Exam 1 Flashcards
What term was coined by Thomas Willis as a consequence of the case of Anne Green?
c. Neurology
Aside from saving Anne Green’s life, Thomas Willis and Christopher Wren also
a. created very accurate drawings of the brain.
b. came up with the names of a number of brain structures.
c. took the first steps that led to cognitive neuroscience.
d. All of the answer options are correct.
D IS THE CORRECT ANSWER
Each of the following are reasons why Willis is considered one of the early figures in cognitive neuroscience EXCEPT:
b. He gave frequent lectures on specific brain regions.
While studying brain function, it is often useful to think of development in terms of ____________, which is the perspective of _____________________.
b. survival; evolution
Which stance would most likely hold an assumption that physical elements of the brain are responsible for the conscious mind?
a. monism
René Descartes posited that the mind was separate from the body. However, he implicated a single brain structure, the pineal gland, as having what function?
b. connecting the mind and the body
Considering the perspective recommended for approaching cognitive neuroscience, which of the following would best explain how a cognitive function may have developed?
d. hunting and gathering
A central issue of modern cognitive neuroscience is whether specific human cognitive abilities
a. arise from networks of brain areas working together.
The discipline of phrenology was founded by
d. Gall and Spurzheim.
Phrenologists believed that the contour of the skull could provide valuable information about an individual’s cognitive capacities and personality traits. This approach was based on the assumption that
a. skull protrusions are caused by disproportionate development of the brain areas beneath them, which are responsible for different specific functions.
Localizationist is to ________ as holistic is to ________.
b. Gall; Flourens
Gall’s method for investigating phrenology was flawed because
c. he sought only to confirm, not disprove, the correlations he observed.
The view known as aggregate field theory, which stated that the whole brain participates in behavior, is most associated with
d. Flourens.
The key observation leading John Hughlings Jackson to propose a topographical organization in the cerebral cortex was that
c. seizures begin in a localized region of the cortex.
In developing phrenology, Gall’s main failure was that
a. he did not seek disconfirming evidence.
b. he was not a scientist.
c. his method was correlational.
d. All of the answer options are correct.
D IS THE CORRECT ANSWER
Giovanni visits his local phrenologist. What is this person likely to tell him?
a. You are a domineering person.
The view developed by Marie Jean Pierre Flourens, based on the idea that processes like language and memory cannot be localized within circumscribed brain regions, was known as
b. aggregate field theory.
John Hughlings Jackson proposed a ________organization in the cerebral cortex, based on his work with people with ________.
c. topographic; epilepsy
________ was one of the first brain scientists to realize that specific cognitive functions can be localized to specific parts of the brain and that many different functional regions can take part in a given behavior.
b. Hughlings Jackson
Which 19th-century scientist suggested that the frontal lobe contributes to language and speech production?
c. Broca
Patient Leborgne was nicknamed “Tan” because that was the only word he could utter. Leborgne had developed an aphasia due to a lesion in which area of the brain?
b. Broca’s area
Which of the following things would have been the most difficult for the famous individual studied by Paul Broca to do, compared to before his stroke?
c. reading a book aloud
Which of the following things would have been the most difficult for the famous individual described by Carl Wernicke to do, compared to before his stroke?
a. understanding a speech
Wernicke was an early researcher who suggested that the ________ contributes to language comprehension.
d. left temporoparietal area
Wernicke is to ________ as Broca is to ________.
a. understanding speech; speaking
As a first approximation, individuals with damage to the left inferior frontal lobe tend to have more difficulty with ________, whereas individuals with damage to the left posterior temporal lobe tend to have more difficulty with ________.
c. the production of language; the perception of language
One reason that early research on specific human cognitive capacities and the brain areas that are responsible for them developed rather slowly before the 20th century is that
a. most early investigators were limited to postmortem studies to localize lesions.
Korbinian Brodmann used ________ techniques to document 52 regions of the brain that differed in ________.
c. tissue staining; cytoarchitectonics
Each of the following contributions led to the establishment of the neuron doctrine EXCEPT:
c. Thorndike’s observation of adaptive response.
Researchers Fritsch and Hitzig found support for the idea that specific functions are localized to discrete parts of the cortex in an experiment using electrical stimulation of a dog’s brain. More specifically, they found __ systematic relationship between the portion of the cortex stimulated and specific ________.
a. a; movements
Cytoarchitectonic maps distinguish different cortical regions by
b. their structure at the cellular level.
Yvette wants to figure out whether cells in two different layers of the occipital lobe have different functions. What would she have done if she had been a scientist in the early 20th century?
d. look at the layers under a microscope
The neuroanatomist who described 52 distinct cortical areas based on cell structure and arrangement, and whose classification scheme is often used today, was
c. Brodmann.
Which of the following terms refers to the idea of a continuous mass of tissue that shares a common cytoplasm?
b. syncytium
La reazione nera, or “the black reaction,” refers to
a. a cell stain developed by Golgi.
Which of the following scientists contributed to modern neuroscience in the 19th century?
a. Paul Broca
Which of the following statements best describes the “neuron doctrine”?
c. The nervous system consists of physically distinct cells that are functionally interactive.
The neuron doctrine is usually credited to ________, who used a staining technique pioneered by ________.
d. Ramón y Cajal; Golgi
The primary contribution of Golgi to the field of cognitive neuroscience was that he
a. developed a staining technique that permitted full visualization of individual neurons.
The term synapse, coined by Sherrington, refers to the junction between
c. two adjacent neurons.
Rationalism is the philosophical position that knowledge
c. must be deduced and justified through reason.
Empiricism is the philosophical position that all knowledge
b. originates from sensory experience.
Which of the following is NOT true of empiricism?
c. It postulates a special role for reason and induction in human thought.
Ebbinghaus, who is considered the father of modern memory research, was among the first to demonstrate that
d. internal mental processes can be measured in rigorous and reproducible ways.
All of the following are representative of the emergence of the field of cognitive science in the second half of the 20th century EXCEPT
b. a philosophical shift in the field toward empiricism and associationism.
Thorndike’s law of effect
c. stated that a behavior that is followed by a reward is likely to occur again.
____________ is the idea that all knowledge comes from sensory experiences, while ____________ holds that truth is intellectual.
a. Empiricism; rationalism
John Watson famously argued that newborn babies
c. can be raised to become anything.
According to associationist Herman Ebbinghaus, complex processes such as memory
d. can be measured in an analytic fashion.
According to Edward Thorndike, which of the following is NOT true about rewards?
a. They indicate which creatures have malleable structures in the brain.
“Cells that fire together, wire together” was first proposed by Donald Hebb as an explanation for
c. the way in which the brain codes new learning.
Noam Chomsky argued that the structure of human languages is ________, in contrast to
B. F. Skinner’s assertion that languages are ________.
a. innate; learned
Which of the following people did NOT play a strong role in the theoretical shift in psychology in the latter part of the 20th century?
b. Sir Charles Sherrington
Which of the following was NOT contributory to the development of the electroencephalogram?
b. studying patients who had skull defects
You decide that you want to measure blood flow of the brain. Which of the following methods would you employ to best achieve your goal?
d. None of the answer options is correct.
Computerized axial tomography is to MRI as ________ is to ________.
a. X-ray; radio frequencies
Which of the following methods relies on blood oxygenation?
b. functional magnetic resonance imaging
Suppose you are investigating neurological function, and one of the initial portions of your procedure is to inject radioactive oxygen-15 into the patient’s bloodstream. Which of the following methods are you most likely using to measure neurological activity?
c. positron emission tomography (PET)
A group of investigators is conducting research on brain tumors, and they need to obtain three-dimensional brain views to localize the tumors. Which instrument will provide the least invasive way to obtain their objective?
b. computerized axial tomography (CAT)
Imagine that you are one of the researchers who advanced the field of cognitive neuroscience by developing a new instrument to measure the brain. Computerized axial tomography (CAT) has already been developed, but your team wants to expand the CAT to develop an instrument that will provide information about brain function. Which method are you most likely developing?
c. positron emission tomography (PET)
Draw a diagram demonstrating the approach known as the scientific method. Your diagram should indicate the general procedures used and the order in which they are performed.
ANS: Answers will vary. Each should include the following: - make an observation - ask why it came about - form a hypothesis - design and perform an experiment - draw a conclusion - may also include replication
Describe how and why the term cognitive neuroscience was chosen for this field. Be sure to mention the two fields that combined to create this new field of study.
The scientific field of cognitive neuroscience received its name in the late 1970s in the back seat of a New York City taxi. One of us (M.S.G.) was riding with the great cognitive psychologist George A. Miller on the way to a dinner meeting at the Algonquin Hotel. The din- ner was being held for scientists from Rockefeller and Cornell universities, who were joining forces to study how the brain enables the mind—a subject in need of a name. Out of that taxi ride came the term cognitive neuroscience—from cognition, or the process of knowing (i.e., what arises from awareness, perception, and rea- soning), and neuroscience (the study of how the nervous system is organized and functions). This seemed the per- fect term to describe the question of understanding how the functions of the physical brain can yield the thoughts, ideas, and beliefs of a seemingly intangible mind. And so the term took hold in the scientific community.
Localizationists argued that higher cognitive functions were the product of brain activity in specific areas. Give evidence that they used to support their claims.
Gall became
convinced that the brain was the organ of the mind and that innate faculties were localized in specific regions of the cerebral cortex. He thought that the brain was organized around some 35 or more specific functions, ranging from cognitive basics such as language and color percep- tion to more ephemeral capacities such as affection and a moral sense, and that each was supported by specific brain regions.
Paul Broca and Carl Wernicke discovered two different forms of aphasia. Compare and contrast them.
Broca’s aphasia and Wernicke’s aphasia. Broca syphilitic lesion in his left-hemisphere inferior frontal lobe. This region is now called Broca’s area. The impact of this finding was huge. Here was a specific aspect of language that was impaired by a specific lesion. Soon Broca had a series of such patients.
Wernicke reported on a stroke vic- tim who (unlike Broca’s patient) could talk quite freely but made little sense when he spoke. Wernicke’s patient also could not understand spoken or written language. He had a lesion in a more posterior region of the left hemisphere, an area in and around where the temporal and parietal lobes meet, now referred to as Wernicke’s area
Describe the main tenets of the Neuron Doctrine.
The neuron doctrine states that the basic signaling unit of the nervous system are separate discrete cells with processes arising out of the cell body. Neurons can be divided into many different classifications based on the number of processes arising from the cell body. the nervous system is made up of individual cells. He also recognized that the transmission of electrical information went in only one direction, from the dendrites down to the axonal tip.
Describe the evidence that led Marie-Jean-Pierre Flourens to move the field away from localization toward aggregate-field theory.
He destroyed parts of the brains of pigeons and rabbits and observed what happened. He was the first to show that, indeed, certain parts of the brain were responsible for certain functions. For instance, when he removed the cerebral hemispheres, the animal no longer had perception, motor ability, and judgment. He could not, however, find any areas for advanced abilities such as memory or cognition, and he concluded that these were more diffusely scattered throughout the brain. All sensations, all perceptions, and all volitions occupy the same seat in these (cerebral) organs. The faculty of sensa- tion, percept and volition is then essentially one faculty. The theory of localized brain functions, known as local- izationism, fell out of favor.
A major question in cognitive neuroscience is the extent to which regions of the brain are independent or integrated. Which of these two viewpoints is most valid? Present evidence to support your view.
The brain is definitely more integrated than independent. Evidence to back this up is patients born with no corpus callosum and their brain compensates for that missing structure by still allowing communication between hemispheres through other commissures.
Associationism and empiricism are two main philosophical positions. Pick the one you think best describes how humans come to know things and explain why you think this.
Associationism is what best describes how humans come to know things. This is true because people aren’t born with a blank slate. People tend to learn from associating things like we have seen with conditioning experiments.
Describe the transition from behaviorist to cognitive approaches in psychology.
Miller concluded that the brain, among other things, is an information processor and, breaking the bonds of behaviorism, he realized that the contents of the mind could be studied, setting into motion the “cognitive revolution.”
Noam Chomsky wrote an article titled “Three Models for the Description of Language.” Describe how the findings he reported moved the field of cognitive psychology forward.
Chomsky showed how the sequential predictability of speech follows from adherence to grammatical, not probabilistic, rules. Chomsky’s deep message was that learning theory—that is, associationism could in no way explain how children learned language. The complexity of language was built into the brain, and it ran on rules and principles that transcended all people and all languages. It was innate and it was universal.
Describe two principal methods used to measure brain structure.
CAT scan consists of series of transverse X-rays could be reconstructed into a three-dimensional picture. Using mathematical techniques and multiple two-dimensional X-rays to reconstruct a three-dimensional image.
MRI scans work with the magnetic field temporarily realigns water molecules in your body.
The two main classes of cells in the nervous system are
c. neurons and glial cells.
In the nervous system, these cells provide structural support and insulation for neurons.
a. glia
Two main types of projections extend from the cell body of a neuron. ________ receive inputs from other neurons, while ________ send information to other neurons.
d. Dendrites; axons
Within a neuron, the transmission of information is usually ________. Between neurons, the transmission of information is usually ________.
c. electrical; chemical
The term concentration gradient refers to a difference in the
b. number of ions found on opposite sides of the cell membrane.
At the resting state, a higher concentration of ________ is found outside a neuron and a higher concentration of ________ is found inside a neuron.
b. Na+; K+
If you were to insert a microelectrode through the cell membrane of a neuron, you would be able to demonstrate that
b. the region inside the cell membrane is more negatively charged than the region outside the membrane.
The ease with which a cell membrane will permit ions to cross is referred to as
b. permeability
If you inserted a micropipette into a neuron without harming the cell and pumped in a small quantity of calcium ions, each of which carried two positive charges, how would this affect the membrane potential?
a. The membrane potential would become depolarized relative to the resting potential.
The Hodgkin–Huxley cycle describes how the depolarization of the membrane causes voltage-gated sodium channels to ________, allowing ________ sodium ions to enter the cell. This change in sodium concentration then causes ________ of the cell.
c. open; more; further depolarization
Ouabain is a toxin that works by permanently inhibiting the activity of sodium–potassium pumps embedded in neuronal membranes. How would ouabain administration affect the resting potential of a neuron?
a. The magnitude of the resting potential would shift toward zero.
The value of the membrane potential to which an axon must be depolarized to initiate an action potential is called the ________ potential for that neuron.
c. threshold
The poison tetraethylammonium (TEA) interferes with normal neural communication. The toxin binds to and blocks voltage-gated potassium channels in the neuron cell membrane. Which of the following best describes the effects of TEA on the action potential?
b. The repolarization phase of the action potential is blocked.
Demyelinating diseases such as multiple sclerosis disrupt normal neural communication by
c. causing deterioration of the fatty substance that normally coats and insulates axons.
The nodes of Ranvier are
d. points along axons that are not surrounded by myelin
The primary reason why neurons are refractory for a short period after firing action potentials, and the reason underlying the absolute refractory period, is that the
a. voltage-gated sodium channels are inactivated.
If electrical currents on multiple dendrites sum together at the axon hillock, and the current flows across the neuronal membrane to the spike-triggering zone, what is likely to happen?
a. An action potential will be initiated
The term saltatory conduction refers to the fact that
c. action potentials appear to jump from node to node in myelinated axons.
In which of the following diseases is myelin damaged or lost?
d. multiple sclerosis
___________ enable(s) the rapid transmission of action potentials down an axon and increase(s) the distance over which transmission can occur.
d. Myelin
The ___________, which is comprised of _________, restricts the diffusion of certain molecules and microbes from the circulatory system, protecting the brain from chemical compounds that might otherwise interfere with neuronal activity.
b. blood–brain barrier; astrocytes
Which of the following cells produce myelin in the peripheral nervous system?
d. Schwann cells
Which of the following cells devour and remove damaged brain cells?
b. microglia
Which of the following statements best describes the immediate consequence of neurotransmitter molecules binding to ligand-gated ion channel receptors?
a. Voltage-gated channels in the cell membrane open and permit ion flow through the membrane
The role of calcium ions (Ca2+) in synaptic transmission is to
b. mediate the release of neurotransmitter molecules from the presynaptic neuron.
Which of the following sequences of steps best represents the order of events that occur during synaptic transmission?
d. release of neurotransmitter from the presynaptic cell diffusion of neurotransmitter across the synapse binding of neurotransmitter at the postsynaptic membrane
Compare the following analogy to chemical synaptic transmission: Two postage companies use different methods for delivery. Company One’s method is to send a delivery person out with packages that will be delivered directly to the address on the label. Company Two’s method is to send a delivery person out to a transfer center, and a second driver will deliver the package to the address. Company One’s method best compares to ___________________, while Company Two’s method best compares to ___________________. Company ___ uses a faster method.
c. ligand-gated ion channels; G protein-coupled receptors (GPCRs); One
Consider the synapse shown schematically here.
If neuron A causes neuron B to become hyperpolarized relative to B’s resting state,
b. neuron B is less likely to release neurotransmitter molecules from its own axon terminal.
A gap junction is
c. a transmembrane channel that connects the cytoplasm of two cells at an electrical synapse.
Which of the following is a catecholamine?
d. norepinephrine
The effect of a particular neurotransmitter on postsynaptic neurons
d. depends on the properties of the postsynaptic neuron and may be modulated by the presence or absence of another neurotransmitter.
Which of the following is NOT a mechanism for removing a neurotransmitter from the synaptic cleft?
d. transport of the neurotransmitter by ion channels into neighboring glial cells
Many drugs produce their effects by facilitating or interfering with neurotransmitters at synapses. Which of the following drugs would most likely increase the effect of serotonin?
b. a drug that prevents the activity of an enzyme that breaks down serotonin molecules in the synaptic cleft
Cerebrospinal fluid (CSF) is produced in the lateral and third ventricles by the
d. choroid plexus.
The thick outer membrane that encloses the brain within the skull is the
d. dura mater.
The two main divisions of the central nervous system are the
c. brain and spinal cord
The difference between gray matter and white matter is that gray matter refers to ________, whereas white matter refers to ________.
c. cell bodies; axon tracts
Gray matter is to white matter as ________ are to ________.
c. cell bodies; axon tracts
The brainstem includes all of the following components EXCEPT the
c. hypothalamus
The specialized structures that comprise the midbrain control functions such as
b. visual reflexes.
The dorsal portions of the gray matter in the spinal cord carry
b. sensory information.
A patient has great difficulty in maintaining his posture, walking, and coordinating his movements. His brain injuries probably involve the
a. cerebellum.
A patient reports that she is functionally blind after a focal brain injury, even though her eyes and optic nerves are completely intact. Of the structures listed here, the most probable location for the brain injury is the
b. lateral geniculate nucleus
The part of the thalamus that is most important in relaying information to the primary visual cortex is the
a. lateral geniculate nucleus
This brain structure is often called the gateway to the cortex because almost all sensory inputs synapse here before continuing to their primary cortical sensory areas.
c. thalamus
Which of the following functions is NOT mediated primarily by the hypothalamus?
c. relay of sensory information from the body to the cortex
As a result of a brain injury to this diencephalic structure, a patient is experiencing disruptions in maintaining homeostasis of bodily states and endocrine control.
b. hypothalamus
Injury to the hypothalamus would most likely interfere with
a. hormone regulation
All of the structures listed here are major components of the basal ganglia EXCEPT the
b. amygdala
As a result of a brain injury to the medial temporal lobes and neighboring subcortical structures, a patient exhibits a number of cognitive and behavioral changes. Of the following options, which is the LEAST likely to be affected?
d. somatosensation
The ___________________ is a system of structures that includes the ____________. This system has been implicated in ________________________.
a. limbic system; amygdala; emotion behavior
All of the following are advantages of a folded cerebral cortex EXCEPT:
a. The need for blood vasculature in the cortex is eliminated.
Communication between the two hemispheres of the brain occurs mainly through the
c. corpus callosum
The corpus callosum
a. permits communication between the two cerebral hemispheres.
The most caudal lobe of the cerebral cortex is the ________ lobe.
c. occipital
Neurons in two different regions of Brodmann’s cytoarchitectonic map always
b. differ in cell morphology and organization
The temporal lobe is to the occipital lobe as ________ is to ________.
c. audition; vision
The morphology of the brain of Albert Einstein revealed an unusual Sylvian fissure, the division that separates the ________ lobe from the ________ lobes.
b. temporal; frontal and parietal
The central sulcus is an anatomical landmark that separates the ________ lobe from the ________ lobe.
b. frontal; parietal
The term cytoarchitectonics refers to
a. how cells in one brain region appear morphologically and how they are arranged with respect to each other.
Of the following choices, the most anterior portion of the frontal lobes—the prefrontal cortex—is most critical to
b. executive functions
The primary visual cortex, or V1, is located in
a. the striate cortex.
The neocortex contains ______ cortical layers, with ________ typically being the input layer.
c. six; layer IV
The frontal lobe is ________ to the occipital lobe, whereas the temporal lobe is ________ to the parietal lobe.
b. anterior; inferior
All of the following terms refer to the same cortical region that processes visual input EXCEPT
c. Heschl’s gyrus
The primary auditory cortex is organized using a tonotopic map, which means that there is an orderly representation of
b. frequency
A patient recently suffered a traumatic blow to the head. She reports that she is having social difficulties, such as adding inappropriate comments to conversations. She cannot seem to control these outbursts. Which area of her cortex is most likely affected?
c. the anterior frontal lobe
The volume of cortex that is not sensory or motor has traditionally been termed ________ cortex.
c. association
Parts of the brain where metabolic activity is relatively high are characterized by
a. elevated regional blood flow.
This type of early cell line is the precursor to the cells that will compose the nervous system.
d. ectoderm
Which of the following statements regarding the prenatal development of the human nervous system is correct?
b. Ectoderm cells are the precursors of the entire nervous system.
A team of scientists from California and Sweden (Eriksson et al., 1998) administered BrdU, a synthetic form of thymidine, to patients. Which of the following best summarizes the findings from these procedures?
d. New neurons are produced in the adult human brain.
____________________ refers to the process of rapid cell division that occurs early in development of the nervous system.
b. Neuronal proliferation
The cells in the brain that guide migrating neurons to their final locations are called
b. radial glia
Which of the following best describes the reason for substantial growth of the human brain from birth to adulthood?
c. The formation of synapses and growth of dendritic trees.
The cell body of a neuron contains the same machinery found in most cells, including a nucleus, ribosomes, and mitochondria.
True
Dendrites, which are large treelike processes extending from a neuron, are said to be presynaptic.
False
Action potentials are electrical signals that are conducted down the axon of a neuron.
True
The term selective permeability refers to the fact that a cell membrane will allow some ions to pass through more readily than others.
True
The resting potential of a neuron is typically +40 to +90 millivolts (mV).
False
The equilibrium potential is the membrane voltage at which there is no net flow of ions in or out.
True
Hyperpolarization makes the inside of a cell more positive and more likely to generate an action potential.
False
The amplitude of an action potential is directly proportional to the size of the initial depolarization that produced it.
False
If the sum of the excitatory postsynaptic potentials (EPSPs) causes a postsynaptic neuron to reach its threshold, then the postsynaptic neuron will generate an action potential.
True
Communication between two neurons is always achieved through chemical, and not electrical, mechanisms.
False
The term commissure refers to the white matter tracts that connect the brain and spinal cord.
False
Neural inputs that target the cortex and originate in the thalamus are referred to as corticothalamic.
False
The hippocampus is considered part of the neocortex.
False
Sulci are the protruding rounded surfaces of the cortex, and gyri are the fissures and invaginations between the sulci.
False
During development, a structure called the blastula begins to form when the neural plate invaginates via neural folds being pushed up at its border.
False
Describe the chemical and electrical properties of an action potential. In your answer, describe the movement of Na+ ions and K+ ions across the cell membrane and the resulting changes in electrical potential.
a) An idealized neuron with myelinated axon and axon terminals. Voltage-gated ion channels located
in the spike-triggering zone at the axon hillock and along the extent of the axon at the nodes of Ran- vier open and close rapidly, changing their conductance to specific ions (e.g., Na1), altering the mem- brane potential and resulting in the action potential (inset). (b) The relative time course of changes
in membrane voltage during an action potential, and the underlying causative changes in membrane conductance to Na1 (gNa) and K1 (gK). The initial depolarizing phase of the action potential (red line) is mediated by increased Na1 conductance (black line), and the later repolarizing, descending phase of the action potential is mediated by an increase in K1 conductance (dashed line) that occurs when the K1 channels open. The Na1 channels have closed during the last part of the action potential, when repolar- ization by the K1 current is taking place. The action potential undershoots the resting membrane poten- tial at the point where the membrane becomes more negative than the resting membrane potential
Explain the concept of electrochemical equilibrium. How does this concept allow us to understand the transmembrane potentials in neurons?
the force of the concentration gradient pushing K1 out through the K1 channels is equal to the force of the electrical gradient driving K1 in. When that happens, the opposing forces are said to reach electrochemical equilibrium. The differ- ence in charge thus produced across the membrane is the resting membrane potential, that −70 mV difference. The value for the resting membrane potential of any cell can be calculated by using knowledge from electrochemistry, provided that the concentrations of ions inside and out- side the neuron are known.
What are the major differences between electrotonic conduction and the action potential? Describe how these two processes play out in neural transmission.
The small electrical current produced by the EPSP is passively conducted through the cytoplasm of the den- drite, cell body, and axon. Passive current conduction is called electrotonic conduction or decremental conduc- tion: “decremental” because it diminishes with distance from its origin. The action potential doesn’t decrement after only 1 mm. Action potentials enable signals to travel for meters with no loss in signal strength, because they con- tinually regenerate the signal at each patch of membrane on the axon. The action potential is able to regenerate itself because of the presence of voltage-gated ion channels located in the neuronal membrane.
Describe the structure, and explain the function, of three types of glial cells.
Astrocytes
• Surround neurons and are in close contact with the brains vasculature
• Create the blood-brain barrier (BBB)
• Have an active role in brain function, e.g., modulate
neuronal activity •
Astrocytes are large glial cells with round or radially symmetrical forms
Oligodendrocytes
• Myelinate axons in the brain and spinal cord.
wrapping their cell membranes around the axon in a concentric manner during development and maturation.
• Microglial cells
• Phagocytes that devour and remove damaged cells
Microglial cells, which are small and irregularly shaped
How do two neurons communicate with each other? Describe the process of synaptic transmission, including both chemical and electrical synapses
Through synaptic transmission. Chemical transmission results in the release of neurotransmitters from the presynaptic neuron and
the binding of those neurotransmitters on the post- synaptic neuron, which in turn causes excitatory or inhibitory postsynaptic potentials (EPSPs or IPSPs), depending on the properties of the postsynaptic receptor. Electrical synapses are different from chemical synapses because they operate by passing current directly from one neuron (presynaptic) to another neuron (postsynap- tic) via specialized channels in gap junctions that con- nect the cytoplasm of one cell directly to the other. The general mechanism
• The arrival of the action potential at the axon terminal
leads to depolarization of the terminal membrane,
causing voltage-gated Ca2+ channel to open
• It triggers small vesicles containing neurotransmitters to
fuse with the membrane at the synapse and release the
transmitter into cleft
• The transmitter diffuses across the cleft and on reaching
the postsynaptic membrane, binds with specific receptors embedded in it
Choose six of the following eight brain regions. For each region, briefly describe its location in the brain and one of its functions. Draw a picture to accompany your answer. • frontal lobe • parietal lobe • temporal lobe • occipital lobe • basal ganglia • hypothalamus • thalamus • cerebellum
The frontal lobe is important for cognitive functions and control of voluntary movement or activity. The parietal lobe processes information about temperature, taste, touch and movement, while the occipital lobe is primarily responsible for vision. The temporal lobe processes memories, integrating them with sensations of taste, sound, sight and touch.
Thalamus is almost exactly in the center of the brain and perched on top of the brainstem (at the anterior end), the thalamus is the larger of the diencephalon structures. Responsible for
The thalamus has been referred to as the “gateway to the cortex” because, except for some olfactory inputs, all of the sensory modalities make synaptic relays in the thal- amus before continuing to the primary cortical sensory receiving area. Relay center.
Hypothalamus chief site for hormone production and con- trol. Easily located, the hypothalamus lies on the floor of the third ventricle
What are the advantages of a cerebral cortex with gyri and sulci? Why might the human cerebral cortex be more heavily folded than those of other mammals?
The folds of the human cortex serve two important functions. First, they enable more cortical surface to be packed into the skull. If the human cortex were smoothed out to resemble that of the rat, for example, humans would need to have very large heads. The total surface area of the human cerebral cortex is about 2,200 to 2,400 cm2, but because of extensive folding, about two thirds of this area is confined within the depths of the sulci.
Second, having a highly folded cortex brings neurons that are located at some distance from each other along the cortical sheet into closer three-dimensional relation- ships; for example, the opposing layers of cortex in each gyrus are in closer linear proximity than they would be if the gyri were flattened. Because the axons that make long-distance corticocortical connections run under the cortex through the white matter and do not follow the foldings of the cortical surface in their paths to distant cortical areas, they can project directly to the neurons brought closer together by folding.
Histological methods have been used to classify the cerebral cortex into different cytoarchitectonic divisions, such as the Brodmann areas. Can we predict the function of a brain region based on cytoarchitectonics? Why or why not?
We could but it isn’t enough just to use brodmann areas. It has to be used in conjunction with functions. A com- bination of cytoarchitectonic and functional descrip- tions of the cortex is probably the most effective way of dividing the cerebral cortex into meaningful units. Using different microscopic anatomical crite- ria, it is also possible to subdivide the cerebral cortex according to the general patterns of the cortical layers
Describe the events following the fertilization of an egg that pertain to the development of the nervous system. In your answer, name the three main types of cell lines found in the blastula and describe what parts of the organism these cells become.
The blastula contains three main cell lines that, after a few days, form three layers: the ectoderm (outer layer) that will form the nervous system and the outer skin, lens of the eye, inner ear, and hair; the mesoderm (middle layer) that will form the skeletal system and voluntary muscle; and the endoderm (inner layer) that will form the gut and digestive organs.
during the first
21 days of life. (a) Early in embryogenesis, the multicellular blastula contains cells destined to form various body tissues. (b) Migration and specialization of different cell lines leads to formation of the primitive nervous system around the neural groove and, after it fuses, the neural tube (not shown) on the dorsal surface of the embryo. The brain is located at the anterior end of the embryo
The field of ________ is based on the idea that perception and thought employ mental representations that undergo transformations as they are used.
c. cognitive psychology
Posner and his colleagues had participants view two letters and respond according to whether these letters were both vowels, both consonants, or one of each. Participants were fastest when viewing two physically identical letters, somewhat slower when viewing the same letter in two different fonts, and slowest when two different consonants were presented. This finding shows that
a. we form multiple representations of stimuli.
The Sternberg paradigm illustrates that when a set of letters held in short-term memory is tested with a recognition task, the time needed to respond to a probe item is
c. related by a linear function to the number of items in the memory set, the slope of which is the same regardless of whether the probe item was part of the original list.
People are better at identifying a briefly presented letter on a computer screen if the letter is
b. presented as part of a word.
The Stroop effect demonstrates that when viewing
d. words, we cannot help but activate word representations even when they are irrelevant to the task.
One of the experimental strengths of brain-lesion methods in animals, compared to human neuropsychology, is that
a. animal work can be truly experimental, whereas with humans we are limited to correlational inferences.
A blockage of the posterior cerebral arteries that resulted in brain damage would most likely cause a deficit in
a. vision.
A patient has an injury to the parietal lobe and has a selective deficit in processing information about the spatial location of visual stimuli. You hypothesize that this region of the brain is distinct in function from other visual areas in the temporal lobe, in which you suspect shape perception information is processed. To establish a double dissociation between the two functions and brain regions, you would need to find another person who had damage to the
d. temporal lobe and had only a shape perception deficit.
Which of the following is an advantage of the group study approach in neuropsychology, compared to the individual case study approach?
a. A group study allows a cognitive process to be related to particular underlying brain structures with greater reliability.
Which of the following degenerative disorders is believed to have the strongest genetic component?
c. Huntington’s disease
For which disorder have patients benefited from deep-brain stimulation of the basal ganglia?
c. Parkinson’s disease
What part of the brain does an angiogram allow you to visualize?
d. arteries
The driver in a car accident first hits the windshield with great force, then rebounds backward. Which part of the driver’s brain would you expect to be damaged as a result of the countercoup injury?
b. the posterior occipital lobes
________ is a condition characterized by excessive and abnormally patterned activity in the brain.
b. Epilepsy
Resecting or removing regions of cortex and cutting the corpus callosum are techniques that are usually used to
a. alleviate severe chronic epilepsy.
The term ________ is used to describe the situation in which group 1 is impaired on task X and unimpaired on task Y and group 2 is impaired on task Y and unimpaired on task X. In contrast, the term ________ is used when group 1 is impaired on task X and unimpaired on task Y and group 2 is unimpaired on both tasks X and Y.
b. double dissociation; single dissociation
For a researcher to provide evidence that a brain area and cognitive function are associated, they could use a _____________ dissociation, however, to provide more substantial evidence about the function and function localization, they would need a ______________ dissociation.
a. single; double
Transcranial direct current stimulation (tDCS) affects brain function by
a. altering neuronal polarization.
A knockout mouse
c. is part of a special genetic strain that lacks or no longer expresses certain genes.
The technique known as ________ can be used to induce virtual lesions in humans.
b. TMS (transcranial magnetic stimulation)
Which of the following imaging techniques would be best for visualizing a skull fracture?
a. CT (computerized tomography)
Which of the following imaging techniques can be thought of as a three-dimensional X-ray?
b. CT (computerized tomography)
This neuroimaging technique combines X-ray pictures taken from many different angles into a compressed two-dimensional representation of the brain
b. CT (computerized tomography)
Which of the following neuroimaging techniques involves manipulating the orientation of hydrogen atoms?
a. MRI (magnetic resonance imaging)
A magnetic resonance imaging (MRI) image is constructed from signals that are generated by
d. protons rebounding to the MRI’s magnetic field.
Diffusion tensor imaging (DTI)
d. is performed with an MRI scanner but measures the density and motion of water contained in axons.
You have isolated a neuron in the occipital lobes that you believe is responsible for processing information about color. What type of neurophysiological technique would allow you to assess this hypothesis in a living animal?
a. single-cell recording
The particular region of space in which a stimulus must be presented to evoke a response from a given neuron is its
c. receptive field.
What can you infer about the responsiveness of two neurons in the visual cortex that lie next to each other in V1?
c. The receptive fields of these cells are also next to each other.
One limitation of what we can learn through the single-cell recording technique is that
b. patterns of activity among groups of neurons may describe the function of a brain area better.
Which of the following types of topographic representation does NOT incorporate information about the location of a stimulus in space?
c. cochleotopic maps in the auditory cortex
The electrical signal evoked by a class of sensory, motor, or cognitive events, which is observed by averaging multiple EEG traces, is known as a(n)
c. event-related potential.
Research questions about the time course of cognition are better addressed using methods like ________, whereas questions about the anatomy of cognition are better addressed using methods like ________.
a. ERP (event-related potential); fMRI (functional magnetic resonance imaging)
Which of the following is an advantage of MEG (magnetoencephalography) over EEG (electroencephalography)?
c. With MEG, magnetic fields are not distorted by the skull.
Which of the following best describes the major limitation of MEG (magnetoencephalography)?
c. The MEG requires a magnetically shielded room.
The formation of plaques composed of abnormal amyloid protein in the brain is a characteristic symptom of
a. Alzheimer’s disease.
A patient suffering from a progressive neurological disorder is brought to a neurologist for diagnosis. The neurologist notes that the patient’s MRI reveals a great deal of cortical atrophy and suspects that the problem may be Alzheimer’s disease. Which of the following symptoms, if also discovered, would confirm this diagnosis?
d. presence of amyloid plaques during postmortem examination of the brain