Everything Else Flashcards

1
Q
A

MCP OA in a young person = think HEMOCHROMATOSIS

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2
Q

genotype assoc w/ RA

A

HLA-DRB1 - confers 4x risk for RA (Class II HLA w/ CD4

citrullinated peptides bind –> QKRAA

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3
Q

HLA Class II alleles (DR, DP, DQ) are most strongly assoc w/ what disease?

A

narcolepsy-cataplexy

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4
Q

Wolff’s Law

A

force applied to bone surface –> bone deposition

force removed –> bone removed

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5
Q

longitudinal bone grows by….

A

endochondral ossification

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6
Q
A
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7
Q

lamellar bone grows by….

A

appositional bone growth

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8
Q
A

osteon and haversian system

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9
Q

woven bone in adult

A

pathological!!

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10
Q

mortality one yr after hip fracture

A

35%

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11
Q

fill in table about ages, features, and subgroups of JIA

A
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12
Q

pathogenesis of synovitis (JIA)

A
  • villous hyperplasia of synovium
  • hypervascularity
  • infiltration of lymph + macrophages
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13
Q

sx of JIA

A

mostly synovitis >>>>>

  • joint contracture
  • +/- erosions,
  • +/- deformity and functional limitations
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14
Q

what kind of JIA has a high risk of uveitis?

A

oligoarticular, ANA+

screen in kids <7 w/ +ANA!!!

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15
Q

chilblain’s perniosis

A

like the venous phase of raynauds.

  • venodilation –> pooling of blood in toes and non-specifc inflammation
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16
Q
A

acrocyanosis - normal redistrib of blood flow in a newborn

17
Q

anti-RNP +

A

assoc w/ mixed connective tissue disease

18
Q

mixed connective tissue disease

A
  • inflammatory arthritis
  • raynaud’s
  • morphea
  • DM or amyopathic DM
19
Q

2 vasculitides in children

A
  • HSP
  • Kawasaki’s
20
Q

dx criteria for Kawasaki

21
Q
A

strawberry tongue in Kawasaki

22
Q

tx for Kawasaki

A

aspirin and IVIg –> reduces aneurysms to 5%

do echo @ baseline, 3, 7 weeks

continue aspirin for 3wks after last normal echo

23
Q
A

calcinosis in juvenile dermatomyositis

24
Q

composition of type I collagen

A

trimer of 2 alpha-1 and 1 alpha-2 monomers

25
Q

pleiotrophy

A

many effects of a single mutation (in one person’s body)

26
Q

genetic heterogeneity

A

different mutations can cause the same disease

27
Q

variable expression

A

disease effects of an identical mutations may differ in different people

28
Q

mutations assoc w/ OI

A

COL1A1 or COL1A2

29
Q

osteomyelitis - histology findings

A

lots of neutrophils

30
Q

what cancers metastasize to bone

A

Breast, lung, thyroid, kidney, prostate (BLT w/ kosher pickle)

32
Q

disc herniation

A
  • young pt
  • normal disc height
  • radicular pain

usually through posterolateral corner of annulus

33
Q

disc degeneration

A
  • middle aged subject
  • activity related mechanical back pain
  • referred pain to leg
  • instability catch
34
Q

spinal stenosis

A
  • elderly pt
  • neurogenic claudication: standing –> leg pain w/ chopping cart sign
  • osteophytes –> disk narrowing
35
Q

degenerative spondylolisthesis

A
  • middle aged or elderly, esp women
  • mech back pain + radiculopathy
  • L4-L5
36
Q

what do fibroblast growth factors do in bone healing?

A

enhance callus formation: fibrous, cartilage, immature bone

37
Q

what do cytokines do in bone healing?

A

stimulate bone resorption (esp IL-1)