Everything Else Flashcards

MCP OA in a young person = think HEMOCHROMATOSIS
genotype assoc w/ RA
HLA-DRB1 - confers 4x risk for RA (Class II HLA w/ CD4
citrullinated peptides bind –> QKRAA
HLA Class II alleles (DR, DP, DQ) are most strongly assoc w/ what disease?
narcolepsy-cataplexy
Wolff’s Law
force applied to bone surface –> bone deposition
force removed –> bone removed
longitudinal bone grows by….
endochondral ossification


lamellar bone grows by….
appositional bone growth


osteon and haversian system
woven bone in adult
pathological!!
mortality one yr after hip fracture
35%
fill in table about ages, features, and subgroups of JIA

pathogenesis of synovitis (JIA)
- villous hyperplasia of synovium
- hypervascularity
- infiltration of lymph + macrophages
sx of JIA
mostly synovitis >>>>>
- joint contracture
- +/- erosions,
- +/- deformity and functional limitations
what kind of JIA has a high risk of uveitis?
oligoarticular, ANA+
screen in kids <7 w/ +ANA!!!
chilblain’s perniosis
like the venous phase of raynauds.
- venodilation –> pooling of blood in toes and non-specifc inflammation