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Life Cycles- Unit 1- LAH > Estrogen/Progesterone Drugs > Flashcards

Estrogen/Progesterone Drugs Flashcards

1
Q

SERMs:

prevent breast cancer?

A

Tamoxifen AND

Raloxifene

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2
Q

SERMs:

increased risk of endometrial cancer?

A

Tamoxifen

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3
Q

SERMs:

inhibit osteoClasts?

A

Raloxifene

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4
Q

SERMs:

cause vasomotor symptoms?

A

Tamoxifen AND

Raloxifene

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5
Q

What is tamoxifen used for?

A

tx of breast cancer

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6
Q

For women with an intact uterus, risk of endometrial cancer is reduced if HRT is given with _____.

A

progestin

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7
Q 
A 70-year-old woman is being treated with raloxifene for osteoporosis. Which of the following is a concern with this therapy?
A. Breast cancer
B. Endometrial cancer
C. Hot flashes
D. Venous thrombosis
E. Hypercholesterolemia
A

Raloxifene =
C. Hot flashes
D. Venous thrombosis

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8
Q

A 53 year-old woman has severe vasomotor symptoms (hot flashes) associated with menopause. She has no pertinent past medical or surgical history. Which of the following would be most appropriate for her symptoms?
A. Conjugated estrogens vaginal cream
B. Estradiol transdermal patch
C. Oral estradiol and medroxyprogesterone
D. Injectable medroxyprogesterone acetate
E. Oral tamoxifen

A

C. Oral estradiol and medroxyprogesterone

***she needs systemic E with a progesterone b/c of her intact uterus.

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9
Q

A young woman complains of abdominal pain at the time of menstruation. Careful evaluation indicates the presence of significant endometrial deposits on the pelvic peritoneum. Which of the following would be the most appropriate medical therapy for this patient?
A. Bicalutamide orally
B. Medroxyprogesterone acetate by intramuscular injection
C. Norgestrel as an IUD
D. Oxandrolone by intramuscular injection
E. Raloxifene orally

A

B. Medroxyprogesterone acetate by intramuscular injection

*** need a high injectable dose- this is Depo

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10
Q

What are the positive long-term SEs associated with COCs (combined oral contraceptives)?

A

reduced endometrial and ovarian CA

decreased colon CA

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11
Q

What are the negative long-term SEs associated with COCs (combined oral contraceptives)?

A

increased risk of breast CA

increased risk of cervical cancer IF >5yr use AND HPV+

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12
Q 
A 26-year-old female is using injectable medroxyprogesterone acetate as a method of contraception. An adverse effect of concern with long-term use of this therapy is:
A. Hyperkalemia
B. Male pattern baldness
C. Osteoporosis
D. Weight loss
E. Weight gain
A

C. Osteoporosis (bc decreased ovarian function and therefore decreased E)
E. Weight gain

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13
Q

What is an adverse SE of drosperinone use?

A

hyperkalemia

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14
Q 
Which of the following would be the most appropriate oral contraceptive for a patient with moderate acne?
A. Ethinyl estradiol - levonorgestrel
B. Ethinyl estradiol - norethindrone
C. Ethinyl estradiol - desogestrel
D. Medroxyprogesterone
E. Ulipristal
A

C. Ethinyl estradiol - desogestrel

*** 3rd generation = decreased androgenic activity

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15
Q

Name a first generation COC and its unique SEs.

A

Norethindrone; none

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16
Q

Name a second generation COC and its unique SEs.

A

Levonorgestrel; decreased VTE risk but increased androgenic actions

17
Q

Name a third generation COC and its unique SEs.

A

Desogestrel-norethynodrel-norgestimate; lower androgenic activity, higher VTE risk

18
Q

Name a 4th generation COC and its unique SEs.

A

Drospirenone

antimineralocorticoid and antiandrogenic –> increased VTE risk

19
Q

Name a drug that induces or enhances estrogen metabolism, leading to a reduction in contraceptive effect.

A

Rifampin

20
Q

What is Levonorgestrel?

A

Plan B

21
Q

What is Ulipristal?

A

Ella (new plan B)

22
Q

Name 2 androgen receptor antagonists.

A

Spironolactone

Flutamide

23
Q

Name two 5-alpha-reductase inhibitors.

A

Finasteride

Dutasteride

24
Q

Name a progesterone receptor antagonist.

A

Mifepristone

25
Q

Name 2 aromatase inhibitors.

A

Exemestane/Formestane

Anastrozole/Letrozole

26
Q 
A 50-year-old woman with a positive mammogram undergoes lumpectomy and a small carcinoma is removed. Biochemical analysis of the cancer reveals the presence of estrogen and progesterone receptors. After this procedure she will probably receive which of the following drugs?
A. Bicalutamide
B. Clomiphene
C. Leuprolide 
D. Mifepristone
E. Tamoxifen
F. Testosterone enanthate
A

E. Tamoxifen

27
Q

Name an estrogen receptor partial agonists/antagonist.

A

Clomiphene

28
Q

What is Clomiphene used for?

A

to stimulate ovulation

29
Q

What is Mifepristone used for?

A

medicinal abortions

30
Q

What does aromatase do?

A

converts testosterone to estrogen

31
Q

How do SERMs work?

A

they are E nuclear receptor antagonists –> cause dimerization of the receptors –> recruit co-repressors

Life Cycles- Unit 1- LAH (2 decks)

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