would a physician order an x ray for a RA patient?
To look for bone erosion and deformities
What labs are ran for a potential RA patient?
Rheumatoid factor, CBC, H and H, ESR, BMP, Liver enzymes
What does a rheumatoid factor show?
Looks for antibodies in the connective tissues
Why would a CBC test be ran on a RA patient?
Their immune systems are lowered so they are looking for possible infection
Why would physicians run a ESR on a potential RA patient?
to look for excessive inflammation
Why would a physician run a BMP on a potential RA patient?
To monitor for dehydration, electrolytes , BUN, and Creatinine
Why would a physician run a liver enzymes on a RA patient?
To get baseline numbers on to compare once starting RA medications….RA medications can affect the liver
What are goals of treatment for RA patients?
Decrease pain, inflammation, and slow the progression
What procedure can be done to help alleviate pain and restore function from RA?
Artherocentesis
What is a artherocentesis?
This a procedure where a physician will insert a large needle into a synovial sac and drain of the excess fluid
What medication is used during Arthrocentesis?
Lidocaine to numb the area
What is another term used for Arthrocentesis?
Joint aspiration
What education should you give to a post op Arthrocentesis patient?
Labs may be drawn, ice the site, don’t use heat, look for drainage, watch the swelling, and rest for 24 hours
What should RA patients do at home to improve their condition?
Take medications, rest, ROM exercises, ICE, heat, PT, OT, support groups, and self care
What are the risk factors for RA?
Women, age 30-60, having Epstein bar virus, genetics, physical / mental stress
What are you looking for in an immunity assessment in relation to physical assessment?
Hair and skin….rashes, lesions, erythema, hair loss, hair thinning, photosensitivity, dyshphagia, void patterns, stool or urine characteristics
What is lupus?
A chronic progressive system inflammatory autoimmune disease that causes organs and systems to fail due to remissions and exacerbations
What is occurring in relation to WBC in lupus?
The WBC are attacking healthy tissues
What are the risk factors for lupus?
Women, 30-45, African Americans, Asians, Hispanics, native Americans, native Hawaiians
Clinical manifestations of lupus?
Fever, pain in several joints (mimics RA?), fatigue due to anemia, weakness, amenorrhea, oliguria, anorexia, butterfly rash, photosensitivity, systemic issues
What can trigger lupus exacerbation?
Any stress to the body such as child birth, drugs, uv light
What systemic issues arise in lupus patients?
Alopecia,amonorhea pancytopenia, LOC, pleural effusion, lupus nephritis, pericarditis, raynauds syndrome
What is amenorrhea?
Irregular menstrual cycle
What is oliguria?
Decreased urine output
What does butterfly fly rash look like?
Dry, scaly, raised red rash on the face
What is alopecia?
Patchy hair loss
How can lupus cause changes in a patients LOC
Confusion, irritability, headaches, seizures, decrease sodium
What does pancytopenia mean?
Decrease in all blood cells which included anemia, neutropenia, thrombocytopenia
What is anemia?
Decreased RBC
What is neutropenia?
Decreased WBC
What is thrombocytopenia?
Decreased platelets
What is a pleural effusion?
Build of fluid between the lungs and heart
What does pleural effusion look like?
Wet cough, chest paints, SOB
What is lupus nephritis?
Damage to kidneys due to lupus effects
What are symptoms of lupus nephritis?
Fluid build up, decreased urine output, increased BP, increased creatinine, peripheral edema
What does pericarditis feel like for the patient?
Pain on inhalation but not on exhale
How is a diagnosis of lupus made?
Combination of H and P, skin biopsy, and labs
What skin is removed for testing?
The lesions or rashes
What labs are looked at for lupus?
Antinuclear antibody, rheumatoid factor, erhyrocyte sedimentation rate, basic metabolic panel, complete blood count, UA
What does the ANA/ antinuclear antibody lab show?
Shows the number of antibodies present for ????
What does the RF lab do in relation to lupus?
Helps determine if the patient has RA or Lupus
What does the UA look for in lupus patients?
Looks at BUN and creatinine levels to determine kidney function
What does the CBC look for in lupus patients?
WBC, H and H, and Platelets
What is the goal when treating lupus patients?
Prevent organ damage, reduce exacerbations, pain control, and reduce the disease effects that come with lupus
What education should be give to patients with lupus?
Inspect skin, avoiding prolonged sun exposure, wearing long sleeves, brimmed hats, sun block of 30 spf or higher, mild soaps with no perfume, avoid skin drying agents like make up and powders , and support groups
What does the antigen do on a blood cell?
It is the key for what can be accepted by that blood cell
What does the antibody do in a blood cell?
It prevents that blood type from being accepted by the body
What happens if a patient gets the wrong blood type?
Agglination
What happens during agglutination? ?
The persons receives the wrong combination for antigen and antibody….the body then clumps of these cells
Who is agglutination most common in?
Patients receiving many units of blood
What is a autologous infusion?
An infusion do with your own donated blood
What are some good medications to give pre transfusion to reduce the speed and effects of agglutination?
Benadryl, Tylenol,
What type of saline is used when transfusing blood?
Normal 0.9 saline
What is added to a IV line when infusing blood?
A filter
What should be done between infusing each unit of blood?
Changing the IV tubing????
What lab is run to determine patient blood type?
Type and screen
When would it be a good idea to use a transfusion warmer?
Patients with problems of thermoregulation or in patients that are receiving many units of blood
What is the max time a unit of blood can be infused for?
4 hours
What blood type is the universal donor?
O blood
What is the universal acceptor blood type?
AB
What are the types of blood transfusion reactions?
Febrile, hemolytic, and allergic
What are the symptoms of a febrile blood reaction?
Chills, fever, headache, flushing, tachycardia, and increased anxiety
What are symptoms of an allergic reaction during a blood transfusion?
Mild…Hives, pruritis, facial flushing, SOB, bronchospasms, anxiety