Evolution Flashcards
Causes of variation
- random assortment
- crossing over
- non-dysjunction
- random fertilisation
- mutation
Random Assortment
chromosomes sorted into daughter cells randomly; many possible combinations of chromosomes coming from both mother and female
Crossing Over
Homologous pairs exchange different segments of genetic material
Non-dysjunction
Failure of chromatids to separate during meiosis
Random fertilisation
Any sperm can fertilise any ovum
Mutations
Permanent changes in the DNA - may result in new characteristics
Species
Organisms with shared characteristics that can produce fertile offspring
Population
A group of organisms of the same species living in a particular place at a particular time
Gene pool
The sum of alleles in a given population - can change over time (increase/decrease)
Allele frequencies
Measured in % - shows the frequency of a certain trait in a population
Allele frequency of cystic fibrosis
95% of population don’t carry CFTR gene - 5% frequency of cystic fibrosis allele
Evolution
Gradual change in phenotype thought to be caused by a change in allele frequency
Causes of Changes to Allele frequency
- Mutations
- Natural Selection
- Random Genetic Drift
- Migration
- Barriers to Gene Flow
- Genetic Diseases
Random mutations
Only a small section of DNA is affected, altering a single gene
Chromosomal mutations
many genes or the entire chromosome is affected
Somatic mutations (random mutations)
body cells experience mutation - dies out with organism
Germline mutations (random mutations)
Offspring from the affected gamete will inherit the gene; the individual is unaffected
Natural selection
Selection pressures make traits more favourable for survival - passed onto offspring
Random Genetic Drift
Usually only occurs in small populations - by chance, allele frequency changes (the traits aren’t advantageous)
Examples of Random Genetic Drift
Dunkers - small religious groups in Germany only intermarry; allele frequencies for blood groupings, mid-digital hair, ear lobes and handedness are different to the general population
Founder Effect
Allele frequency of emigrating group is different from the original population (Islander population vs Mainland)
Achromatopsia
Inherited total colour blindness - only 20 people survived following typhoon on Micronesian Island; allele frequency high
Migration
The gene flow from one population to another - individuals joining the population change the allele frequencies
Barriers to Gene Flow
Prevent interbreeding between populations - isolated population may be subjected to different environments with different selection pressures = different gene pools
Genetic Diseases
Expected that the frequency of a disease allele will decrease in population over time
Tay-Sachs Disease
Recessive autosomal disease
Homozygotes lack enzyme = build up of lipids in NS, die by 5 - high in Jewish populations because heterozygotes have immunity to tuberculosis
Sickle Cell anemia
Allele frequency high in African countries - heterozygotes have resistance to malaria
Natural Selection - Observations
- variation exists
- birth rate exceeds resource avaliability
- Nature’s balance - high birth rates, yet populations are stable
Struggle for existence
Organisms with variations that best suit their environment will survive
Speciation - steps
- variation (exists)
- isolation (occurs)
- selection (occurs)
- speciation
Speciation
Resulting changes in gene frequencies make it impossible for the two groups to interbreed
Effect of evolution
increase in the frequency of advantageous alleles, decrease in the frequency of disadvantageous alleles
Evidence for evolution
- fossils
- comparative studies
- geographical distribution
Comparative studies
Comparative biochemistry & comparative anatomy
Comparative biochemistry
DNA
Mitochondrial DNA
Protein sequences
Genomics
Comparative anatomy
Embryonlogy
Homologous structures
Vestigial organs
Comparative biochemistry - theory
Supports the ida that organisms are related to each other (share common ancestor) - gradual differences in DNA as organisms become more distantly related
Junk DNA
Non-coding DNA; the more closely related organisms are, the more junk DNA they have in common