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Hematology > Ettinger > Flashcards

Ettinger Flashcards

1
Q

Which Th mediates immune mediated disease?

A

Th2

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2
Q

What factors are involve in:

  • intrinsic
  • extrinsic
  • common
A
  • intrinsic: XII, IX, VIII
  • extrinsic: tissue factor, VII
  • common: X, V , prothrombin (II), fibrinogen(I), XIII
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3
Q

What test will be prolonged first in rodenticide intoxication?

A

PT (within 36-72 hours)

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4
Q

Scott syndrome:

  • results in ____
  • affects ____ breed
A

Defect procoagulant activity on platelet surface

German Shepherd

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5
Q

Hemophilia

  • which factor
  • results in
  • PT/PTT prolongation
A

A= VIII B = IX
Inhibit formation of tenase complex
PTT elevation

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6
Q

Which cell provide iron necessary for hemoglobin production?

A

Macrophages

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7
Q

How long does it takes for reticulocytes release?

A

2-5 days

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8
Q

Which type of IMHA carries the worst prognosis?

A

Intravascular

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9
Q

Which genetic erythrocyte enzyme deficiency causes impaired erythrocyte energy metabolism?

A
  • Pyruvate kinase (iron overload)
  • Phosphofructokinase defiency
  • Hereditary spectrum deficiency
  • Genetic membrane disorders
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10
Q

What can result in EPO deficiency

A
  • Kidney (peritubular interstitial cells of inner renal vortex and outer medulla)
  • PTH
  • Hypoalbuminemia
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11
Q

Why does inflammation results in decreased erythropoiesis?

A

IL-6 increases production of hepcidin which internalize ferroporrietin, prevent release of iron from macrophages and hepatocytes + blocks intestinal iron absorption

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12
Q

Which does hypocobalaminemia results in abnormal erythropoiesis ?

A

Impaired DNA synthesis within erythroblast

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13
Q

What mutation is associated with polycythemia Vera?

A

JAK2

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14
Q

Which cancer can result in secondary polycythemia?

A

Nasal fibrosarcoma, shwannoma , cecal leiomyosarcoma, renal carcinoma/lymphoma/fibrosarcoma

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15
Q

What are the signs of hyperviscosity?

A

CNS
Hemorrhage
Pu/PD
Vomiting/diarrhea

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16
Q

Antibodies in ITP are directed against what ?

A

IgG against GPIIb/IIIa

17
Q

Chediak-Higashi

Breed and describe

A

Persian
Bleu smoke coat
Results in neutrophils and platelet function defects

18
Q

Pelger-Huët

Breed and describe

A

Australian Shepherd

Hyposegmented nuclei

19
Q

Leucocytes adhésion factors

Breed

A

Irish setter

20
Q

Trapped neutrophils syndrome

Breed

A

Border collies

21
Q

Progressive myelofibrodis of the bone marrow along with changes in the liver

A

Pyruvate kinase deficiency

22
Q

X-linked combined immunodeficiency
Describe
Which cell are affected
Breed

A

Mutation in the gene encoding for IL-2
CD4 ans CD8 thymocytes
Welsh corgi and basset

23
Q

Autosomal severe combined deficiency

  • describe
  • results in
  • breed
A

Mutation in gene of DNA dependent protein kinase
- lymphopenia, hypoglobulinemia
Jack Russel terrier

24
Q

Which mutation results in cyclic hématopoïèsis of the gray collies

A

AP3B1

25
Q

Lymphocyte function déficit

  • breed
  • results in ____ infection
A

CKC and dachshund

Pneumocystis catimini

26
Q

Which Protozoa can be find in macrophages?

A

Neospora, toxoplasma, cytauxzoon, leishmaniasis and hepatozoon

27
Q

Breed that gets leishmaniasis in USA

A

Americans foxhounds

28
Q

Which breed is predisposed to iatrogenic reactive polyarthrites

A

Doberman pinscher

29
Q

Which cancer can result in IMPA?

A

Carcinoma (tonsillar, mammary and renal)
Seminoma
Sertoli cell tumor
Leiomyoma

30
Q

Nonerosive primary IMPA

  • breed
  • which articulation
A 
Shar pei (overexpressiom of hyalurinic acid, give colchicine) and Akita
Carpus and tarsus
31
Q

Erosive IMPA

  • breed
  • cat particularity
A

Greyhound

Periosteal proliferative arthritis

32
Q

Pemphigus foliaceus have antibodies against what and which breed

A

Desmosomal-1

Akita and chow chow

33
Q

Mucous membrane penphigoid

  • antibodies
  • breeds
A

Collagen XVII

German Shepherd

34
Q

Epidermolysis bullosa acquisita

  • antibodies
  • breed
A

Collagen VII

Male Great Dane

35
Q

Vésicular cutaneous lupus erythematosus

- breed

A

Female Shetland sheepdogs

36
Q

Exfoliative cutaneous lupus erythematosus

  • breed
  • prognosis
A

Female German short haired pointer

37
Q

Mucocutaneous lupus erythematosus?

A

Female German Shepherd

38
Q

SLE is inherited in which breed?

A

Nova Scotia

39
Q

Systems that can be affected by SLE?

A 
Nonerosive polyarthrite 
Rénal
Dermatologie 
Bone marrow 
Myosotis
Cardiac
CNS

Hematology (3 decks)

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