EVO DEVO Flashcards
Lec 16
Mendelian inheritance
helpful in understanding of inheritance of traits, alleles, gene
deceptive - suggests that this is the most common way traits are created genetically, not complex, dominant/recessive
complex inheritance
many traits seem to be controlled by more than 1 gene or linked/inherited together
continuous - phenotypes are slight variations along a continuum
not all mutations are completely random
Embryology
the study of the differentiation of a single-celled fertilized egg into a complex multicellular organism
embryo development is remarkably similar across all chordates, in the earliest stages of development (ex: all start out with gill slits and tails)
Evolutionary developmental biology
discovery of genes which regulate embryonic development in eukaryote
link evolution to embryo
Homeobox genes
Fate Map
newly formed single cell (zygote) able to detect where is the center of the cell and assign cardinal points to corners of the cell, that helps map the rest of development (where things go)
The rest of the steps of the fate map
axes of zygote are subdivided into more lat and longitudinal lines, keeps dividing within zygote
each new square given a unique identity and gets more specific and told what to grow
The growth stage
grows inward and outward
growth start and stop at specific regions on the geomap
detail genes start which differentiate traits even more
Deep homology
many genes shared across all eukaryotes must have evolved in the first eukaryote
most important genes evolved very early in eukaryotes, share the exact same gene regions regulating development (homeobox genes)
Homeobox genes
are how we can share much of our genomes with other eukaryotes but look very different
even for eye, share many of the same genes for building
What really makes a phenotype
many of the phenotypes we once thought were linked to a single gene
more a product of homeobox or detail genes growth turning on and off
new phenotypes arise when mutations occur that modify gene regulation (when on and off and where on the geomap), not a mutation in a single gene
zebras have the same detail gene but different points they turn on and off or where on the geomap
Examples: Melanism, mimicry,
if a few genes control wings or melanism, higher chance these will be mutated over time
if melanism is turned on for entire organism instead of specific region of geomap, change in phenotype from simple mutation
This is how they have similar wing patterns, and if mimicry is advantageous, natural selection will preserve it in both species
Redundant genes
key discovery in EVO DEVO: when a gene is not longer needed for its original purpose, can easily be repurposed into something functionally similar by evolution
ex: gills and wings
very similar in structure, very few changes needed to repurpose gills to wings
(homeobox genes code for gills, modified)
Increasing Complexity in genes
increasing trait complexity (more homeobox genes) in newer species, despite full genome not always getting bigger
because of homeobox duplication
when you have extra developmental genes, thy can be repurposed for other functions like limbs or organs