Exam 1 Flashcards

1
Q

What does the Hippocratic corpus contain?

A

Theories about the causes of disease
Techniques that the doctor should use to cure and prevent diseases
The way a doctor should behave

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2
Q

Which of the following statements about the relationship between philosophy and Hippocratic medicine is true?

A

Both early philosophers and Hippocratic doctors saw rationality as the correct religious attitude, not as a complete departure from religion.
There was a direct influence of Pre-Socratic ideas on Hippocratic Medicine.
The seeds of both traditions are already planted in the Homeric poems

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3
Q

Who came up with the four-element theory (everything is made up out of air, earth, fire, and water)?

A

Empedocles

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4
Q

Name features of Hippocratic medicine?

A

Attention to preventative medicine, especially in the form of dietary advice
Medicine is an art, not a set of rules to be applied automatically. The doctor must learn to size up each patient as an individual case.
The commitment to holism: one should treat the whole body, not just the one part of the body where we find an ailment.
Hippocratic doctors showed an admirable reluctance to engage in what we would now call “invasive procedures”: they knew that their art had serious limits.

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5
Q

First anatomical dissections of human bodies?

A

In classical Greek civilization, there was a firm taboo against the dissection of human bodies. Thus Aristotle, for instance, did not extend his program of anatomical investigations past fish and other animals to include humans.
The two main anatomists were named Herophilus and Erasistratus
They were carried out in Alexandria, perhaps in its famous Museum
The protection of the Ptolemies was a factor that contributed to them being carried out

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6
Q

What questions did the knowledge gained by the first human dissection raise?

A

How do the nervous system and blood vessels relate to breathing and the motion of muscles?
Can we now give a more detailed account relating our immaterial soul to these physical structures?
Should the human body be understood as a bewilderingly complex machine?

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7
Q

What theory did ancient authors hold about breath (pneuma)?

A

Veins are full of blood, but arteries are filled with breath (pneuma)
Nerves are allowing us to control our bodies through pneuma that passes along hollow channels within the nerves.
Pneuma is a kind of physical lifeforce that pervades and sustains the body

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8
Q

What important contribution to medicine did Herophilus make?

A

Contribution of terminology like the ‘pineal’ gland to modern anatomy
The distinction between the sensory and motor nervous systems
A treatise describing what makes someone a good midwife

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9
Q

Name the three classical ‘sects’ that differed in their opinion on how doctors should discover their treatments?

A

The methodists, empiricists, rationalists

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10
Q

How did the Empiricists think that doctors should discover their treatments?

A

They need only use experience, and in fact no theory is required.

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11
Q

How did the Rationalists think that doctors should discover their treatments?

A

They should have an understanding of the underlying causes of illness and health.

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12
Q

How did the Methodists think that doctors should discover their treatments?

A

They should identify the appropriate ‘commonalities’, the specific types of blockages or fluxes.

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13
Q

Of which part of philosophy did Galen think was especially useful for doctors?

A

Ethics, logic, physics

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14
Q

How does Galen define human health?

A

As that good condition, which enables us to carry out all our activities as nature intends

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15
Q

What aspects did not enter into Galens’ view of disease prevention and which did?

A

Letting blood did NOT
These did: The extent to which Patients bathe, the extent to which Patients take exercise, patients’ diet

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16
Q

What philosopher or philosophical school does Galen seem to follow most closely in his discussion of the soul?

A

Stoics (the Stoic idea that the soul controls the body through a pervasive ‘breath’ or pneuma is used extensively by Galen in his medical writings)

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17
Q

How easy does Hippocrates think it is to learn medicine?

A

Not easy at all. “Life is short and the art is long” he would say.

This makes sense, because he wants doctors to take a personal approach, waying all circumstances. Getting a feel for such complexity, and understanding the core issues takes time.

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18
Q

What is the relationship between pre-socratic philosophy and Hippocratic writers?

A

They originate from the same area in Greece, and more importantly they take the same rational approach to their object of study.
“Medicine and philosophy in the Greek world went hand-in-hand, especially in the generations leading up to the time of Socrates, Plato and Aristotle – the same period that gave rise to the understanding of medicine enshrined in the Hippocratic corpus.”

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19
Q

What was the attitude of Hippocratic doctors towards religion and how that’s different from other cultures?

A

They said: “In a sense all diseases are sacred, because they are brought about in our bodies by natural forces like the winds or the sun, and these forces are themselves divine. He concludes with an aphorism worthy of Heraclitus: all diseases are divine, and all are human.”

“Xenophanes, like the author of The Sacred Disease, saw rationality as the correct religious attitude, not as a complete departure from religion.”

“As one Hippocratic author says, ‘prayer is good, but in addition to calling on the gods, one should lend a hand.’”

The pre-socratics have influenced their culture. What stood out was the rational approach, which here also is described as “the right religious attitude”. This merger of reason and religion is typical of Greek culture.

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20
Q

What was the difference in treatment between rationalist and empiricist doctors?

A

“At first blush, it seems that the Rationalists and Empiricists would thus have offered very different treatments. Galen explicitly says that they did not. Rather, they would prescribe the same drugs and other treatments, recommend the same kind of diet, and so on (On the Sects, ch.4). The disagreement rather concerns method and justification.”

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21
Q

What did Galen think about empiricism, rationalism and Methodism?

A

“Galen wants to emphasize that he is not simply a Rationalist. A good doctor must also pay close attention to experience, both the findings of others and what one can discover for oneself. Thus he suggests that the best method is a kind of fusion of the Rationalist and Empiricist approaches. By contrast, he finds nothing to value in a third sect of doctors, the Methodists (On the Sects ch.6).”

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21
Q

How difficult did methodists think it is to learn medicine?

A

They believed anyone could be doctor in a few months and essentially reversed the sentence of Hippocrates which was “life is short, but the art is long” into “life is long, but the art is short”.

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21
Q

Who is the foundational thinker of the Methodist school, and what is his theory?

A

Asclepiades
“For Asclepiades, the body is made up of tiny particles. Disease results when corpuscles cluster in such a way as to block appropriate motions in the body, or scatter so that things flow too freely.”

“According to the Methodists, all bodily disorders come about because of one of three conditions: either a blockage, a flux, or a mixture of blockage and flux. They identified a limited number of certain so-called ‘commonalities’, specific types of blockages or fluxes that were revealed by evident signs, like inflammation or a leaking of fluid like pus or phlegm. Because the range of commonalities they recognized was relatively small, they thought it was easy to remember both them and the appropriate remedy in each case.”

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22
Q

How did Galen’s physiological system work, especially the bloodflow?

A

Part of blood passed through ventricle wall, mixed with pneuma, to brain > nerves > motion + sensation
Stomach < food

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22
Q

How did Galen demonstrate of the importance of the brain?

A

“He (…) realized that there are close parallels between human anatomy and the anatomy of non-human animals. He thus undertook to demonstrate that the brain, and not the heart, as claimed by Aristotle and the Stoics, is the seat of the ‘ruling faculty’ (hegemonikon). This could be accomplished by compressing different parts of an exposed brain in a living animal, with different impairments being observable as a result. Galen also showed in public dissections that tying off or cutting nerves branching from the brain could cause an animal to go lame in some of its limbs, or to become unable to use its voice. He remarks that this is particularly effective with a pig, since its screams prior to the cutting of the nerve are so loud, creating a more impressive effect when the animal is suddenly rendered mute (On Anatomical Procedures K 2.663).”

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23
Q

In what did Galen’s methodological rigor consist?

A

“Galen refuses to commit himself on matters that cannot be settled by solid proof.” Which means to say that he highly valued empirical evidence. He did also engage in philosophical thought about nature, especially in so far as it had a bearing on medicine.

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24
Q

What is Galen’s view on ethics, physics and logic for a doctor?

A

Galen “encouraged all doctors to undertake the study of philosophy. He even wrote a little text on the subject, with the self-explanatory title The Best Doctor is Also a Philosopher. Adopting the Stoic division of philosophy (see above, chapter 8), he says that doctors can profit from all three branches of philosophy (K 1.60-61). Ethics will help him focus on the welfare of his patients, rather than the potential of his art for making money. Physics will help him understand the composition of the human body: the four elements, which lend their properties of hot, cold, dry and moist to the humors, for instance. And logic will train the doctor in the rules of demonstration, ensuring that he accepts theories that are not merely plausible but actually well-grounded.”

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25
Q

What does Galen’s refutation of atomism consist of?

A

We can see how he thought atomism can be refuted by turning to his still extant treatise On the Elements According to Hippocrates. Here he complains that atoms are meant to be unalterable and to remain ‘unaffected’. They can be moved around and bounce off each other, but they can never feel anything. Imagine pricking your skin with a needle (K 1.420-24). How would you feel the pain if your body were made of atoms? An atom will not feel a needle jabbing into it, since it cannot be affected. Nor does it matter how many atoms the needle strikes: the concussion of atoms will never yield the sensation of pain.”

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26
Q

What is Galen’s teleological understanding of nature, and what is its inspiration?

A

He agreed with Plato’s Timaeus, Galen sees the entire universe as bearing the marks of intelligent design, with the example of the human body to support this perspective. Moreover, Galen also thought that material possibility does place constraints on what nature can do which was also inspired by Timaeus. Galen further talks about nature as exhibiting the providence of a divine craftsman.

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27
Q

What did Galen’s anecdote with emperor Marcus Aurelius illustrate?

A

It elucidated how Galens own medical method is a compromise of the approaches of rationalists and empiricists. Furthermore, it illustrated his belief on how doctors should apply a personalized approach, providing a tailored treatment with respect to the patients particular needs. This was elucidated by Galen comparing Marcus’ pulse to what it should be for an old man.

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28
Q

What was the influence of Galen on philosophy?

A

He is one of the five ancient philosophers who is most influential on later philosophy. This is also due to many philosophers being doctors. Galen’s centrality in medicine outlasted that of Aristotle in philosophy. Therefore, when authors such as Avicenna and Descartes pondered the nature of humankind they had to factor in the most recent physiology and anatomy which was provided from Galen’s works.

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29
Q

You have a headache, and are in a medieval city. Which were seen as a licit option to go to for a cure?

A

A qualified doctor, The Church, A local healer

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30
Q

Name ways of medieval diagnosis?

A

Feeling the pulse of the patient, Examining the urine sample of the patient, Treating each patient as an individual

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31
Q

What would a medieval doctor prescribe?

A

Unguents, potions and other herbal treatments, Bed rest, a special diet and relaxation, Bleeding off superfluous blood

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32
Q

What sources did Paracelsus use for his thought?

A

Medicine, Magic, Natural Philosophy, Religion

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33
Q

In what area did surgeons NOT make headway in the Middle Ages? and which did they?

A

They did NOT develop correct understanding about how donated organs will be rejected by a host
They did: They treated wounds with antiseptics instead of letting them putrefy, They developed techniques for skin-grafting, They developed techniques for reconstructing noses

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34
Q

What did NOT contribute to the emergence of human dissection during the middle ages? and what did?

A

Professional physicians looked down on surgeons as manual workers because they used their hands. Professors also stayed well away from this work, which assistants would carry out.

The first dissections may have been post-mortem examinations intended to ascertain cause of death for legal purposes
Bologna was a pre-eminent place to study law, the first dissections took place in Northern Italy.
Pope Innocent is on record for ordering the forensic examination of a murder victim, helping to break the taboo.

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35
Q

How did Vesalius see himself in relation to Galen?

A

He saw himself as carrying though Galen’s project to its logical conclusion – investigating man himself.

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36
Q

Who contributed to the insight that air is absorbed into the blood in the lungs before being transported around the body?

A

Realdo Columbo, Michael Servetus, Ibn al-Nafis

37
Q

Who dealt the heaviest blow to Galen’s medical reputation?

A

William Harvey, Harvey’s discovering of the circulation of the blood dealt a crippling blow to Galen’s reputation as a reliable source on the workings of the human body. Galen wasn’t just wrong in the details, his entire system explaining the basic mechanics of life was flawed. This held both for humans and animals.

38
Q

What was thought to be the difference between a magical and miraculous cure?

A

There was a fundamental difference between the two. The magician who performed the magic cure had the power to heal people on his own accord. A miraculous cure, on the other hand, required the supplicant to rely on God as the decision maker and accept the fact that the sick might or might not be healed based on many unknown factors.

39
Q

What was the position of the Church regarding physicians or village healers?

A

The Church had no objections regarding physicians and village healers, at least those that didn’t resort to diabolical magic. They thought that it was God who was responsible for sickness and therefore also provided humans with means to deal with it.

40
Q

What circumstances helped make medicine a sholarly field?

A

Previously medicine was not considered a scholarly field but this was changed with the appearance of Arabic and Greek medical texts in the 12th century. The texts presented an impressive array of theory behind ancient medical practice. Before 1100 medicine was not considered a scholarly field as doctors used their hands to treat their patients and educated people viewed these skills similar to those if a craftsman rather than a scholar. Moreover, we could trace the origins of medicine back to Greek scholars such as Galen, a prolific writer, who became the standard authority on medicine in both the Roman and Muslim worlds.

41
Q

Why were medieval doctors instructed to be pessimistic about their patients?

A

Doctors were taught to be pessimistic about the prognosis so that if the patient recovered the doctor would be praised more for their skill and if the patient died his acquaintances would testify that the doctor had given him up. There was also the risk of the doctor loosing their fee if they claimed the patient was on the road to recovery but then died, as elucidated by Alderotti ignoring the instructions for medieval doctors.

42
Q

What Galenic and Paracelsus’ medicine tell us about ‘empirical observation only’ approaches?

A

Galenic and Paracelsus medicine was based mainly on empirical observation. Though they did have different beliefs, both took on different type of pain reliefs that were actually more harmful than not (prescribing antimony and mercury). Their works did not produce any type of real attack on disease as they had no knowledge of its cause. A real change only happened during the Middle Ages with the introduction of human dissection. We can thus say the ‘empirical observation only’ approaches were not effective.

43
Q

What is Servetus’ attitude towards Galen and what is its motivation?

A

Servetus found Galen’s work on blood and air to be full of inconsistencies. Galen had thought that pores existed in the heard that separated the right and left ventricles, and that veins and arteries never met. This meant that there was no circulation of blood and thus blood had to be continually created and destroyed. Servetus in his own worknoted that it was not possible for this to be the case and deduced that that all blood in the bodypasses thoughthe arteries. Air was then absorbed into the lungs beforebeingtransported to the body.

44
Q

Why and how did William Harvey affect Galen’s reputation?

A

At the start of the 17th century, there was a breakthrough that dealt a crippling blow to Galen’s reputation: the discovery of the circulation of blood by Harvey. He showed that Galen was not just wrong in the details. His entire system explaining the basic mechanics of life was flawed. Harvey’s revelation was that valves prevent blood from flowing in the wrong way. As Harvey’s experiments were done on animals, Galen lost the defence that he had no access to human cadavers.

45
Q

What were the treatment possibilities after Harvey’s discoveries, and why they did not work out?

A

Although the authority of Galen had been seriously weakened by the likes of Paraceleus and Harvey, there was little effective improvement in clinical practices. Undermining the theoretical basis of medicine was no good if there were no new theories to replace them which could lead to new treatments. The four humors remained the basis of diagnosis because there was no alternative. Attempts to use Harvey’s insights to carry out blood transfusions fell foul of what we now know are differing blood groups. If a patient is transfused with the wrong blood group they will die. As doctors had no conception of what a blood group was, the treatment was often fatal for no apparent reason.

46
Q

What is NOT an aspect of the change Noble expects systems biology to effect? and what are?

A

Reducing a biological system to its parts and studying these parts exhaustively.

Integrating the parts of the system to understand the whole, using rigorous methodology.
A change in our philosophy when thinking about life, in the full sense of the term.
Starting from the reductionist approach, but taking these results a step further.

47
Q

What is the central theme of Noble’s book ‘The Music of Life’?

A

There is no such thing as a program of life and there is no privileged level of causality in biological systems.

48
Q

What is Noble’s purpose in introducing the Silmans?

A

To show that the relationship between experience and material reality should not be explained in a simplistic way.

49
Q

Name problems with genetic determinism (Noble)?

A

DNA ‘expression’ is a complicated process that involves many other factors outside the DNA, like the active excision of parts of the DNA code by proteins.
One stretch of coding DNA can be processed in different ways to produce different ‘splice variants’ over the course of an organism’s lifetime.
Because genes interact, it is very difficult to label genes with higher-level functions in organisms.

50
Q

What, does Noble suggest, is the origin of the appeal of genetic determinism?

A

It is an over-extension of the selfish gene metaphor, it has been taken too literally

51
Q

Noble says that life is not a protein soup. Which reasons does he give to argue this point?

A

Because a systems – level analysis shows proteins interact in very intricate ways
Because a soup does not explain what makes a man a man and a dog a dog
Because the phenotype needs explanation, not the individual proteins

52
Q

Why does Noble tell the story about the Chinese Emperor and the poor farmer?

A

To make clear that combinations of genes behave in a highly non-linear way

53
Q

What does it mean that the difference between chimpanzees and humans is only 4% of our genes?

A

That 4% of our genes interacting among themselves, with all the other genes and with the rest of the body makes all the difference

54
Q

Noble argues against the idea that the genome is the ‘book of life’. What are his arguments?

A

Knowing the genetic code does not teach us about the control processes that dictate what proteins are being produced.
Amino acid sequences are revealing, but do not teach us all we need to know to get to know the three-dimensional structure of the protein it produces.
Knowing the genes does not teach us about interactions: interactions between genes, gene-protein interactions, and protein-protein interactions, for instance.

55
Q

What is the point of Noble’s story about Parisian chef’s trying to reproduce the famous omelets of a family bistro?

A

Just like the family mother did not write down in the recipe what she found ‘natural’, nature contains much supplementary information that genes do not contain.

56
Q

What is Noble’s answer to the challenge that the genome can still be seen as the book of life, if only we take into account the fact that languages are ambiguous, and function in a context of implicit knowledge that the language itself does not need to spell out, just like the genome?

A

The genome is not a book, because it does not contain a story. A story needs relationships, but the genome contains no information about these relationships.

57
Q

What factors does Noble mention that contain information we ‘inherit’ in the sense that we need it to be able to develop?

A

DNA, chemistry of water, chemistry of lipids, mitochondria

58
Q

Why is the genome not a program? (Noble)

A

Because the expression of the genome is regulated via feedback controls. The cell tells the genome what to do, and modifies its products.

59
Q

Noble’s main biological conclusion at the end of chapter 4?

A

There is no privileged level of biological causation that orchestrates the other levels, all levels interact in complex ways.

60
Q

In his first attempt on modeling the heart rhythm on a computer, Noble was stopped because he did not have an ‘oscilator’ in his equations. (An oscillator is a function that goes up and down of itself, like a sine or cosine function). Why was the oscilator function not necessary?

A

The oscilation is a systems-level (or emergent) property

61
Q

What happens when you turn off the feedback mechanisms in the heart beat model?

A

The heart stops beating, there is no more rhythm

62
Q

Why is systems biology not reductionism?

A

Because there is downward causation

63
Q

The ‘period’ gene seems to be a ‘single-gene system’ for producing rhythm at first sight. Which arguments explain why it is not?

A

It is not a single gene system, because the system can only function in the context of a working cell.
It is not a single gene system, because it is part of many other systems like embryonic development.
It is not a single gene system, because it may well have other functions next to the production of rhythm.

64
Q

Problems of the bottom-up approach?

A

Computability, It doesn’t include feedback mechanisms at higher levels, At the very lowest levels, quantum effects play a role, so biology is not determined

65
Q

What is the problem of the top-down approach?

A

It eventually leads to the same problems as bottom-up

66
Q

Name advantages of or insights associated with the middle-out approach?

A

It takes into account the modular build-up of organisms
All levels can be the starting point of a causal chain, so any of them can be the starting point for successful simulation.
Computability

67
Q

Examples of what a middle-out approach can be applied to?

A

the heart, cholesterol metabolism, glucose metabolism

68
Q

What is the main point that Noble makes in his second Silman story, where the Silmans visit islands?

A

Every cell type in the body is like a ‘species’ on the ‘island’ of the individual human being, the inheritance of expression patterns in such a ‘species’ is completely robust.

69
Q

Why does Noble think that the Silman’s story is shocking?

A

Because it sounds like Lamarckism, which is thought to be the antithesis of Darwinism

70
Q

What is the genetic basis of cell differentiation?

A

A combination: it receives all genes plus the activation status, but can also activate or deactivate genes itself.

71
Q

What does Noble say is the key ingredient of multicellular organisms?

A

Harmony between the parts (the keys)

72
Q

What, does Noble suggest, is a possible problem of making all cells receive the same genetic information?

A

There is a risk of side-effects: if you improve something for one organ, the same gene may have a negative effect in another organ.

73
Q

According to Noble, what should Lamarck justly be remembered for?

A

For having first introduced the term ‘biology’ and established it as a separate science

74
Q

What is meant by the ‘root’ of a human being in “Freedom in Quarantine”?

A

The core of what makes a human being human

75
Q

What is the “modern root”?

A

What is truly important about human beings are the results they deliver (the result principle)

76
Q

In accordance with the modern root, what kind of ethics is most important?

A

Consequentialist ethics

77
Q

In accordance with the modern root, health is…

A

a product

78
Q

Living according to the modern root leads to a mentality characterized by…

A

Unrest, unquiet, anxiety

79
Q

What is the “classical root” of the human being?

A

The notion of ‘act’, especially the act of being human, and the act of knowing

80
Q

What were the classical ethical ideals?

A

Theoretical: be able to rationally contemplate the world; practical: conduct your life virtuously, according to practical reason.

81
Q

To what mentality does the classical root lead?

A

Quietness, serenity.

82
Q

What is the Christian root?

A

The person, which denotes uniqueness and loving personal relationships

83
Q

How should power and information be treated according to the Christian root?

A

Power should be delegated as much as possible, and information shared as much as possible

84
Q

What does the Christian root add to thinking about health?

A

Stable loving personal relationships are essential for health and wellbeing

85
Q

How did the discovery of the ‘timeless’ in philosophy start?

A

perhaps by looking at the stars, they thought the stars were fixed

86
Q

The importance of the “timeless” philosophy…

A

discovered some truths are timeless and led to the development of the ‘timeless perspective’

87
Q

Example of a timeless perspective…

A

Aristotles fundamental distinction: act and potency

88
Q

What is the notion of “act”?

A

Actuality is the motion, change or activity representing an exercise or fulfilment of a capacity when a capacity becomes real in the fullest sense

89
Q

The ways the M.A prepared for the Natural Sciences…

A

Institutional change
Technological advances
Metaphysical grounding
Theoretical (creating new theories)

90
Q

What other institutional change does Bynum suggest that the M.A bequeathed to us?

A

the hospital
the hierarchical division of medical practicioners
the university (where the elites of medicine were educated)

91
Q

Name the key progress made in the 19th century in medicine

A

Discovery of bacterial (Joseph Lister + Louis Pasteur), said it was better to wash their hands before things like giving birth, and no one believed him until this
Paved the way for antisepsis

92
Q

Name the key progress made in the 20th century in medicine

A

Biomedical models emerge:
- Health defined as the “absence of disease.”
- Disease caused by pathogens
- Behavioural sciences; health interdisciplinarity

Economics of providing healthcare
- Rise of information – its role in providing care
- Evidence-based practices in late

Rise of pharma
- penicillin + antibiotics
- Pharmaceutical companies & profits
- patients wanting “magic pill”

93
Q
A