Eukaryotic Microbes (fungus)

Question 1

Aspergillus

Answer 1

-Common airborne allergen

Forms of Disease:

• ABPA
• Chronic pulmonary aspergillosis

*azole resistant

Question 2

Aspergillosis (genus)

Answer 2

• Life threatening to ummunocompromised
• infection via inhalation of spores (ball of fungus inside host)

Asymptomatic (early stages)

• ->dry cough
• ->coughing blood
• ->shortness of breath

Question 3

Candida

Answer 3

• Resident flora (microorganisms that occupy a particular body site)
• ->skin, mucous membrane
• ->commensal organism

Question 4

Candidiasis

Answer 4

Opportunistic infection- affects individuals w/ weakened immune system

Sites of infection:

• Oral “thrush”
• Vaginal “yeast infection”
• Invasive (systemic) - candidemia
• Babies “diaper rash”

Question 5

Phylum - Zygomycota

Answer 5

-coenocytic hyphae (one long cell - not divided into compartment)

• Bread molds
• –>starch & sugar digestion
• —–>cannot digest cellulose

Zygomycota infections of RARE

• -mucromycosis (molds live thru. environment)
• -oportunistic pathogen (affects weak immune systems)

Question 6

Phylum Basidomycota

Answer 6

• shrooms
• septate hyphae (walls between cells)

Pathogens:
-Cryptococcus neoformans

TOXIC

Question 7

Histoplasmosis

Answer 7

-DIMORPHIC FUNGUS (molds and yeast)

1. histoplasmosis capsulatum - MOLD
   - –>Derial hyphae
2. Hyphae produce macroconidia & microconidia; spores are aerosolized and dispersed
3. Microconidia - inhaled to lungs by susceptible host
4. Warm temp in host = budding yeast
5. Yeast is phagocytized (living cells ingest other cells or particles) by immune cells and transported to lymph
6. lymph nodes –> travel in blood to other parts of body