exam 1 Flashcards
trephining
drilling a hole in the skull to release evil spirits
edwin smith surgical papyrus (ancient egypt)
recognize significance of nervous system
believe paralysis is due to damage to nervous system
Quran, old & new testament
never mention the brain only the heart
liver source of passion
stomach source of courage
bowels source of pity
Aristotle
mental capacities is a function of the heart
brain is a cooling system for blood
blood humor
sanguine
enthusiastic and social
yellow bile humor
choleric
decisive and goal oriented
black bile humor
melancholic
analytical, deep thinker/feeler
phlegm humor
phlegmatic
peaceful and quiet
Galen
“father of medicine”
dissected mortally wounded gladiators and animals
_____ transmitted info to and from brain
behavior created by animal spirits in the nerves
poor understanding of anatomy
divinci
intricate drawings of anatomy
Descartes
control of behavior is spinal reflexes
dualism (mind separate from body)
pineal gland is the seat of the soul
wilis
brain is an ordered system made by god
phrenology
bumps on head reveals one character
helps establish localized behavior
brocca
patients with damage to specific brain area struggle to produce speech
lashley
specific lesions failed to find specific area for memory
more critical damage leads to poorer performance
Antonj van Leeuwenhoek
invented the light microscope
camillo Golgi
made stain for neurons
nervous system was interconnected fibers
Santiago Ramon Cajal
nervous system is seperate individual cells
used Golgi stain for discovery
luigi Galvani
bio electricity using dead frog (legs)
otto loewi
used heart to determine chemicals influence electrical activity
Donald Hebb
electrical stimulation of neurons strengthened concentration?
basis of learning
between-subject design
in control OR experimental condition
within-subjects design
subject experiences ALL conditions at some point
correlational design
measure two variables without manipulation
somatic intervention
manipulate physiology to measure change in behavior
gives mechanism of action
behavioral intervention
manipulate behavior and measure physiology
CT scan
picture of brain using radiation
excellent structural information
can’t detect activiity
PET scan
chemical traces associated with proteins in the body
good at location and level of activity of a specific NT
poor resolution
MRI
radio frequency pulses spin hydrogen atoms
different tissues behave differently
high resolution and no radiation
can not detect activity
FMRI
measure oxygenated blood
high resolutions, detects activity, no radiation
can’t detect specific neurotransmitters
assumes blood correlates with neural activity
diffusion tensor tech (DTI)
detects movement of water in axons
tells what are connected
does not show direction
EEG/ERP/MEG
detects electrical activity through skull
electrical picture of the brain
useful for sleep or epilepsy
difficult to pinpoint activity
single cell recording
implant recording electrode into single neuron
can record activity in free moving animal
limited by electrode stability
Golgi stain
shows entire neuron
Nisil stain
shows only cell body
fluorescent microscopy
sample treated with light emitting chemical
degrades so needs fast acting
Protein/MRNA blotting
quantitative, non-subjective, reliable way to count cells
optical density
lose anatomical resolution
more objective than cell counting