Everything Else Flashcards

MCP OA in a young person = think HEMOCHROMATOSIS
genotype assoc w/ RA
HLA-DRB1 - confers 4x risk for RA (Class II HLA w/ CD4
citrullinated peptides bind –> QKRAA
HLA Class II alleles (DR, DP, DQ) are most strongly assoc w/ what disease?
narcolepsy-cataplexy
Wolff’s Law
force applied to bone surface –> bone deposition
force removed –> bone removed
longitudinal bone grows by….
endochondral ossification


lamellar bone grows by….
appositional bone growth


osteon and haversian system
woven bone in adult
pathological!!
mortality one yr after hip fracture
35%
fill in table about ages, features, and subgroups of JIA

pathogenesis of synovitis (JIA)
- villous hyperplasia of synovium
- hypervascularity
- infiltration of lymph + macrophages
sx of JIA
mostly synovitis >>>>>
- joint contracture
- +/- erosions,
- +/- deformity and functional limitations
what kind of JIA has a high risk of uveitis?
oligoarticular, ANA+
screen in kids <7 w/ +ANA!!!
chilblain’s perniosis
like the venous phase of raynauds.
- venodilation –> pooling of blood in toes and non-specifc inflammation

acrocyanosis - normal redistrib of blood flow in a newborn
anti-RNP +
assoc w/ mixed connective tissue disease
mixed connective tissue disease
- inflammatory arthritis
- raynaud’s
- morphea
- DM or amyopathic DM
2 vasculitides in children
- HSP
- Kawasaki’s
dx criteria for Kawasaki


strawberry tongue in Kawasaki
tx for Kawasaki
aspirin and IVIg –> reduces aneurysms to 5%
do echo @ baseline, 3, 7 weeks
continue aspirin for 3wks after last normal echo

calcinosis in juvenile dermatomyositis
composition of type I collagen
trimer of 2 alpha-1 and 1 alpha-2 monomers
pleiotrophy
many effects of a single mutation (in one person’s body)
genetic heterogeneity
different mutations can cause the same disease
variable expression
disease effects of an identical mutations may differ in different people
mutations assoc w/ OI
COL1A1 or COL1A2
osteomyelitis - histology findings
lots of neutrophils
what cancers metastasize to bone
Breast, lung, thyroid, kidney, prostate (BLT w/ kosher pickle)
disc herniation
- young pt
- normal disc height
- radicular pain
usually through posterolateral corner of annulus
disc degeneration
- middle aged subject
- activity related mechanical back pain
- referred pain to leg
- instability catch
spinal stenosis
- elderly pt
- neurogenic claudication: standing –> leg pain w/ chopping cart sign
- osteophytes –> disk narrowing
degenerative spondylolisthesis
- middle aged or elderly, esp women
- mech back pain + radiculopathy
- L4-L5
what do fibroblast growth factors do in bone healing?
enhance callus formation: fibrous, cartilage, immature bone
what do cytokines do in bone healing?
stimulate bone resorption (esp IL-1)