exam 1

Question 1

receptors and neurotransmitters

ionotropic receptors

Answer 1

receptors coupled to ion channels

Question 2

receptors and neurotransmitters

when the ion binds to the receptor it…

Answer 2

causes channel to open

Question 3

receptors and neurotransmitters

sometimes

Answer 3

-receptors opens a channel that causes positive charged particles to enter
-more likely to have an action potential (excitatory)

Question 4

receptors and neurotransmitters

other times….

Answer 4

-receptors open ion channels that make negatively charged ions enter the cell
-more diff. to produce an action potential (inhibatory)

Question 5

receptors and neurotransmitters

metabotropic receptors

Answer 5

-slow receptors
-can be long lasting
-not tied to ion channel
-activation/release of G proteins
-G protein=can act like ionotropic receptor
can initiate synthesis of AMP
second messangers

Question 6

neurochemical mechanisms of drug action

Neurotransmitter synthesis

Answer 6

increase/decrease the synthesis of neurotransmitters

Question 7

neurochemical mechanisms of drug action

neurotransmitter transport

Answer 7

interfere with the transport of neurotransmitter molecules to the axon terminals

Question 8

neurochemical mechanisms of drug action

neurotransmitter storage

Answer 8

interfere with the storage of neurotransmitters in the vesicles of the axon terminal

Question 9

neurochemical mechanisms of drug action

neurotransmitter release

Answer 9

cause the axon terminals to release neurotransmitter molecules into the synapse prematurely

Question 10

neurochemical mechanisms of drug action

neurotransmitter degradation

Answer 10

influence breakdown of neurotransmitters by enzymes

Question 11

neurochemical mechanisms of drug action

neurotransmitter reuptake

Answer 11

block the reuptake of neurotransmitters into the axon terminsals

Question 12

neurochemical mechanisms of drug action

receptor activation

Answer 12

activate a receptor site by mimicking a neurotransmitter

Question 13

neurochemical mechanisms of drug action

receptor blocking

Answer 13

cause a receptor to become inactive by blocking it

Question 14

types of NT

acetylcholine

Answer 14

-highly involved in sensory systems and motor movement
-generally excitatory
-binds to more than one type of a receptor
-nicotine(agonist)- only binds to particular receptors
-NT’s bind to more than one receptor type

Question 15

Monoamines

norepinephrine

Answer 15

regulates hunger,alertness,and arousal

Question 16

Monoamines

dopamine

Answer 16

-L-Dopa (able to pass thru brain-blood barrier)
-Coordinated motor movements
-anticipation of pleasurable experiences

Question 17

Monoamines

seratonin

Answer 17

-found thruout the brain and gut
-implicated in sleep and mood
-90% or seratonin receptors in gut