Androgen Pharm

Question 1

Testosterone + aromatase = ?

Answer 1

estradiol

Question 2

Testosterone + 5-alpha-reductase = ?

Answer 2

DHT

Question 3

Name two 5-alpha-reductase inhibitors.

Answer 3

Finasteride and Dutasteride

Question 4

What is Finasteride used for?

Answer 4

prostate CA, hair loss

Question 5

What is Dutasteride used for?

Answer 5

prostate CA

Question 6

Symptoms related specifically to androgen deficiency in aging males include:
A. Fatigue
B. Increased fat
C. Low libido
D. Depression
E. Low bone mineral density

Answer 6

C. Low libido
E. Low bone mineral density

*** others were nonspecific.

Question 7

Which of the following natural or synthetic steroids has both anabolic activity and androgenic activity in humans?
A. Testosterone
B. Methyltestosterone
C. Oxandrolone
D. Nandrolone
E. Stanozolol
F. All of the above

Answer 7

F. All of the above

*** ALL steroids are both anabolic and androgenic.

Question 8

Which route of testosterone administration maintains the most stable plasma T levels throughout the dosing interval?

Answer 8

transdermal gel

Question 9

Adverse effects associated with androgen use can include all of the following EXCEPT:
A. Anemia
B. Decreased spermatogenesis
C. Testicular enlargement
D. Prostate enlargement
E. Gynecomastia
F. Hepatotoxicity

Answer 9

A. Anemia

C. Testicular enlargement

Question 10

Name 3 GnRH agonists.

Answer 10

Leuprolide
Goserelin
Nafarelin

Question 11

Name 2 GnRH antagonists.

Answer 11

Cetrorelix

Ganirelix

Question 12

Name two 5-alpha-reductase inhibitors.

Answer 12

Finasteride

Dutasteride

Question 13

Name two androgen receptor antagonists.

Answer 13

Flutamide

Spironolactone

Question 14

Finasteride has efficacy in the prevention of male-pattern baldness by virtue of its ability to:
A. Competitively antagonize androgen receptors
B. Decrease the release of gonadotropins
C. Increase the serum concentration of sex hormone-binding globulin (SHBG)
D. Inhibit the synthesis of testosterone
E. Reduce the production of dihydrotestosterone

Answer 14

E. Reduce the production of dihydrotestosterone

*** Finasteride = 5-alpha-reductase inhibitor

Question 15

A 60-year-old man is found to have a prostate lump and an elevated prostate-specific antigen. MRI suggests several enlarged lymph nodes in the lower abdomen, and an x-ray reveals 2 radiolucent lesions in the bony pelvis. This patient is likely to treated with which of the following drugs?
A. Letrozole
B. Desogestrel
C. Flutamide
D. Methyltestosterone
E. Oxandrolone
F. Leuprolide

Answer 15

C. Flutamide
F. Leuprolide

*** Flutamide = androgen receptor antagonist
Leuprolide = GnRH agonist

Question 16

Benign prostatic hypertrophy (BPH) can be characterized by frequent urinary urgency, diminished urinary stream, urinary retention, and prostate-specific antigen (PSA) within normal limits for age. Which of the following best describes how an α1-adrenergic antagonist improves urinary flow?
A. Decreases urine production
B. Decreases the resistance of the urethral sphincter
C. Promotes relaxation of the detrusor muscle
D. Reduces formation of urethral nitric oxide
E. Reduces formation of dihydrotestosterone

Answer 16

B. Decreases the resistance of the urethral sphincter

Question 17

What drug classes are used to treat BPH symptoms?

Answer 17

Alpha-1 blockers

5-alpha-reductase inhibitors (finasteride, dutasteride)